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- W4384664164 abstract "We present a new thermodynamic model to investigate the relative effects of excluded volume and soft interaction contributions in determining whether a cosolute will either destabilize or stabilize a protein in solution. This model is unique in considering an atomistically detailed model of the protein and accounting for the preferential accumulation/exclusion of the osmolyte molecules from the protein surface. Importantly, we use molecular dynamics simulations and experiments to validate the model. The experimental approach presents a unique means of decoupling excluded volume and soft interaction contributions using a linear polymeric series of cosolutes with different numbers of glucose subunits, from 1 (glucose) to 8 (maltooctaose), as well as an 8-mer of glucose units in the closed form (γ-CD). By studying the stabilizing effect of cosolutes along this polymeric series using lysozyme as a model protein, we validate the thermodynamic model and show that sugars stabilize proteins according to an excluded volume mechanism." @default.
- W4384664164 created "2023-07-20" @default.
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- W4384664164 date "2023-07-19" @default.
- W4384664164 modified "2023-10-18" @default.
- W4384664164 title "Thermodynamic Modeling and Experimental Data Reveal That Sugars Stabilize Proteins According to an Excluded Volume Mechanism" @default.
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- W4384664164 doi "https://doi.org/10.1021/jacs.3c04293" @default.
- W4384664164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37466340" @default.
- W4384664164 hasPublicationYear "2023" @default.
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