FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384665972> ?p ?o ?g. }

• W4384665972 abstract "Introduction: Chirality is a crucial mechanical cue within the extracellular matrix during tissue repair and regeneration. Despite its key roles in cell behavior and regeneration efficacy, our understanding of chirality-biased protein profile in vivo remains unclear. Methods: In this study, we characterized the proteomic profile of proteins extracted from bone defect areas implanted with left-handed and right-handed scaffold matrices during the early healing stage. We identified differentially-expressed proteins between the two groups and detected heterogenic characteristic signatures on day 3 and day 7 time points. Results: Proteomic analysis showed that left-handed chirality could upregulate cell adhesion-related and GTPase-related proteins on day 3 and day 7. Besides, interaction analysis and in vitro verification results indicated that the left-handed chiral scaffold material activated Rho GTPase and Akt1, ultimately leading to M2 polarization of macrophages. Discussion: In summary, our study thus improved understanding of the regenerative processes facilitated by chiral materials by characterizing the protein atlas in the context of bone defect repair and exploring the underlying molecular mechanisms of chirality-mediated polarization differences in macrophages." @default.
• W4384665972 created "2023-07-20" @default.
• W4384665972 creator A5000176555 @default.
• W4384665972 creator A5006772443 @default.
• W4384665972 creator A5020935596 @default.
• W4384665972 creator A5043016937 @default.
• W4384665972 creator A5066969731 @default.
• W4384665972 creator A5076822031 @default.
• W4384665972 creator A5083899273 @default.
• W4384665972 date "2023-07-18" @default.
• W4384665972 modified "2023-09-27" @default.
• W4384665972 title "Chirality-biased protein expression profile during early stages of bone regeneration" @default.
• W4384665972 cites W1891318431 @default.
• W4384665972 cites W1981056356 @default.
• W4384665972 cites W2024616045 @default.
• W4384665972 cites W2030574023 @default.
• W4384665972 cites W2069231540 @default.
• W4384665972 cites W2117138208 @default.
• W4384665972 cites W2133465414 @default.
• W4384665972 cites W2136110105 @default.
• W4384665972 cites W2163174986 @default.
• W4384665972 cites W2167158605 @default.
• W4384665972 cites W2210729715 @default.
• W4384665972 cites W2580365938 @default.
• W4384665972 cites W2582393724 @default.
• W4384665972 cites W2752468329 @default.
• W4384665972 cites W2773857302 @default.
• W4384665972 cites W2885189035 @default.
• W4384665972 cites W2892039614 @default.
• W4384665972 cites W2901287717 @default.
• W4384665972 cites W2921931280 @default.
• W4384665972 cites W2947325783 @default.
• W4384665972 cites W2947816645 @default.
• W4384665972 cites W2969551943 @default.
• W4384665972 cites W3098521947 @default.
• W4384665972 cites W3111964943 @default.
• W4384665972 cites W3135850908 @default.
• W4384665972 cites W3141681677 @default.
• W4384665972 cites W3141826802 @default.
• W4384665972 cites W3194753014 @default.
• W4384665972 cites W3203990955 @default.
• W4384665972 cites W3206512271 @default.
• W4384665972 cites W4220911943 @default.
• W4384665972 cites W4224657282 @default.
• W4384665972 cites W4226285874 @default.
• W4384665972 cites W4280513768 @default.
• W4384665972 cites W4282925283 @default.
• W4384665972 cites W4293106120 @default.
• W4384665972 cites W4318323575 @default.
• W4384665972 cites W4321018211 @default.
• W4384665972 cites W4321331271 @default.
• W4384665972 cites W4378983252 @default.
• W4384665972 doi "https://doi.org/10.3389/fbioe.2023.1217919" @default.
• W4384665972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37533694" @default.
• W4384665972 hasPublicationYear "2023" @default.
• W4384665972 type Work @default.
• W4384665972 citedByCount "0" @default.
• W4384665972 crossrefType "journal-article" @default.
• W4384665972 hasAuthorship W4384665972A5000176555 @default.
• W4384665972 hasAuthorship W4384665972A5006772443 @default.
• W4384665972 hasAuthorship W4384665972A5020935596 @default.
• W4384665972 hasAuthorship W4384665972A5043016937 @default.
• W4384665972 hasAuthorship W4384665972A5066969731 @default.
• W4384665972 hasAuthorship W4384665972A5076822031 @default.
• W4384665972 hasAuthorship W4384665972A5083899273 @default.
• W4384665972 hasBestOaLocation W43846659721 @default.
• W4384665972 hasConcept C121332964 @default.
• W4384665972 hasConcept C124668440 @default.
• W4384665972 hasConcept C12554922 @default.
• W4384665972 hasConcept C151730666 @default.
• W4384665972 hasConcept C171056886 @default.
• W4384665972 hasConcept C185592680 @default.
• W4384665972 hasConcept C189165786 @default.
• W4384665972 hasConcept C20621625 @default.
• W4384665972 hasConcept C2779343474 @default.
• W4384665972 hasConcept C52703039 @default.
• W4384665972 hasConcept C62520636 @default.
• W4384665972 hasConcept C7602139 @default.
• W4384665972 hasConcept C86803240 @default.
• W4384665972 hasConcept C95444343 @default.
• W4384665972 hasConceptScore W4384665972C121332964 @default.
• W4384665972 hasConceptScore W4384665972C124668440 @default.
• W4384665972 hasConceptScore W4384665972C12554922 @default.
• W4384665972 hasConceptScore W4384665972C151730666 @default.
• W4384665972 hasConceptScore W4384665972C171056886 @default.
• W4384665972 hasConceptScore W4384665972C185592680 @default.
• W4384665972 hasConceptScore W4384665972C189165786 @default.
• W4384665972 hasConceptScore W4384665972C20621625 @default.
• W4384665972 hasConceptScore W4384665972C2779343474 @default.
• W4384665972 hasConceptScore W4384665972C52703039 @default.
• W4384665972 hasConceptScore W4384665972C62520636 @default.
• W4384665972 hasConceptScore W4384665972C7602139 @default.
• W4384665972 hasConceptScore W4384665972C86803240 @default.
• W4384665972 hasConceptScore W4384665972C95444343 @default.
• W4384665972 hasFunder F4320321001 @default.
• W4384665972 hasFunder F4320321543 @default.
• W4384665972 hasFunder F4320325902 @default.
• W4384665972 hasFunder F4320335777 @default.
• W4384665972 hasLocation W43846659721 @default.
• W4384665972 hasLocation W43846659722 @default.

• next