FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384666111> ?p ?o ?g. }

• W4384666111 abstract "Introduction Although, codeine has been demonstrated to lower sperm quality; the effects of maternal and prepubertal codeine exposure on male offspring is yet to be reported. In addition, the effect of arginine on codeine-induced decline in sperm quality has not been explored. This study investigated the impact of maternal and prepubertal codeine exposure on spermatogenesis and sperm quality in F1 male Wistar rats to study the effect that codeine may have during recreational use in humans. Also, the effect of arginine supplementation on codeine-induced alteration in spermatogenesis and sperm quality was evaluated. Methods Female rats were treated with either 0.5 ml distilled water or codeine orally for eight weeks, and then mated with male rats (female:male, 2:1). The F1 male offsprings of both cohorts were weaned at 3 weeks old and administered distilled water, codeine, arginine, or codeine with arginine orally for eight weeks. Results Prepubertal codeine exposure in rats whose dams (female parents) were exposed to codeine delayed puberty and reduced the weight at puberty. Prepubertal codeine exposure exacerbated maternal codeine exposure-induced reduced total and daily spermatid production, sperm count, sperm motility, and normal sperm form, as well as impaired sperm plasma membrane integrity and increased not intact acrosome and damaged sperm DNA integrity. These perturbations were accompanied by a decrease in mRNA levels encoding spermatogenic genes, testicular testosterone and androgen receptor (AR) concentrations, and upregulation of sperm 8-hydroxydeoxyguanosine (8OHdG). Prepubertal arginine supplementation mitigated codeine-induced alterations. Discussion This study provides novel experimental evidence that maternal and prepubertal codeine exposure reprogramed spermatogenesis and sperm quality of male FI generation by decreasing mRNA levels encoding spermatogenic genes and AR via oxidative stress-mediated signaling, which was abrogated by prepubertal arginine supplementation." @default.
• W4384666111 created "2023-07-20" @default.
• W4384666111 creator A5005025493 @default.
• W4384666111 creator A5052711760 @default.
• W4384666111 creator A5066267821 @default.
• W4384666111 date "2023-07-17" @default.
• W4384666111 modified "2023-09-25" @default.
• W4384666111 title "L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes" @default.
• W4384666111 cites W1992888580 @default.
• W4384666111 cites W1995239116 @default.
• W4384666111 cites W1996944297 @default.
• W4384666111 cites W1997352429 @default.
• W4384666111 cites W2004469122 @default.
• W4384666111 cites W2013234055 @default.
• W4384666111 cites W2032824621 @default.
• W4384666111 cites W2049218865 @default.
• W4384666111 cites W2054227830 @default.
• W4384666111 cites W2054949240 @default.
• W4384666111 cites W2058262210 @default.
• W4384666111 cites W2079203307 @default.
• W4384666111 cites W2120161083 @default.
• W4384666111 cites W2126695143 @default.
• W4384666111 cites W2128478608 @default.
• W4384666111 cites W2131093877 @default.
• W4384666111 cites W2149350777 @default.
• W4384666111 cites W2312756034 @default.
• W4384666111 cites W2341650343 @default.
• W4384666111 cites W2778394939 @default.
• W4384666111 cites W2789917838 @default.
• W4384666111 cites W2944047992 @default.
• W4384666111 cites W2981096978 @default.
• W4384666111 cites W2997819581 @default.
• W4384666111 cites W3010338511 @default.
• W4384666111 cites W3011420006 @default.
• W4384666111 cites W3015904273 @default.
• W4384666111 cites W3035507611 @default.
• W4384666111 cites W3097621317 @default.
• W4384666111 cites W3101497214 @default.
• W4384666111 cites W3106989224 @default.
• W4384666111 cites W3115890485 @default.
• W4384666111 cites W3119186284 @default.
• W4384666111 cites W3135032154 @default.
• W4384666111 cites W3167748821 @default.
• W4384666111 cites W3179416278 @default.
• W4384666111 cites W3191526477 @default.
• W4384666111 cites W3195823141 @default.
• W4384666111 cites W3200910429 @default.
• W4384666111 cites W4211005481 @default.
• W4384666111 cites W4211108506 @default.
• W4384666111 cites W4213457704 @default.
• W4384666111 cites W4214850752 @default.
• W4384666111 cites W4248054385 @default.
• W4384666111 cites W4295422381 @default.
• W4384666111 cites W4299607837 @default.
• W4384666111 doi "https://doi.org/10.3389/fendo.2023.1180085" @default.
• W4384666111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37529606" @default.
• W4384666111 hasPublicationYear "2023" @default.
• W4384666111 type Work @default.
• W4384666111 citedByCount "0" @default.
• W4384666111 crossrefType "journal-article" @default.
• W4384666111 hasAuthorship W4384666111A5005025493 @default.
• W4384666111 hasAuthorship W4384666111A5052711760 @default.
• W4384666111 hasAuthorship W4384666111A5066267821 @default.
• W4384666111 hasBestOaLocation W43846661111 @default.
• W4384666111 hasConcept C123765429 @default.
• W4384666111 hasConcept C126322002 @default.
• W4384666111 hasConcept C134018914 @default.
• W4384666111 hasConcept C16685009 @default.
• W4384666111 hasConcept C2777389121 @default.
• W4384666111 hasConcept C2777468819 @default.
• W4384666111 hasConcept C2777632594 @default.
• W4384666111 hasConcept C2777866328 @default.
• W4384666111 hasConcept C2781087480 @default.
• W4384666111 hasConcept C515207424 @default.
• W4384666111 hasConcept C54355233 @default.
• W4384666111 hasConcept C71924100 @default.
• W4384666111 hasConcept C86803240 @default.
• W4384666111 hasConceptScore W4384666111C123765429 @default.
• W4384666111 hasConceptScore W4384666111C126322002 @default.
• W4384666111 hasConceptScore W4384666111C134018914 @default.
• W4384666111 hasConceptScore W4384666111C16685009 @default.
• W4384666111 hasConceptScore W4384666111C2777389121 @default.
• W4384666111 hasConceptScore W4384666111C2777468819 @default.
• W4384666111 hasConceptScore W4384666111C2777632594 @default.
• W4384666111 hasConceptScore W4384666111C2777866328 @default.
• W4384666111 hasConceptScore W4384666111C2781087480 @default.
• W4384666111 hasConceptScore W4384666111C515207424 @default.
• W4384666111 hasConceptScore W4384666111C54355233 @default.
• W4384666111 hasConceptScore W4384666111C71924100 @default.
• W4384666111 hasConceptScore W4384666111C86803240 @default.
• W4384666111 hasLocation W43846661111 @default.
• W4384666111 hasLocation W43846661112 @default.
• W4384666111 hasLocation W43846661113 @default.
• W4384666111 hasOpenAccess W4384666111 @default.
• W4384666111 hasPrimaryLocation W43846661111 @default.
• W4384666111 hasRelatedWork W2042353100 @default.
• W4384666111 hasRelatedWork W2258951291 @default.
• W4384666111 hasRelatedWork W2370474286 @default.
• W4384666111 hasRelatedWork W2411410820 @default.
• W4384666111 hasRelatedWork W3017809499 @default.

• next