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- W4384666261 abstract "Impaired myocardial Ca 2+ cycling is a critical contributor to the development of heart failure (HF), causing changes in the contractile function and structure remodeling of the heart. Within cardiomyocytes, the regulation of sarcoplasmic reticulum (SR) Ca 2+ storage and release is largely dependent on Ca 2+ handling proteins, such as the SR Ca 2+ ATPase (SERCA2a) pump. During the relaxation phase of the cardiac cycle (diastole), SERCA2a plays a critical role in transporting cytosolic Ca 2+ back to the SR, which helps to restore both cytosolic Ca 2+ levels to their resting state and SR Ca 2+ content for the next contraction. However, decreased SERCA2a expression and/or pump activity are key features in HF. As a result, there is a growing interest in developing therapeutic approaches to target SERCA2a. This review provides an overview of the regulatory mechanisms of the SERCA2a pump and explores potential strategies for SERCA2a-targeted therapy, which are being investigated in both preclinical and clinical studies." @default.
- W4384666261 created "2023-07-20" @default.
- W4384666261 creator A5049106519 @default.
- W4384666261 date "2023-07-18" @default.
- W4384666261 modified "2023-09-26" @default.
- W4384666261 title "Targeting calcium regulators as therapy for heart failure: focus on the sarcoplasmic reticulum Ca-ATPase pump" @default.
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