FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384693229> ?p ?o ?g. }

• W4384693229 abstract "Background Hemorrhagic events can result in significant neurological damage, and identifying effective strategies for neuroprotection is crucial. Several studies have directed their attention to the alterations in perilesional parenchymal tissue. These investigations have sought to modify ischemic and metabolic changes by utilizing potential neuroprotective agents and to develop strategies that effectively mitigate secondary perilesional neuronal damage. By gaining a deeper understanding of its mechanisms and efficacy, Spirulina platensis can emerge as a promising therapeutic intervention for various neurological disorders. Methodology This controlled and blinded experimental study was conducted on adult male Wistar rats. The rats were divided into the treatment group, which received Spirulina platensis extract for 30 days before the hemorrhagic event, and the control group, where all animals underwent the same experimental hemorrhage model using collagenase. Each group was divided into the following three subgroups based on the sacrifice time: six hours, 24 hours, and 30 days. The brain section with the largest hemorrhage volume was selected for histological analysis. The number of viable neurons was analyzed in the perilesional zone and the cortical fields along the puncture trajectory. Neurofunctional evaluations were conducted on animals sacrificed 15 and 30 days after the procedure. Results Initial analysis showed no significant difference in viable neurons between groups (p = 0.63). Still, after 24 hours, the treatment group had a significantly higher number of viable neurons per peripheral fields (18.5) compared to the control group (13.4; p < 0.05). Neurofunctional tests at 15 days indicated a trend toward significance in absolute discrimination (p = 0.054), with the control group showing higher mean values (5.5, SD = 3.1) than the treatment group (-1, SD = 5.1). The discrimination index exhibited a significant difference (p < 0.01), with higher mean values in the control group (0.59, SD = 0.34) compared to the treatment group (-0.05, SD = 0.21). No significant differences were found in other neurofunctional parameters at this time point. At 30 days, no significant differences were observed in absolute discrimination, discrimination index, contralateral paw elevation, rearing time, and wire hanging time test (p > 0.1); however, the treatment group presented a better motor performance in the open field test (14.2, SD = 9.02) compared to the control group (5.25, SD = 2.06), approaching significance (p = 0.06). Conclusions The group treated with Spirulina platensis demonstrated significantly more viable neurons in the perilesional fields 24 hours after the induced hemorrhage. The treatment group also had a relatively better motor performance in the open field test 30 days after the hemorrhage (p = 0.06). These findings suggest a potential neuroprotection effect and warrant further investigations to explore the effects of Spirulina platensis and its active component phycocyanin in acute neurological conditions." @default.
• W4384693229 created "2023-07-20" @default.
• W4384693229 creator A5021788380 @default.
• W4384693229 creator A5051960147 @default.
• W4384693229 creator A5057313316 @default.
• W4384693229 creator A5067452102 @default.
• W4384693229 creator A5083249361 @default.
• W4384693229 creator A5088300037 @default.
• W4384693229 date "2023-07-18" @default.
• W4384693229 modified "2023-10-05" @default.
• W4384693229 title "Exploring the Neuroprotective Effects of Spirulina platensis: Insights Into Hemorrhagic Volume and Histological Outcomes" @default.
• W4384693229 cites W1968092825 @default.
• W4384693229 cites W1970511255 @default.
• W4384693229 cites W1978451359 @default.
• W4384693229 cites W1985210051 @default.
• W4384693229 cites W1989442465 @default.
• W4384693229 cites W1995567109 @default.
• W4384693229 cites W1996003447 @default.
• W4384693229 cites W1996971959 @default.
• W4384693229 cites W2000949542 @default.
• W4384693229 cites W2019867783 @default.
• W4384693229 cites W2027021022 @default.
• W4384693229 cites W2033631648 @default.
• W4384693229 cites W2058323075 @default.
• W4384693229 cites W2074425971 @default.
• W4384693229 cites W2080822311 @default.
• W4384693229 cites W2111118448 @default.
• W4384693229 cites W2116589941 @default.
• W4384693229 cites W2127886120 @default.
• W4384693229 cites W2165406699 @default.
• W4384693229 cites W2288113381 @default.
• W4384693229 cites W2356276233 @default.
• W4384693229 cites W2966426053 @default.
• W4384693229 cites W3028459116 @default.
• W4384693229 cites W3171831654 @default.
• W4384693229 cites W4210821456 @default.
• W4384693229 cites W640892390 @default.
• W4384693229 cites W86067579 @default.
• W4384693229 doi "https://doi.org/10.7759/cureus.42078" @default.
• W4384693229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37602106" @default.
• W4384693229 hasPublicationYear "2023" @default.
• W4384693229 type Work @default.
• W4384693229 citedByCount "0" @default.
• W4384693229 crossrefType "journal-article" @default.
• W4384693229 hasAuthorship W4384693229A5021788380 @default.
• W4384693229 hasAuthorship W4384693229A5051960147 @default.
• W4384693229 hasAuthorship W4384693229A5057313316 @default.
• W4384693229 hasAuthorship W4384693229A5067452102 @default.
• W4384693229 hasAuthorship W4384693229A5083249361 @default.
• W4384693229 hasAuthorship W4384693229A5088300037 @default.
• W4384693229 hasBestOaLocation W43846932291 @default.
• W4384693229 hasConcept C142724271 @default.
• W4384693229 hasConcept C178790620 @default.
• W4384693229 hasConcept C185592680 @default.
• W4384693229 hasConcept C206139338 @default.
• W4384693229 hasConcept C25498285 @default.
• W4384693229 hasConcept C2779784034 @default.
• W4384693229 hasConcept C42407357 @default.
• W4384693229 hasConcept C71924100 @default.
• W4384693229 hasConcept C98274493 @default.
• W4384693229 hasConceptScore W4384693229C142724271 @default.
• W4384693229 hasConceptScore W4384693229C178790620 @default.
• W4384693229 hasConceptScore W4384693229C185592680 @default.
• W4384693229 hasConceptScore W4384693229C206139338 @default.
• W4384693229 hasConceptScore W4384693229C25498285 @default.
• W4384693229 hasConceptScore W4384693229C2779784034 @default.
• W4384693229 hasConceptScore W4384693229C42407357 @default.
• W4384693229 hasConceptScore W4384693229C71924100 @default.
• W4384693229 hasConceptScore W4384693229C98274493 @default.
• W4384693229 hasLocation W43846932291 @default.
• W4384693229 hasLocation W43846932292 @default.
• W4384693229 hasLocation W43846932293 @default.
• W4384693229 hasOpenAccess W4384693229 @default.
• W4384693229 hasPrimaryLocation W43846932291 @default.
• W4384693229 hasRelatedWork W1969617718 @default.
• W4384693229 hasRelatedWork W1993241503 @default.
• W4384693229 hasRelatedWork W2041678827 @default.
• W4384693229 hasRelatedWork W2053629782 @default.
• W4384693229 hasRelatedWork W2083508343 @default.
• W4384693229 hasRelatedWork W2168730925 @default.
• W4384693229 hasRelatedWork W2202599711 @default.
• W4384693229 hasRelatedWork W2692754402 @default.
• W4384693229 hasRelatedWork W4384693229 @default.
• W4384693229 hasRelatedWork W4386645941 @default.
• W4384693229 isParatext "false" @default.
• W4384693229 isRetracted "false" @default.
• W4384693229 workType "article" @default.