Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384693913> ?p ?o ?g. }
- W4384693913 endingPage "1317" @default.
- W4384693913 startingPage "1317" @default.
- W4384693913 abstract "Objective: Accumulating evidence supports neuroprotective effects of regulatory T cells (Tregs) in response to brain injury. However, the precise mechanisms underlying the beneficial effects of Tregs on suppressing neuroinflammation after subarachnoid hemorrhage (SAH) remain unclear. Methods: We performed flow cytometry to detect the infiltration of Tregs into the brain at different time points after SAH. Behavioral tests, including Adhesive and Rotarod, were performed to assess neurological deficits in mice after SAH. Bulk RNA sequencing was used to investigate the transcriptomic change of Tregs infiltrating into the brain after SAH. qPCR was performed to verify the variation of inflammatory cytokines expression in the brain after Tregs exogenous infusion. FoxP3-DTR mice and Il10 gene KO mice were used to explore the mechanism of Tregs inhibiting neuron apoptosis after infiltrating the brain following SAH onset. Results: Peripheral Tregs infiltrated into the brain one day after SAH and gradually accumulated in the hemorrhagic hemisphere. An exogenous infusion of Tregs significantly improved the neurological function of mice after SAH, while poor recovery of neurological function was observed in Tregs depletion mice. Transcriptome sequencing data suggested that the immunosuppressive function of brain-infiltrated Tregs was significantly upregulated. qPCR showed that the expression of pro-inflammatory cytokines decreased in the brain of SAH mice after exogenous Tregs infusion. Bioinformatic analysis revealed that IL-10 and other cytokines secreted by brain-infiltrated Tregs were upregulated after SAH. Moreover, exogenous infusion of Il10 gene KO Tregs did not totally improve neurological function in SAH mice. Conclusions: Tregs infiltrated into the brain in the early stage after SAH and exerted neuroprotective effect by secreting IL-10 to suppress neuroinflammation and reduce neuron apoptosis." @default.
- W4384693913 created "2023-07-20" @default.
- W4384693913 creator A5005410786 @default.
- W4384693913 creator A5013283499 @default.
- W4384693913 creator A5035752408 @default.
- W4384693913 creator A5040665735 @default.
- W4384693913 creator A5043843718 @default.
- W4384693913 creator A5057665345 @default.
- W4384693913 creator A5076647906 @default.
- W4384693913 creator A5079156452 @default.
- W4384693913 date "2023-07-17" @default.
- W4384693913 modified "2023-10-14" @default.
- W4384693913 title "Regulatory T Cells Secrete IL10 to Suppress Neuroinflammation in Early Stage after Subarachnoid Hemorrhage" @default.
- W4384693913 cites W1566992315 @default.
- W4384693913 cites W1946941723 @default.
- W4384693913 cites W1965983192 @default.
- W4384693913 cites W1972414732 @default.
- W4384693913 cites W1977120558 @default.
- W4384693913 cites W1981087357 @default.
- W4384693913 cites W2013900800 @default.
- W4384693913 cites W2018075167 @default.
- W4384693913 cites W2027913805 @default.
- W4384693913 cites W2030284768 @default.
- W4384693913 cites W2032134195 @default.
- W4384693913 cites W2036500213 @default.
- W4384693913 cites W2048766205 @default.
- W4384693913 cites W2062780433 @default.
- W4384693913 cites W2096086497 @default.
- W4384693913 cites W2105104689 @default.
- W4384693913 cites W2114104545 @default.
- W4384693913 cites W2120695828 @default.
- W4384693913 cites W2133428572 @default.
- W4384693913 cites W2137299577 @default.
- W4384693913 cites W2149915530 @default.
- W4384693913 cites W2159103481 @default.
- W4384693913 cites W2165804863 @default.
- W4384693913 cites W2299383924 @default.
- W4384693913 cites W2589232255 @default.
- W4384693913 cites W2595073340 @default.
- W4384693913 cites W2618022450 @default.
- W4384693913 cites W2744368122 @default.
- W4384693913 cites W2765602608 @default.
- W4384693913 cites W2808959710 @default.
- W4384693913 cites W2890911761 @default.
- W4384693913 cites W2950406516 @default.
- W4384693913 cites W2979963107 @default.
- W4384693913 cites W2981100201 @default.
- W4384693913 cites W2987888180 @default.
- W4384693913 cites W2994230480 @default.
- W4384693913 cites W3001334548 @default.
- W4384693913 cites W3005483243 @default.
- W4384693913 cites W3163657510 @default.
- W4384693913 cites W4226094547 @default.
- W4384693913 cites W4234379583 @default.
- W4384693913 cites W4296581473 @default.
- W4384693913 doi "https://doi.org/10.3390/medicina59071317" @default.
- W4384693913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37512128" @default.
- W4384693913 hasPublicationYear "2023" @default.
- W4384693913 type Work @default.
- W4384693913 citedByCount "0" @default.
- W4384693913 crossrefType "journal-article" @default.
- W4384693913 hasAuthorship W4384693913A5005410786 @default.
- W4384693913 hasAuthorship W4384693913A5013283499 @default.
- W4384693913 hasAuthorship W4384693913A5035752408 @default.
- W4384693913 hasAuthorship W4384693913A5040665735 @default.
- W4384693913 hasAuthorship W4384693913A5043843718 @default.
- W4384693913 hasAuthorship W4384693913A5057665345 @default.
- W4384693913 hasAuthorship W4384693913A5076647906 @default.
- W4384693913 hasAuthorship W4384693913A5079156452 @default.
- W4384693913 hasBestOaLocation W43846939131 @default.
- W4384693913 hasConcept C104317684 @default.
- W4384693913 hasConcept C126322002 @default.
- W4384693913 hasConcept C127561419 @default.
- W4384693913 hasConcept C164027704 @default.
- W4384693913 hasConcept C203014093 @default.
- W4384693913 hasConcept C25498285 @default.
- W4384693913 hasConcept C2776914184 @default.
- W4384693913 hasConcept C2777736543 @default.
- W4384693913 hasConcept C2779727006 @default.
- W4384693913 hasConcept C2779830541 @default.
- W4384693913 hasConcept C553184892 @default.
- W4384693913 hasConcept C55493867 @default.
- W4384693913 hasConcept C71924100 @default.
- W4384693913 hasConcept C86803240 @default.
- W4384693913 hasConcept C87753298 @default.
- W4384693913 hasConcept C8891405 @default.
- W4384693913 hasConcept C98274493 @default.
- W4384693913 hasConceptScore W4384693913C104317684 @default.
- W4384693913 hasConceptScore W4384693913C126322002 @default.
- W4384693913 hasConceptScore W4384693913C127561419 @default.
- W4384693913 hasConceptScore W4384693913C164027704 @default.
- W4384693913 hasConceptScore W4384693913C203014093 @default.
- W4384693913 hasConceptScore W4384693913C25498285 @default.
- W4384693913 hasConceptScore W4384693913C2776914184 @default.
- W4384693913 hasConceptScore W4384693913C2777736543 @default.
- W4384693913 hasConceptScore W4384693913C2779727006 @default.
- W4384693913 hasConceptScore W4384693913C2779830541 @default.
- W4384693913 hasConceptScore W4384693913C553184892 @default.