Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384694159> ?p ?o ?g. }
- W4384694159 endingPage "225" @default.
- W4384694159 startingPage "213" @default.
- W4384694159 abstract "Trisomy 21 causes Down syndrome (DS) and is a recognized cause of early-onset Alzheimer's disease (AD).The current study sought to determine if premorbid intellectual disability level (ID) was associated with variability in age-trajectories of AD biomarkers and cognitive impairments. General linear mixed models compared the age-trajectory of the AD biomarkers PET Aβ and tau and cognitive decline across premorbid ID levels (mild, moderate, and severe/profound), in models controlling trisomy type, APOE status, biological sex, and site.Analyses involved adults with DS from the Alzheimer's Biomarkers Consortium-Down Syndrome. Participants completed measures of memory, mental status, and visuospatial ability. Premorbid ID level was based on IQ or mental age scores prior to dementia concerns. PET was acquired using [11C] PiB for Aβ, and [18F] AV-1451 for tau.Cognitive data was available for 361 participants with a mean age of 45.22 (SD = 9.92) and PET biomarker data was available for 154 participants. There was not a significant effect of premorbid ID level by age on cognitive outcomes. There was not a significant effect of premorbid ID by age on PET Aβ or on tau PET. There was not a significant difference in age at time of study visit of those with mild cognitive impairment-DS or dementia by premorbid ID level.Findings provide robust evidence of a similar time course in AD trajectory across premorbid ID levels, laying the groundwork for the inclusion of individuals with DS with a variety of IQ levels in clinical AD trials." @default.
- W4384694159 created "2023-07-20" @default.
- W4384694159 creator A5001794663 @default.
- W4384694159 creator A5008552659 @default.
- W4384694159 creator A5010784943 @default.
- W4384694159 creator A5011455214 @default.
- W4384694159 creator A5013601476 @default.
- W4384694159 creator A5013722818 @default.
- W4384694159 creator A5026870189 @default.
- W4384694159 creator A5036244315 @default.
- W4384694159 creator A5037551360 @default.
- W4384694159 creator A5041742245 @default.
- W4384694159 creator A5053952746 @default.
- W4384694159 creator A5054261106 @default.
- W4384694159 creator A5055450042 @default.
- W4384694159 creator A5055796336 @default.
- W4384694159 creator A5057414041 @default.
- W4384694159 creator A5058610553 @default.
- W4384694159 creator A5067830866 @default.
- W4384694159 creator A5070892687 @default.
- W4384694159 creator A5071138596 @default.
- W4384694159 creator A5076073942 @default.
- W4384694159 creator A5081303009 @default.
- W4384694159 date "2023-08-29" @default.
- W4384694159 modified "2023-10-18" @default.
- W4384694159 title "Timing of Alzheimer’s Disease by Intellectual Disability Level in Down Syndrome" @default.
- W4384694159 cites W1504321825 @default.
- W4384694159 cites W1614664612 @default.
- W4384694159 cites W1776172174 @default.
- W4384694159 cites W1970928383 @default.
- W4384694159 cites W1976863698 @default.
- W4384694159 cites W1988247542 @default.
- W4384694159 cites W1996014567 @default.
- W4384694159 cites W1996765504 @default.
- W4384694159 cites W2061847630 @default.
- W4384694159 cites W2075409615 @default.
- W4384694159 cites W2077067735 @default.
- W4384694159 cites W2080793450 @default.
- W4384694159 cites W2088540084 @default.
- W4384694159 cites W2101135654 @default.
- W4384694159 cites W2124030567 @default.
- W4384694159 cites W2136145485 @default.
- W4384694159 cites W2156582981 @default.
- W4384694159 cites W2168153179 @default.
- W4384694159 cites W2171250577 @default.
- W4384694159 cites W2529649944 @default.
- W4384694159 cites W2727088999 @default.
- W4384694159 cites W2755594069 @default.
- W4384694159 cites W2773828216 @default.
- W4384694159 cites W2786198454 @default.
- W4384694159 cites W2914706199 @default.
- W4384694159 cites W2922531184 @default.
- W4384694159 cites W2971155263 @default.
- W4384694159 cites W3003016857 @default.
- W4384694159 cites W3038008717 @default.
- W4384694159 cites W3199416333 @default.
- W4384694159 cites W3205749467 @default.
- W4384694159 cites W4230705678 @default.
- W4384694159 cites W4253870456 @default.
- W4384694159 cites W4281388023 @default.
- W4384694159 cites W4289939358 @default.
- W4384694159 cites W4312087748 @default.
- W4384694159 cites W4364377639 @default.
- W4384694159 cites W623907223 @default.
- W4384694159 cites W67683392 @default.
- W4384694159 doi "https://doi.org/10.3233/jad-230200" @default.
- W4384694159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37482997" @default.
- W4384694159 hasPublicationYear "2023" @default.
- W4384694159 type Work @default.
- W4384694159 citedByCount "0" @default.
- W4384694159 crossrefType "journal-article" @default.
- W4384694159 hasAuthorship W4384694159A5001794663 @default.
- W4384694159 hasAuthorship W4384694159A5008552659 @default.
- W4384694159 hasAuthorship W4384694159A5010784943 @default.
- W4384694159 hasAuthorship W4384694159A5011455214 @default.
- W4384694159 hasAuthorship W4384694159A5013601476 @default.
- W4384694159 hasAuthorship W4384694159A5013722818 @default.
- W4384694159 hasAuthorship W4384694159A5026870189 @default.
- W4384694159 hasAuthorship W4384694159A5036244315 @default.
- W4384694159 hasAuthorship W4384694159A5037551360 @default.
- W4384694159 hasAuthorship W4384694159A5041742245 @default.
- W4384694159 hasAuthorship W4384694159A5053952746 @default.
- W4384694159 hasAuthorship W4384694159A5054261106 @default.
- W4384694159 hasAuthorship W4384694159A5055450042 @default.
- W4384694159 hasAuthorship W4384694159A5055796336 @default.
- W4384694159 hasAuthorship W4384694159A5057414041 @default.
- W4384694159 hasAuthorship W4384694159A5058610553 @default.
- W4384694159 hasAuthorship W4384694159A5067830866 @default.
- W4384694159 hasAuthorship W4384694159A5070892687 @default.
- W4384694159 hasAuthorship W4384694159A5071138596 @default.
- W4384694159 hasAuthorship W4384694159A5076073942 @default.
- W4384694159 hasAuthorship W4384694159A5081303009 @default.
- W4384694159 hasBestOaLocation W43846941591 @default.
- W4384694159 hasConcept C118552586 @default.
- W4384694159 hasConcept C126322002 @default.
- W4384694159 hasConcept C15744967 @default.
- W4384694159 hasConcept C169900460 @default.
- W4384694159 hasConcept C185592680 @default.