Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384694828> ?p ?o ?g. }
- W4384694828 abstract "Calcium (Ca2+) uptake by mitochondria is essential in regulating bioenergetics, cell death, and cytosolic Ca2+ transients. Mitochondrial Calcium Uniporter (MCU) mediates the mitochondrial Ca2+ uptake. MCU is a hetero-oligomeric complex with a pore-forming component and accessory proteins required for channel activity. Though MCU regulation by MICUs is unequivocally established, there needs to be more knowledge of whether divalent cations regulate MCU. Here we set out to understand the mitochondrial matrix Mg2+-dependent regulation of MCU activity. We showed Mrs2 as the authentic mammalian mitochondrial Mg2+ channel using the planar lipid bilayer recordings. Using a liver-specific Mrs2 KO mouse model, we showed that decreased matrix [Mg2+] is associated with increased MCU activity and matrix Ca2+ overload. The disruption of Mg2+-dependent MCU regulation significantly prompted mitochondrial permeability transition pore opening-mediated cell death during tissue IR injury. Our findings support a critical role for mMg2+ in regulating MCU activity and attenuating mCa2+ overload." @default.
- W4384694828 created "2023-07-20" @default.
- W4384694828 creator A5008551356 @default.
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- W4384694828 creator A5086842583 @default.
- W4384694828 date "2023-07-18" @default.
- W4384694828 modified "2023-10-03" @default.
- W4384694828 title "Mitochondrial Magnesium is the cationic rheostat for MCU-mediated mitochondrial Ca2+ uptake" @default.
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