Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384694892> ?p ?o ?g. }
- W4384694892 endingPage "8278" @default.
- W4384694892 startingPage "8278" @default.
- W4384694892 abstract "Background: The molecular crosstalk between periodontitis and diabetes is well established. The role of the NLRP3 inflammasome, a multicomponent inflammatory machinery, is an emerging field of research on the relationship between these two uncommunicable diseases. Recent advances are revealing further molecular details regarding the biological function and the mechanism behind the NLRP3 inflammasome dysregulation and highlighting an unexpected role for the caspase-1 in immune homeostasis. We aimed to understand which metabolic checkpoints are involved in contributing to and instigating the relationship between periodontitis and diabetes. We tried to explore the involvement of the NLRP3 in regulating the cytokine-chemokines profile and discussed the potential synergism in these mechanisms when these two diseases coexist in the same patient. Methods: A literature search was carried out in the electronic databases (MEDLINE, EMBASE, and Cochrane Library) for relevant studies from inception until January 2022 for trials and cohort studies that investigated the activation and regulation mechanism of the NLRP3 inflammasome in patients with periodontitis and type two diabetes. Two investigators independently extracted data. The data quality assessment was rated by the Joanna Briggs Institute (JBI). Results: from twenty-six references identified, three studies (two case-control and one cross-sectional) met the inclusion criteria. Analysis of periodontal tissue samples in diabetic individuals exhibited significant overexpression of the NLRP3 inflammasome when compared with healthy controls. Conclusions: there is insufficient evidence to sustain the involvement of the upregulation of genes and proteins involved in the activation of NLRP3 inflammasome components in patients with periodontitis and diabetes." @default.
- W4384694892 created "2023-07-20" @default.
- W4384694892 creator A5009017571 @default.
- W4384694892 creator A5025407753 @default.
- W4384694892 creator A5045965638 @default.
- W4384694892 creator A5074561273 @default.
- W4384694892 creator A5076030420 @default.
- W4384694892 creator A5083193969 @default.
- W4384694892 creator A5086756126 @default.
- W4384694892 date "2023-07-18" @default.
- W4384694892 modified "2023-09-27" @default.
- W4384694892 title "Mechanism behind the Upregulation of Proteins Associated with the NLRP3 Inflammasome in Periodontitis and Their Role in the Immune Response in Diabetes—A Systematic Review" @default.
- W4384694892 cites W1588757730 @default.
- W4384694892 cites W1993602103 @default.
- W4384694892 cites W2004932936 @default.
- W4384694892 cites W2013013478 @default.
- W4384694892 cites W2015449243 @default.
- W4384694892 cites W2030455404 @default.
- W4384694892 cites W2068870934 @default.
- W4384694892 cites W2107104312 @default.
- W4384694892 cites W2149984336 @default.
- W4384694892 cites W2164450207 @default.
- W4384694892 cites W2165796078 @default.
- W4384694892 cites W2187931582 @default.
- W4384694892 cites W2279357322 @default.
- W4384694892 cites W2364450135 @default.
- W4384694892 cites W2521126557 @default.
- W4384694892 cites W2549780172 @default.
- W4384694892 cites W2566221061 @default.
- W4384694892 cites W2589187779 @default.
- W4384694892 cites W2605402511 @default.
- W4384694892 cites W2767188829 @default.
- W4384694892 cites W2794232859 @default.
- W4384694892 cites W2795245657 @default.
- W4384694892 cites W2803535434 @default.
- W4384694892 cites W2884445384 @default.
- W4384694892 cites W2897037806 @default.
- W4384694892 cites W2915252464 @default.
- W4384694892 cites W2916299755 @default.
- W4384694892 cites W2943293743 @default.
- W4384694892 cites W2954782052 @default.
- W4384694892 cites W2955355528 @default.
- W4384694892 cites W2964512159 @default.
- W4384694892 cites W2982061867 @default.
- W4384694892 cites W2991821439 @default.
- W4384694892 cites W3024073346 @default.
- W4384694892 cites W3040960482 @default.
- W4384694892 cites W3046388141 @default.
- W4384694892 cites W3080228553 @default.
- W4384694892 cites W3092052734 @default.
- W4384694892 cites W3115816194 @default.
- W4384694892 cites W3118615836 @default.
- W4384694892 cites W3119724580 @default.
- W4384694892 cites W3127989634 @default.
- W4384694892 cites W3137714176 @default.
- W4384694892 cites W3153624090 @default.
- W4384694892 cites W3175752789 @default.
- W4384694892 cites W4225607898 @default.
- W4384694892 cites W4294151229 @default.
- W4384694892 cites W4295903151 @default.
- W4384694892 cites W4311399847 @default.
- W4384694892 cites W4365136207 @default.
- W4384694892 doi "https://doi.org/10.3390/app13148278" @default.
- W4384694892 hasPublicationYear "2023" @default.
- W4384694892 type Work @default.
- W4384694892 citedByCount "0" @default.
- W4384694892 crossrefType "journal-article" @default.
- W4384694892 hasAuthorship W4384694892A5009017571 @default.
- W4384694892 hasAuthorship W4384694892A5025407753 @default.
- W4384694892 hasAuthorship W4384694892A5045965638 @default.
- W4384694892 hasAuthorship W4384694892A5074561273 @default.
- W4384694892 hasAuthorship W4384694892A5076030420 @default.
- W4384694892 hasAuthorship W4384694892A5083193969 @default.
- W4384694892 hasAuthorship W4384694892A5086756126 @default.
- W4384694892 hasBestOaLocation W43846948921 @default.
- W4384694892 hasConcept C111472728 @default.
- W4384694892 hasConcept C126322002 @default.
- W4384694892 hasConcept C134018914 @default.
- W4384694892 hasConcept C138885662 @default.
- W4384694892 hasConcept C203014093 @default.
- W4384694892 hasConcept C2776478404 @default.
- W4384694892 hasConcept C2776914184 @default.
- W4384694892 hasConcept C2777209026 @default.
- W4384694892 hasConcept C2780385504 @default.
- W4384694892 hasConcept C555293320 @default.
- W4384694892 hasConcept C60644358 @default.
- W4384694892 hasConcept C71924100 @default.
- W4384694892 hasConcept C86803240 @default.
- W4384694892 hasConcept C8891405 @default.
- W4384694892 hasConcept C89611455 @default.
- W4384694892 hasConcept C95190672 @default.
- W4384694892 hasConceptScore W4384694892C111472728 @default.
- W4384694892 hasConceptScore W4384694892C126322002 @default.
- W4384694892 hasConceptScore W4384694892C134018914 @default.
- W4384694892 hasConceptScore W4384694892C138885662 @default.
- W4384694892 hasConceptScore W4384694892C203014093 @default.
- W4384694892 hasConceptScore W4384694892C2776478404 @default.
- W4384694892 hasConceptScore W4384694892C2776914184 @default.