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- W4384694931 abstract "p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes pathogenesis. However, how p-cresol affects gut hormones is unclear. Here, we expose immortalized GLUTag cells to increasing concentrations of p-cresol and found that p-cresol inhibited Gcg expression and reduced glucagon-like peptide-1 (GLP-1) secretion in vitro. In mice, administration of p-cresol in the drinking water for 2 weeks reduced the transcript levels of Gcg and other gut hormones in the colon; however, it did not affect either fasting or glucose-induced plasma GLP-1 levels. Furthermore, it did not affect glucose tolerance but promoted faster small intestinal transit in mice. Overall, our data suggest that microbial metabolite p-cresol suppresses transcript levels of gut hormones and regulates small intestinal transit in mice." @default.
- W4384694931 created "2023-07-20" @default.
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- W4384694931 date "2023-07-18" @default.
- W4384694931 modified "2023-10-16" @default.
- W4384694931 title "Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice" @default.
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- W4384694931 doi "https://doi.org/10.3389/fendo.2023.1200391" @default.
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