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• W4384694955 endingPage "1456" @default.
• W4384694955 startingPage "1456" @default.
• W4384694955 abstract "Atopic dermatitis (AD) has been extensively investigated for genetic associations utilizing both candidate gene approaches and genome-wide scans. Here, we comprehensively evaluated the available literature to determine the association of candidate genes in AD to gain additional insight into the etiopathogenesis of the disease. We systematically screened all studies that explored the association between polymorphisms and AD risks in cases of European and Asian ancestry and synthesized the available evidence through a random-effects meta-analysis. We identified 99 studies that met our inclusion/exclusion criteria that examined 17 candidate loci in Europeans and 14 candidate genes in Asians. We confirmed the significant associations between FLG variants in both European and Asian populations and AD risk, while synthesis of the available data revealed novel loci mapped to IL18 and TGFB1 genes in Europeans and IL12RB1 and MIF in Asians that have not yet been identified by genome-wide association studies. Our findings provide comprehensive evidence for AD risk loci in cases of both European and Asian ancestries, validating previous associations as well as revealing novel loci that could imply previously unexplored biological pathways." @default.
• W4384694955 created "2023-07-20" @default.
• W4384694955 creator A5017688841 @default.
• W4384694955 creator A5080996416 @default.
• W4384694955 creator A5090286688 @default.
• W4384694955 creator A5092257378 @default.
• W4384694955 date "2023-07-17" @default.
• W4384694955 modified "2023-09-26" @default.
• W4384694955 title "Candidate Gene Association Studies in Atopic Dermatitis in Participants of European and Asian Ancestry: A Systematic Review and Meta-Analysis" @default.
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