Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384695209> ?p ?o ?g. }
- W4384695209 abstract "Introduction Adipokines are proteins that are secreted by the adipose tissue. Although they are associated with obesity-related metabolic disorders, most studies have focused on adipokines expressed by visceral adipose tissue (VAT). This study aimed to identify the adipokine potentially derived from subcutaneous adipose tissue (SAT) and its clinical significance. Methods Samples of SAT and VAT were obtained from six adult male patients who underwent laparoscopic surgery for benign gall bladder disease. Differentially expressed genes were analyzed by subjecting the samples to RNA sequencing. The serum concentration of selected proteins according to body mass index (BMI) was analyzed in 58 individuals. Results GDF10 showed significantly higher expression in the SAT, as per RNA sequencing (fold change = 5.8, adjusted P value = 0.009). Genes related to insulin response, glucose homeostasis, lipid homeostasis, and fatty acid metabolism were suppressed when GDF10 expression was high in SAT, as per genotype-tissue expression data. The serum GDF10 concentration was higher in participants with BMI ≥ 25 kg/m 2 (n = 35, 2674 ± 441 pg/mL) than in those with BMI < 25 kg/m 2 (n = 23, 2339 ± 639 pg/mL; P = 0.022). There was a positive correlation between BMI and serum GDF10 concentration (r = 0.308, P = 0.019). Conclusions GDF10 expression was higher in SAT than in VAT. Serum GDF10 concentration was high in patients with obesity. Therefore, GDF10 could be a SAT-derived protein related to obesity." @default.
- W4384695209 created "2023-07-20" @default.
- W4384695209 creator A5033606569 @default.
- W4384695209 creator A5043562284 @default.
- W4384695209 creator A5047070923 @default.
- W4384695209 creator A5055782937 @default.
- W4384695209 creator A5060716452 @default.
- W4384695209 creator A5063018523 @default.
- W4384695209 creator A5066524201 @default.
- W4384695209 creator A5077466654 @default.
- W4384695209 creator A5087387214 @default.
- W4384695209 date "2023-07-14" @default.
- W4384695209 modified "2023-10-14" @default.
- W4384695209 title "GDF10 is related to obesity as an adipokine derived from subcutaneous adipose tissue" @default.
- W4384695209 cites W1940950287 @default.
- W4384695209 cites W1973438927 @default.
- W4384695209 cites W1978912394 @default.
- W4384695209 cites W1979527677 @default.
- W4384695209 cites W1981509058 @default.
- W4384695209 cites W1989400130 @default.
- W4384695209 cites W1991079474 @default.
- W4384695209 cites W2000532842 @default.
- W4384695209 cites W2034893482 @default.
- W4384695209 cites W2049397413 @default.
- W4384695209 cites W2066613779 @default.
- W4384695209 cites W2076027601 @default.
- W4384695209 cites W2086823329 @default.
- W4384695209 cites W2102278945 @default.
- W4384695209 cites W2104005232 @default.
- W4384695209 cites W2112024733 @default.
- W4384695209 cites W2119519672 @default.
- W4384695209 cites W2140886368 @default.
- W4384695209 cites W2156877200 @default.
- W4384695209 cites W2170651583 @default.
- W4384695209 cites W2179438025 @default.
- W4384695209 cites W2343081039 @default.
- W4384695209 cites W2510875395 @default.
- W4384695209 cites W2579485914 @default.
- W4384695209 cites W2591570422 @default.
- W4384695209 cites W2916288948 @default.
- W4384695209 cites W2955946374 @default.
- W4384695209 cites W2978687867 @default.
- W4384695209 cites W3042136278 @default.
- W4384695209 cites W3123695042 @default.
- W4384695209 cites W3135577702 @default.
- W4384695209 cites W3208814196 @default.
- W4384695209 doi "https://doi.org/10.3389/fendo.2023.1159515" @default.
- W4384695209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37529611" @default.
- W4384695209 hasPublicationYear "2023" @default.
- W4384695209 type Work @default.
- W4384695209 citedByCount "0" @default.
- W4384695209 crossrefType "journal-article" @default.
- W4384695209 hasAuthorship W4384695209A5033606569 @default.
- W4384695209 hasAuthorship W4384695209A5043562284 @default.
- W4384695209 hasAuthorship W4384695209A5047070923 @default.
- W4384695209 hasAuthorship W4384695209A5055782937 @default.
- W4384695209 hasAuthorship W4384695209A5060716452 @default.
- W4384695209 hasAuthorship W4384695209A5063018523 @default.
- W4384695209 hasAuthorship W4384695209A5066524201 @default.
- W4384695209 hasAuthorship W4384695209A5077466654 @default.
- W4384695209 hasAuthorship W4384695209A5087387214 @default.
- W4384695209 hasBestOaLocation W43846952091 @default.
- W4384695209 hasConcept C126322002 @default.
- W4384695209 hasConcept C134018914 @default.
- W4384695209 hasConcept C171089720 @default.
- W4384695209 hasConcept C194832188 @default.
- W4384695209 hasConcept C2777391703 @default.
- W4384695209 hasConcept C2780221984 @default.
- W4384695209 hasConcept C2908640109 @default.
- W4384695209 hasConcept C4733338 @default.
- W4384695209 hasConcept C511355011 @default.
- W4384695209 hasConcept C63645605 @default.
- W4384695209 hasConcept C71924100 @default.
- W4384695209 hasConcept C86803240 @default.
- W4384695209 hasConceptScore W4384695209C126322002 @default.
- W4384695209 hasConceptScore W4384695209C134018914 @default.
- W4384695209 hasConceptScore W4384695209C171089720 @default.
- W4384695209 hasConceptScore W4384695209C194832188 @default.
- W4384695209 hasConceptScore W4384695209C2777391703 @default.
- W4384695209 hasConceptScore W4384695209C2780221984 @default.
- W4384695209 hasConceptScore W4384695209C2908640109 @default.
- W4384695209 hasConceptScore W4384695209C4733338 @default.
- W4384695209 hasConceptScore W4384695209C511355011 @default.
- W4384695209 hasConceptScore W4384695209C63645605 @default.
- W4384695209 hasConceptScore W4384695209C71924100 @default.
- W4384695209 hasConceptScore W4384695209C86803240 @default.
- W4384695209 hasFunder F4320322120 @default.
- W4384695209 hasLocation W43846952091 @default.
- W4384695209 hasLocation W43846952092 @default.
- W4384695209 hasLocation W43846952093 @default.
- W4384695209 hasOpenAccess W4384695209 @default.
- W4384695209 hasPrimaryLocation W43846952091 @default.
- W4384695209 hasRelatedWork W1782957512 @default.
- W4384695209 hasRelatedWork W1964688190 @default.
- W4384695209 hasRelatedWork W1976234278 @default.
- W4384695209 hasRelatedWork W2027098794 @default.
- W4384695209 hasRelatedWork W2049045125 @default.
- W4384695209 hasRelatedWork W2081564223 @default.
- W4384695209 hasRelatedWork W2086591008 @default.
- W4384695209 hasRelatedWork W2167541966 @default.