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- W4384695210 abstract "Cannabinoid subtype 1 receptors (CB 1 Rs) are an important class of G protein-coupled receptors (GPCRs) belonging to the endocannabinoid system. CB 1 Rs play a crucial modulatory role in the functioning of other neurotransmitter systems and are involved in a wide range of physiological functions and dysfunctions; thus, they are considered one of the most important targets for drug development, as well as diagnostic purposes. Despite this, only a few molecules targeting this receptor are available on the pharmaceutical market, thus emphasizing the need to gain a deeper understanding of the complex activation pathways of CB 1 Rs and how they regulate diseases. As part of this review, we provide an overview of pharmacological and imaging tools useful for detecting CB 1 Rs. Herein, we summarize the derivations of cannabinoids and terpenoids with fluorescent compounds, radiotracers, or photochromic motifs. CB 1 Rs’ molecular probes may be used in vitro and, in some cases, in vivo for investigating and exploring the roles of CB 1 Rs together with the starting point for the development of CB 1 R-targeted drugs." @default.
- W4384695210 created "2023-07-20" @default.
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- W4384695210 date "2023-07-18" @default.
- W4384695210 modified "2023-10-07" @default.
- W4384695210 title "Recent advances in the development of CB1R selective probes" @default.
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- W4384695210 doi "https://doi.org/10.3389/fntpr.2023.1196321" @default.
- W4384695210 hasPublicationYear "2023" @default.
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