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- W4384695361 abstract "Major depressive disorder (MDD) is a disabling mental disorder characterized by negative mood and suicidality. The NMDA antagonist ketamine has been found to reduce depressive symptoms and suicidal thoughts in patients unresponsive to first-line antidepressants, but ketamine’s mechanism of action remains unclear. More women are diagnosed with MDD than men and present with greater suicidal ideation, but it is unclear if there are sex-dependent responses to ketamine. It was recently determined that activating mRNA translation via phosphorylation of the eukaryotic initiation factor 4E binding proteins (4E-BPs) is a crucial mechanism of ketamine’s antidepressant effect in non-stressed male mice. The aim is to understand if stressed females also engage this mechanism following ketamine treatment. After investigating whether 4E-BP1 and 4E-BP2 are relevant to ketamine’s antidepressant mechanisms of action in female mice, the present study’s findings are inconclusive, as ketamine had no effect on several chronic variable stress-induced behaviors in tested mice." @default.
- W4384695361 created "2023-07-20" @default.
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- W4384695361 date "2023-07-18" @default.
- W4384695361 modified "2023-09-27" @default.
- W4384695361 title "Sex Differences in the Antidepressant Effects of Ketamine" @default.
- W4384695361 doi "https://doi.org/10.22215/etd/2023-15485" @default.
- W4384695361 hasPublicationYear "2023" @default.
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