FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384695384> ?p ?o ?g. }

• W4384695384 abstract "Abstract Lipopolysaccharides (LPS) of Gram-negative bacteria are mediators of neuroinflammation and neurodegeneration that have been detected in close association with aggregations of brain amyloid beta (Aβ) and microtubule-associated protein tau (MAPT). LPS induce the release of cytokines by microglia, the residing immune cells of the brain, and mediate the upregulation of inducible nitric oxide synthase (iNOS) – a mechanism associated with amyloidosis and MAPT destabilization. Curcumin is a natural product possessing several medicinal effects; however, its pharmaceutical exploitation is hindered by low bioavailability. V-Cur, a novel hemocompatible Vanadium (IV)-curcumin complex with higher solubility and pharmaceutical activity than curcumin, has been employed in the present study. Mixed cultures of primary rat brain neurons and microglia stimulated LPS presented increased levels of amyloid precursor protein (APP), an effect inhibited by either curcumin or V-Cur. V-Cur was also proved a more potent inhibitor of amyloid aggregation than curcumin, by both insulin aggregation assay and in silico studies. Cell stimulation with LPS increased full-length, inactivated, and total iNOS levels, and the inflammation markers IL-1β and TNF-α. Both curcumin and V-Cur alleviated these effects, with V-Cur reducing iNOS levels more than curcumin, whereas curcumin and V-Cur increased the MAPT levels in LPS-stimulated cells. Complementary insights into possible bioactivity mechanisms of both curcumin and V-Cur were provided by in silico molecular docking calculations on iNOS, TNF-α, IL-1β, Aβ 1−42 , APP and Aβ fibrils. This study renders curcumin-based compounds a promising anti-inflammatory intervention that may be proven a strong tool in the effort to mitigate neurodegenerative disease pathology and neuroinflammatory conditions." @default.
• W4384695384 created "2023-07-20" @default.
• W4384695384 creator A5024337465 @default.
• W4384695384 creator A5033922780 @default.
• W4384695384 creator A5036094154 @default.
• W4384695384 creator A5055622508 @default.
• W4384695384 creator A5067856978 @default.
• W4384695384 creator A5073653550 @default.
• W4384695384 creator A5087439695 @default.
• W4384695384 date "2023-07-18" @default.
• W4384695384 modified "2023-09-23" @default.
• W4384695384 title "In vitro and in silico evaluation of the anti-amyloid and anti-inflammatory properties of curcumin and a V (IV) – curcumin complex in LPS-stimulated primary rat neurons-microglia mixed cultures" @default.
• W4384695384 cites W147870220 @default.
• W4384695384 cites W1508289240 @default.
• W4384695384 cites W1519936974 @default.
• W4384695384 cites W1546841942 @default.
• W4384695384 cites W1603278131 @default.
• W4384695384 cites W1882862737 @default.
• W4384695384 cites W1967968285 @default.
• W4384695384 cites W1969641027 @default.
• W4384695384 cites W1976129006 @default.
• W4384695384 cites W1976194786 @default.
• W4384695384 cites W1976301160 @default.
• W4384695384 cites W1976856337 @default.
• W4384695384 cites W1985717888 @default.
• W4384695384 cites W1988718057 @default.
• W4384695384 cites W1990350348 @default.
• W4384695384 cites W2001380334 @default.
• W4384695384 cites W2003223057 @default.
• W4384695384 cites W2011666658 @default.
• W4384695384 cites W2013585426 @default.
• W4384695384 cites W2017088635 @default.
• W4384695384 cites W2018880174 @default.
• W4384695384 cites W2023136593 @default.
• W4384695384 cites W2032169317 @default.
• W4384695384 cites W2038119237 @default.
• W4384695384 cites W2041238959 @default.
• W4384695384 cites W2045253296 @default.
• W4384695384 cites W2046645259 @default.
• W4384695384 cites W2046818023 @default.
• W4384695384 cites W2048400917 @default.
• W4384695384 cites W2049730142 @default.
• W4384695384 cites W2050094645 @default.
• W4384695384 cites W2057349526 @default.
• W4384695384 cites W2057913943 @default.
• W4384695384 cites W2061419556 @default.
• W4384695384 cites W2067574216 @default.
• W4384695384 cites W2069893872 @default.
• W4384695384 cites W2073301191 @default.
• W4384695384 cites W2076362385 @default.
• W4384695384 cites W2076918198 @default.
• W4384695384 cites W2083670710 @default.
• W4384695384 cites W2085959631 @default.
• W4384695384 cites W2096158347 @default.
• W4384695384 cites W2096410114 @default.
• W4384695384 cites W2096963202 @default.
• W4384695384 cites W2099157718 @default.
• W4384695384 cites W2099540110 @default.
• W4384695384 cites W2101108802 @default.
• W4384695384 cites W2103440561 @default.
• W4384695384 cites W2107282184 @default.
• W4384695384 cites W2108629610 @default.
• W4384695384 cites W2115873969 @default.
• W4384695384 cites W2127511592 @default.
• W4384695384 cites W2131847864 @default.
• W4384695384 cites W2135348375 @default.
• W4384695384 cites W2138282068 @default.
• W4384695384 cites W2141309011 @default.
• W4384695384 cites W2148059849 @default.
• W4384695384 cites W2150149802 @default.
• W4384695384 cites W2153574154 @default.
• W4384695384 cites W2159879659 @default.
• W4384695384 cites W2162390271 @default.
• W4384695384 cites W2166977775 @default.
• W4384695384 cites W2170025328 @default.
• W4384695384 cites W2171314958 @default.
• W4384695384 cites W2312776799 @default.
• W4384695384 cites W2341430323 @default.
• W4384695384 cites W2358666620 @default.
• W4384695384 cites W2410229905 @default.
• W4384695384 cites W2422578359 @default.
• W4384695384 cites W2436653758 @default.
• W4384695384 cites W2517700447 @default.
• W4384695384 cites W2524578182 @default.
• W4384695384 cites W2527645962 @default.
• W4384695384 cites W2566006671 @default.
• W4384695384 cites W2725377723 @default.
• W4384695384 cites W2734651019 @default.
• W4384695384 cites W2735061629 @default.
• W4384695384 cites W2740213823 @default.
• W4384695384 cites W2752981360 @default.
• W4384695384 cites W2756259362 @default.
• W4384695384 cites W2761210275 @default.
• W4384695384 cites W2766083858 @default.
• W4384695384 cites W2767312268 @default.
• W4384695384 cites W2793412161 @default.
• W4384695384 cites W2793729844 @default.
• W4384695384 cites W2801804366 @default.
• W4384695384 cites W2892261244 @default.
• W4384695384 cites W2899892160 @default.

• next