FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384695767> ?p ?o ?g. }

• W4384695767 endingPage "9" @default.
• W4384695767 startingPage "1" @default.
• W4384695767 abstract "Background. Pediatric Type 2 diabetes (T2D) is highly heterogeneous. Previous reports on adult-onset diabetes demonstrated the existence of diabetes clusters. Therefore, we set out to identify unique diabetes subgroups with distinct characteristics among youth with T2D using commonly available demographic, clinical, and biochemical data. Methods. We performed data-driven cluster analysis (K-prototypes clustering) to characterize diabetes subtypes in pediatrics using a dataset with 722 children and adolescents with autoantibody-negative T2D. The six variables included in our analysis were sex, race/ethnicity, age, BMI Z-score and hemoglobin A1c at the time of diagnosis, and non-HDL cholesterol within first year of diagnosis. Results. We identified five distinct clusters of pediatric T2D, with different features, treatment regimens and risk of diabetes complications: Cluster 1 was characterized by higher A1c; Cluster 2, by higher non-HDL; Cluster 3, by lower age at diagnosis and lower A1c; Cluster 4, by lower BMI and higher A1c; and Cluster 5, by lower A1c and higher age. Youth in Cluster 1 had the highest rate of diabetic ketoacidosis (DKA) ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>p</mi> <mo>=</mo> <mn>0.0001</mn> </math> ) and were most prescribed metformin ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>p</mi> <mo>=</mo> <mn>0.06</mn> </math> ). Those in Cluster 2 were most prone to polycystic ovarian syndrome ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>p</mi> <mo>=</mo> <mn>0.001</mn> </math> ). Younger individuals with lowest family history of diabetes were least frequently diagnosed with diabetic ketoacidosis ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>p</mi> <mo>=</mo> <mn>0.001</mn> </math> ) and microalbuminuria ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>p</mi> <mo>=</mo> <mn>0.06</mn> </math> ). Low-BMI individuals with higher A1c had the lowest prevalence of acanthosis nigricans ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mi>p</mi> <mo>=</mo> <mn>0.0003</mn> </math> ) and hypertension ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mi>p</mi> <mo>=</mo> <mn>0.03</mn> </math> ). Conclusions. Utilizing clinical measures gathered at the time of diabetes diagnosis can be used to identify subgroups of pediatric T2D with prognostic value. Consequently, this advancement contributes to the progression and wider implementation of precision medicine in diabetes management." @default.
• W4384695767 created "2023-07-20" @default.
• W4384695767 creator A5025937610 @default.
• W4384695767 creator A5025974153 @default.
• W4384695767 creator A5049140753 @default.
• W4384695767 creator A5053303129 @default.
• W4384695767 creator A5072109473 @default.
• W4384695767 creator A5083852795 @default.
• W4384695767 date "2023-07-18" @default.
• W4384695767 modified "2023-09-26" @default.
• W4384695767 title "Clinical Characterization of Data-Driven Diabetes Clusters of Pediatric Type 2 Diabetes" @default.
• W4384695767 cites W110489919 @default.
• W4384695767 cites W1955323283 @default.
• W4384695767 cites W2028283466 @default.
• W4384695767 cites W2045105153 @default.
• W4384695767 cites W2056399290 @default.
• W4384695767 cites W2066245509 @default.
• W4384695767 cites W2085365463 @default.
• W4384695767 cites W2096466744 @default.
• W4384695767 cites W2114515328 @default.
• W4384695767 cites W2115098571 @default.
• W4384695767 cites W2130880600 @default.
• W4384695767 cites W2149230623 @default.
• W4384695767 cites W2158516160 @default.
• W4384695767 cites W2160570104 @default.
• W4384695767 cites W2168052502 @default.
• W4384695767 cites W2169072681 @default.
• W4384695767 cites W2340898396 @default.
• W4384695767 cites W2480680997 @default.
• W4384695767 cites W2500800419 @default.
• W4384695767 cites W2548003739 @default.
• W4384695767 cites W2766577489 @default.
• W4384695767 cites W2790501791 @default.
• W4384695767 cites W2890555481 @default.
• W4384695767 cites W2955542625 @default.
• W4384695767 cites W2964211103 @default.
• W4384695767 cites W2983074022 @default.
• W4384695767 cites W2999944081 @default.
• W4384695767 cites W3024284236 @default.
• W4384695767 cites W3081422974 @default.
• W4384695767 cites W3081675739 @default.
• W4384695767 cites W3085504648 @default.
• W4384695767 cites W3092828784 @default.
• W4384695767 cites W3150993251 @default.
• W4384695767 cites W3179572571 @default.
• W4384695767 cites W3188243017 @default.
• W4384695767 cites W3195466285 @default.
• W4384695767 cites W3206761891 @default.
• W4384695767 cites W4200547640 @default.
• W4384695767 cites W4230870013 @default.
• W4384695767 cites W4241883936 @default.
• W4384695767 cites W4297183832 @default.
• W4384695767 cites W4311264067 @default.
• W4384695767 doi "https://doi.org/10.1155/2023/6955723" @default.
• W4384695767 hasPublicationYear "2023" @default.
• W4384695767 type Work @default.
• W4384695767 citedByCount "0" @default.
• W4384695767 crossrefType "journal-article" @default.
• W4384695767 hasAuthorship W4384695767A5025937610 @default.
• W4384695767 hasAuthorship W4384695767A5025974153 @default.
• W4384695767 hasAuthorship W4384695767A5049140753 @default.
• W4384695767 hasAuthorship W4384695767A5053303129 @default.
• W4384695767 hasAuthorship W4384695767A5072109473 @default.
• W4384695767 hasAuthorship W4384695767A5083852795 @default.
• W4384695767 hasBestOaLocation W43846957671 @default.
• W4384695767 hasConcept C126322002 @default.
• W4384695767 hasConcept C134018914 @default.
• W4384695767 hasConcept C164866538 @default.
• W4384695767 hasConcept C187212893 @default.
• W4384695767 hasConcept C199360897 @default.
• W4384695767 hasConcept C2777180221 @default.
• W4384695767 hasConcept C2780323712 @default.
• W4384695767 hasConcept C2781232474 @default.
• W4384695767 hasConcept C2781283889 @default.
• W4384695767 hasConcept C41008148 @default.
• W4384695767 hasConcept C555293320 @default.
• W4384695767 hasConcept C71924100 @default.
• W4384695767 hasConceptScore W4384695767C126322002 @default.
• W4384695767 hasConceptScore W4384695767C134018914 @default.
• W4384695767 hasConceptScore W4384695767C164866538 @default.
• W4384695767 hasConceptScore W4384695767C187212893 @default.
• W4384695767 hasConceptScore W4384695767C199360897 @default.
• W4384695767 hasConceptScore W4384695767C2777180221 @default.
• W4384695767 hasConceptScore W4384695767C2780323712 @default.
• W4384695767 hasConceptScore W4384695767C2781232474 @default.
• W4384695767 hasConceptScore W4384695767C2781283889 @default.
• W4384695767 hasConceptScore W4384695767C41008148 @default.
• W4384695767 hasConceptScore W4384695767C555293320 @default.
• W4384695767 hasConceptScore W4384695767C71924100 @default.
• W4384695767 hasFunder F4320332161 @default.
• W4384695767 hasLocation W43846957671 @default.
• W4384695767 hasOpenAccess W4384695767 @default.
• W4384695767 hasPrimaryLocation W43846957671 @default.
• W4384695767 hasRelatedWork W2000571139 @default.
• W4384695767 hasRelatedWork W2011278875 @default.
• W4384695767 hasRelatedWork W2040473170 @default.
• W4384695767 hasRelatedWork W2373544290 @default.
• W4384695767 hasRelatedWork W2618920464 @default.

• next