FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384696536> ?p ?o ?g. }

• W4384696536 endingPage "846" @default.
• W4384696536 startingPage "846" @default.
• W4384696536 abstract "<ns4:p><ns4:bold>Background</ns4:bold>: One of the most common neurodegenerative diseases is Parkinson’s disease (PD); PD is characterized by a reduction of neurons containing dopamine in the substantia nigra (SN), which leads to a lack of dopamine (DA) in nigrostriatal pathways, resulting in motor function disorders. Oxidative stress is considered as one of the etiologies involved in dopaminergic neuronal loss. Thus, we aimed to investigate the neuroprotective effects of pinostrobin (PB), a bioflavonoid extracted from <ns4:italic>Boesenbergia rotunda </ns4:italic>with antioxidative activity in PD.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: Rats were treated with 40 mg/kg of PB for seven consecutive days before and after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD. After completing the experiment, the brains including SN and striatum were used for histological studies and biochemical assays.</ns4:p><ns4:p> <ns4:bold>Results</ns4:bold>: PB treatment demonstrated a reduction of free radicals in the SN as indicated by significantly decreased MDA levels, whereas the antioxidative enzymes (SOD and GSH) were significantly increased. Furthermore, PB treatment significantly increased glial cell line-derived neurotrophic factor (GDNF) immunolabelling which has neurotrophic and neuroprotective effects on the survival of dopaminergic neurons. Furthermore, PB treatment was shown to protect CA1 and CA3 neurons in the hippocampus and dopaminergic neurons in the SN. DA levels in the SN were increased after PB treatment, leading to the improvement of motor function of PD rats.</ns4:p><ns4:p> <ns4:bold>Conclusions</ns4:bold>: These results imply that PB prevents MPTP-induced neurotoxicity via its antioxidant activities and increases GDNF levels, which may contribute to the therapeutic strategy for PD.</ns4:p>" @default.
• W4384696536 created "2023-07-20" @default.
• W4384696536 creator A5004881679 @default.
• W4384696536 creator A5043082016 @default.
• W4384696536 creator A5048781984 @default.
• W4384696536 creator A5056704556 @default.
• W4384696536 creator A5067734162 @default.
• W4384696536 creator A5071656757 @default.
• W4384696536 date "2023-07-18" @default.
• W4384696536 modified "2023-10-18" @default.
• W4384696536 title "Pinostrobin mitigates neurodegeneration through an up-regulation of antioxidants and GDNF in a rat model of Parkinson’s disease" @default.
• W4384696536 cites W1588182583 @default.
• W4384696536 cites W1775749144 @default.
• W4384696536 cites W1966702161 @default.
• W4384696536 cites W1966860657 @default.
• W4384696536 cites W1972420008 @default.
• W4384696536 cites W1973455163 @default.
• W4384696536 cites W1978593678 @default.
• W4384696536 cites W1986789422 @default.
• W4384696536 cites W1998885927 @default.
• W4384696536 cites W2002405028 @default.
• W4384696536 cites W2048490376 @default.
• W4384696536 cites W2068049440 @default.
• W4384696536 cites W2068786448 @default.
• W4384696536 cites W2070914201 @default.
• W4384696536 cites W2077212548 @default.
• W4384696536 cites W2078341790 @default.
• W4384696536 cites W2086241311 @default.
• W4384696536 cites W2089644973 @default.
• W4384696536 cites W2107632774 @default.
• W4384696536 cites W2110402724 @default.
• W4384696536 cites W2133831383 @default.
• W4384696536 cites W2157199780 @default.
• W4384696536 cites W2164457608 @default.
• W4384696536 cites W2526973717 @default.
• W4384696536 cites W2584311212 @default.
• W4384696536 cites W2628638289 @default.
• W4384696536 cites W2804611742 @default.
• W4384696536 cites W2807047688 @default.
• W4384696536 cites W2811210174 @default.
• W4384696536 cites W2831688134 @default.
• W4384696536 cites W2906111512 @default.
• W4384696536 cites W2929323304 @default.
• W4384696536 cites W2939723392 @default.
• W4384696536 cites W3123279413 @default.
• W4384696536 cites W3129009349 @default.
• W4384696536 cites W3170558317 @default.
• W4384696536 cites W4205162772 @default.
• W4384696536 cites W4293340336 @default.
• W4384696536 cites W4319000633 @default.
• W4384696536 cites W4322581269 @default.
• W4384696536 doi "https://doi.org/10.12688/f1000research.134891.1" @default.
• W4384696536 hasPublicationYear "2023" @default.
• W4384696536 type Work @default.
• W4384696536 citedByCount "0" @default.
• W4384696536 crossrefType "journal-article" @default.
• W4384696536 hasAuthorship W4384696536A5004881679 @default.
• W4384696536 hasAuthorship W4384696536A5043082016 @default.
• W4384696536 hasAuthorship W4384696536A5048781984 @default.
• W4384696536 hasAuthorship W4384696536A5056704556 @default.
• W4384696536 hasAuthorship W4384696536A5067734162 @default.
• W4384696536 hasAuthorship W4384696536A5071656757 @default.
• W4384696536 hasBestOaLocation W43846965361 @default.
• W4384696536 hasConcept C126322002 @default.
• W4384696536 hasConcept C134018914 @default.
• W4384696536 hasConcept C137183658 @default.
• W4384696536 hasConcept C160539049 @default.
• W4384696536 hasConcept C169760540 @default.
• W4384696536 hasConcept C170493617 @default.
• W4384696536 hasConcept C185856081 @default.
• W4384696536 hasConcept C25498285 @default.
• W4384696536 hasConcept C2776151105 @default.
• W4384696536 hasConcept C2776925932 @default.
• W4384696536 hasConcept C2778674702 @default.
• W4384696536 hasConcept C2779134260 @default.
• W4384696536 hasConcept C2779734285 @default.
• W4384696536 hasConcept C2780938664 @default.
• W4384696536 hasConcept C43310041 @default.
• W4384696536 hasConcept C513476851 @default.
• W4384696536 hasConcept C71924100 @default.
• W4384696536 hasConcept C86803240 @default.
• W4384696536 hasConceptScore W4384696536C126322002 @default.
• W4384696536 hasConceptScore W4384696536C134018914 @default.
• W4384696536 hasConceptScore W4384696536C137183658 @default.
• W4384696536 hasConceptScore W4384696536C160539049 @default.
• W4384696536 hasConceptScore W4384696536C169760540 @default.
• W4384696536 hasConceptScore W4384696536C170493617 @default.
• W4384696536 hasConceptScore W4384696536C185856081 @default.
• W4384696536 hasConceptScore W4384696536C25498285 @default.
• W4384696536 hasConceptScore W4384696536C2776151105 @default.
• W4384696536 hasConceptScore W4384696536C2776925932 @default.
• W4384696536 hasConceptScore W4384696536C2778674702 @default.
• W4384696536 hasConceptScore W4384696536C2779134260 @default.
• W4384696536 hasConceptScore W4384696536C2779734285 @default.
• W4384696536 hasConceptScore W4384696536C2780938664 @default.
• W4384696536 hasConceptScore W4384696536C43310041 @default.
• W4384696536 hasConceptScore W4384696536C513476851 @default.
• W4384696536 hasConceptScore W4384696536C71924100 @default.

• next