Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384697148> ?p ?o ?g. }
- W4384697148 abstract "ABSTRACT Degradable polymeric micelles are promising drug delivery systems due to their hydrophobic core and responsive design. When applying micellar nanocarriers for tumor delivery, one of the bottlenecks encountered in vivo is the tumor tissue barrier – crossing the dense mesh of cells and extracellular matrix (ECM). Sometimes overlooked, the extracellular matrix can trap nanoformulations based on charge, size and hydrophobicity. Here we used a simple design of a microfluidic chip with two types of ECM and MCF7 spheroids to allow “high throughput” screening of the interactions between biological interfaces and polymeric micelles. To demostrarte the applicapility of the chip, a small library of fluorescently labelled polymeric micelles varying in their hydrophilic shell and hydrophobic core forming blocks was studied. Three widely used hydrophilic shells were tested and compared, poly(ethylene glycol), poly(2-ethyl-2-oxazoline), and poly(acrylic acid), along with two enzyamticaly degradable dendritic hydrophobic cores (based on Hexyl or Nonyl end-gorups). Using ratiometric imaging of unimer:micelle fluorescence and FRAP inside the chip model, we obtained the local assembly state and dynamics inside the chip. Notably, we observed different micelle behaviors in the basal lamina ECM, from avoidance of ECM structure to binding of the poly(acrylic acid) formulations. Binding to basal lamina correlated with higher uptake into MCF7 spheroids. Overall, we proposed a simple microfluidic chip containing dual ECM and spheroids for the assessment of the interactions of polymeric nanocarrires with biological interfaces and evaluating nanoformulations’ capacity to cross the tumor tissue barrier." @default.
- W4384697148 created "2023-07-20" @default.
- W4384697148 creator A5000973433 @default.
- W4384697148 creator A5036759439 @default.
- W4384697148 creator A5056233427 @default.
- W4384697148 creator A5065127369 @default.
- W4384697148 creator A5066976932 @default.
- W4384697148 creator A5068741057 @default.
- W4384697148 creator A5071405653 @default.
- W4384697148 creator A5077500990 @default.
- W4384697148 creator A5087190788 @default.
- W4384697148 date "2023-07-18" @default.
- W4384697148 modified "2023-10-07" @default.
- W4384697148 title "Reaching the tumor: mobility of polymeric micelles inside an<i>in vitro</i>tumor-on-a-chip model with dual ECM" @default.
- W4384697148 cites W1919685122 @default.
- W4384697148 cites W2015530052 @default.
- W4384697148 cites W2031512142 @default.
- W4384697148 cites W2056229778 @default.
- W4384697148 cites W2062357348 @default.
- W4384697148 cites W2063976599 @default.
- W4384697148 cites W2083710155 @default.
- W4384697148 cites W2100687920 @default.
- W4384697148 cites W2120212141 @default.
- W4384697148 cites W2132566055 @default.
- W4384697148 cites W2145539666 @default.
- W4384697148 cites W2150516757 @default.
- W4384697148 cites W2160908941 @default.
- W4384697148 cites W2167279371 @default.
- W4384697148 cites W2169398513 @default.
- W4384697148 cites W2493571000 @default.
- W4384697148 cites W2563587937 @default.
- W4384697148 cites W2614943507 @default.
- W4384697148 cites W2766249461 @default.
- W4384697148 cites W2808585456 @default.
- W4384697148 cites W2811467107 @default.
- W4384697148 cites W2891593440 @default.
- W4384697148 cites W2944552251 @default.
- W4384697148 cites W3082566257 @default.
- W4384697148 cites W3085018979 @default.
- W4384697148 cites W3114177293 @default.
- W4384697148 cites W3121957226 @default.
- W4384697148 cites W3143710170 @default.
- W4384697148 cites W3191975273 @default.
- W4384697148 cites W4230362574 @default.
- W4384697148 cites W4317905177 @default.
- W4384697148 doi "https://doi.org/10.1101/2023.07.14.548885" @default.
- W4384697148 hasPublicationYear "2023" @default.
- W4384697148 type Work @default.
- W4384697148 citedByCount "0" @default.
- W4384697148 crossrefType "posted-content" @default.
- W4384697148 hasAuthorship W4384697148A5000973433 @default.
- W4384697148 hasAuthorship W4384697148A5036759439 @default.
- W4384697148 hasAuthorship W4384697148A5056233427 @default.
- W4384697148 hasAuthorship W4384697148A5065127369 @default.
- W4384697148 hasAuthorship W4384697148A5066976932 @default.
- W4384697148 hasAuthorship W4384697148A5068741057 @default.
- W4384697148 hasAuthorship W4384697148A5071405653 @default.
- W4384697148 hasAuthorship W4384697148A5077500990 @default.
- W4384697148 hasAuthorship W4384697148A5087190788 @default.
- W4384697148 hasBestOaLocation W43846971481 @default.
- W4384697148 hasConcept C11268172 @default.
- W4384697148 hasConcept C12554922 @default.
- W4384697148 hasConcept C142724271 @default.
- W4384697148 hasConcept C15920480 @default.
- W4384697148 hasConcept C171250308 @default.
- W4384697148 hasConcept C178790620 @default.
- W4384697148 hasConcept C18150654 @default.
- W4384697148 hasConcept C184651966 @default.
- W4384697148 hasConcept C185592680 @default.
- W4384697148 hasConcept C189165786 @default.
- W4384697148 hasConcept C192562407 @default.
- W4384697148 hasConcept C2777516009 @default.
- W4384697148 hasConcept C2779333224 @default.
- W4384697148 hasConcept C2779820397 @default.
- W4384697148 hasConcept C2780503075 @default.
- W4384697148 hasConcept C521977710 @default.
- W4384697148 hasConcept C55493867 @default.
- W4384697148 hasConcept C71924100 @default.
- W4384697148 hasConcept C86803240 @default.
- W4384697148 hasConcept C87555872 @default.
- W4384697148 hasConceptScore W4384697148C11268172 @default.
- W4384697148 hasConceptScore W4384697148C12554922 @default.
- W4384697148 hasConceptScore W4384697148C142724271 @default.
- W4384697148 hasConceptScore W4384697148C15920480 @default.
- W4384697148 hasConceptScore W4384697148C171250308 @default.
- W4384697148 hasConceptScore W4384697148C178790620 @default.
- W4384697148 hasConceptScore W4384697148C18150654 @default.
- W4384697148 hasConceptScore W4384697148C184651966 @default.
- W4384697148 hasConceptScore W4384697148C185592680 @default.
- W4384697148 hasConceptScore W4384697148C189165786 @default.
- W4384697148 hasConceptScore W4384697148C192562407 @default.
- W4384697148 hasConceptScore W4384697148C2777516009 @default.
- W4384697148 hasConceptScore W4384697148C2779333224 @default.
- W4384697148 hasConceptScore W4384697148C2779820397 @default.
- W4384697148 hasConceptScore W4384697148C2780503075 @default.
- W4384697148 hasConceptScore W4384697148C521977710 @default.
- W4384697148 hasConceptScore W4384697148C55493867 @default.
- W4384697148 hasConceptScore W4384697148C71924100 @default.
- W4384697148 hasConceptScore W4384697148C86803240 @default.
- W4384697148 hasConceptScore W4384697148C87555872 @default.