FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384697407> ?p ?o ?g. }

• W4384697407 abstract "Abstract The standardized uptake value ratio (SUVR) is used to measure Aβ uptake in PET images of the brain. Variations in PET scanner technologies and image reconstruction techniques can lead to variability in images acquired from different scanners. This poses a challenge for Aβ-PET studies conducted across multiple centers. The aim of harmonization is to achieve consistent Aβ-PET measurements across scanners. In this study, the procedure of matching the spatial resolution of a barrel phantom measured in each PET scanner is proposed as a method of Aβ-PET harmonization, validated using subject data. Methods Three different PET scanners were used: the Siemens Biograph Vision 600, Siemens Biograph mCT, and Philips Gemini TF64. A total of five, eight, and five subjects were each scanned twice with [ 18 F]-NAV4694 across Vision-mCT, mCT-Philips, and Vision-Philips scanner pairs. The Vision and mCT scans were reconstructed using various iterations, subsets, and post-reconstruction Gaussian smoothing, while one reconstruction configuration was used for the Philips scans. The full-width at half-maximum (FWHM) of each reconstruction configuration was calculated using [ 18 F]-filled barrel phantom scans with the SNMMI phantom analysis toolkit. Regional SUVRs were calculated from 72 brain regions using the AAL3 atlas for each subject and reconstruction configuration. Statistical similarity between SUVRs was assessed using paired (within subject) t-tests for each pair of reconstructions across scanners; the higher the p-value, the greater the similarity between the SUVRs. Results Vision-mCT harmonization maximal statistical similarity (i.e., p -value) between regional SUVRs was achieved using a 4.10 mm FWHM Vision reconstruction with a 4.30 mm FWHM mCT reconstruction. Philips-mCT harmonization maximal statistical similarity between regional SUVRs was achieved using an 8.2 mm FWHM Philips reconstruction with a 9.35 mm FWHM mCT reconstruction. Philips-Vision harmonization a 9.1 mm FWHM Vision reconstruction had maximum statistical similarity with regional SUVRs from an 8.2mm FWHM Philips reconstruction. Reconstruction pairs that maximized statistical similarity, and supported a null hypothesis of being drawn from the same distribution, were selected as harmonised for each scanner pair. Conclusion Using data obtained from three sets of participants, each scanned on a different pair of PET scanners, using reconstruction configurations with matched barrel phantom spatial resolutions, we have demonstrated that Aβ-PET quantitation can be harmonised across scanners, producing SUVR values statistically likely to be drawn from the same distribution. This finding is encouraging for the use of different PET scanners in multi-centre trials, or updates during longitudinal studies." @default.
• W4384697407 created "2023-07-20" @default.
• W4384697407 creator A5022818431 @default.
• W4384697407 creator A5034024417 @default.
• W4384697407 creator A5039611632 @default.
• W4384697407 creator A5047385288 @default.
• W4384697407 creator A5051996588 @default.
• W4384697407 creator A5075897962 @default.
• W4384697407 date "2023-07-18" @default.
• W4384697407 modified "2023-09-23" @default.
• W4384697407 title "Inter-scanner Aβ-amyloid PET harmonization using barrel phantom spatial resolution matching" @default.
• W4384697407 cites W1600129465 @default.
• W4384697407 cites W1916193671 @default.
• W4384697407 cites W2040174321 @default.
• W4384697407 cites W2044614452 @default.
• W4384697407 cites W2049231321 @default.
• W4384697407 cites W2064173428 @default.
• W4384697407 cites W2074427084 @default.
• W4384697407 cites W2088783247 @default.
• W4384697407 cites W2095272243 @default.
• W4384697407 cites W2124030567 @default.
• W4384697407 cites W2140652743 @default.
• W4384697407 cites W2144646585 @default.
• W4384697407 cites W2281211957 @default.
• W4384697407 cites W2487877762 @default.
• W4384697407 cites W2773306697 @default.
• W4384697407 cites W2807971451 @default.
• W4384697407 cites W2888048543 @default.
• W4384697407 cites W2973007151 @default.
• W4384697407 cites W3127622022 @default.
• W4384697407 doi "https://doi.org/10.1101/2023.07.16.23292733" @default.
• W4384697407 hasPublicationYear "2023" @default.
• W4384697407 type Work @default.
• W4384697407 citedByCount "0" @default.
• W4384697407 crossrefType "posted-content" @default.
• W4384697407 hasAuthorship W4384697407A5022818431 @default.
• W4384697407 hasAuthorship W4384697407A5034024417 @default.
• W4384697407 hasAuthorship W4384697407A5039611632 @default.
• W4384697407 hasAuthorship W4384697407A5047385288 @default.
• W4384697407 hasAuthorship W4384697407A5051996588 @default.
• W4384697407 hasAuthorship W4384697407A5075897962 @default.
• W4384697407 hasBestOaLocation W43846974071 @default.
• W4384697407 hasConcept C103278499 @default.
• W4384697407 hasConcept C104293457 @default.
• W4384697407 hasConcept C115961682 @default.
• W4384697407 hasConcept C154945302 @default.
• W4384697407 hasConcept C199374082 @default.
• W4384697407 hasConcept C205372480 @default.
• W4384697407 hasConcept C2775842073 @default.
• W4384697407 hasConcept C2779751349 @default.
• W4384697407 hasConcept C2989005 @default.
• W4384697407 hasConcept C31972630 @default.
• W4384697407 hasConcept C41008148 @default.
• W4384697407 hasConcept C71924100 @default.
• W4384697407 hasConceptScore W4384697407C103278499 @default.
• W4384697407 hasConceptScore W4384697407C104293457 @default.
• W4384697407 hasConceptScore W4384697407C115961682 @default.
• W4384697407 hasConceptScore W4384697407C154945302 @default.
• W4384697407 hasConceptScore W4384697407C199374082 @default.
• W4384697407 hasConceptScore W4384697407C205372480 @default.
• W4384697407 hasConceptScore W4384697407C2775842073 @default.
• W4384697407 hasConceptScore W4384697407C2779751349 @default.
• W4384697407 hasConceptScore W4384697407C2989005 @default.
• W4384697407 hasConceptScore W4384697407C31972630 @default.
• W4384697407 hasConceptScore W4384697407C41008148 @default.
• W4384697407 hasConceptScore W4384697407C71924100 @default.
• W4384697407 hasLocation W43846974071 @default.
• W4384697407 hasOpenAccess W4384697407 @default.
• W4384697407 hasPrimaryLocation W43846974071 @default.
• W4384697407 hasRelatedWork W1969496878 @default.
• W4384697407 hasRelatedWork W1991553034 @default.
• W4384697407 hasRelatedWork W2044788131 @default.
• W4384697407 hasRelatedWork W2111347914 @default.
• W4384697407 hasRelatedWork W2158762347 @default.
• W4384697407 hasRelatedWork W2179301249 @default.
• W4384697407 hasRelatedWork W2778298633 @default.
• W4384697407 hasRelatedWork W2900723815 @default.
• W4384697407 hasRelatedWork W96407372 @default.
• W4384697407 hasRelatedWork W2043379292 @default.
• W4384697407 isParatext "false" @default.
• W4384697407 isRetracted "false" @default.
• W4384697407 workType "article" @default.