Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384697498> ?p ?o ?g. }
- W4384697498 abstract "Abstract Previously, the presence of a blood-myenteric plexus barrier and its disruption was reported in experimentally induced colitis via a macrophage-dependent process. The aim of this study is to reveal how myenteric barrier disruption and subsequent neuronal injury affects gut motility in vivo in a murine colitis model. We induced experimental colitis with dextran sulfate sodium (DSS), with the co-administration of liposome-encapsulated clodronate (L-clodronate) to deplete muscularis macrophages (MMs) in male mice. DSS-treated animals receiving concurrent L-clodronate injection showed significantly decreased MM-density compared to DSS-treated control (DSS-vehicle). DSS-clodronate-treated mice exhibited significantly slower whole gut transit time than DSS-vehicle-treated animals and comparable to that of controls. Experiments with oral gavage-fed Evans-blue dye show similar whole gut transit times in DSS-clodronate-treated mice as in control animals. Furthermore, qPCR-analysis on colon muscularis samples revealed that factors associated with neuroinflammation and neurodegeneration are overexpressed after DSS-treatment, but not in the case of concurrent L-clodronate administration. Our findings highlight that MM-infiltration in the muscularis layer is responsible for colitis-associated dysmotility and enteric neuronal dysfunction along with the release of mediators associated with neurodegeneration in a murine experimental model." @default.
- W4384697498 created "2023-07-20" @default.
- W4384697498 creator A5009327689 @default.
- W4384697498 creator A5015256065 @default.
- W4384697498 creator A5016137378 @default.
- W4384697498 creator A5030361070 @default.
- W4384697498 creator A5041499764 @default.
- W4384697498 creator A5066209110 @default.
- W4384697498 creator A5071006771 @default.
- W4384697498 creator A5073339612 @default.
- W4384697498 creator A5075514749 @default.
- W4384697498 creator A5077412380 @default.
- W4384697498 date "2023-07-18" @default.
- W4384697498 modified "2023-10-16" @default.
- W4384697498 title "Depletion of Muscularis Macrophages Ameliorates Inflammation- driven Dysmotility in Murine Colitis Model" @default.
- W4384697498 cites W1904500917 @default.
- W4384697498 cites W1978748245 @default.
- W4384697498 cites W1985442766 @default.
- W4384697498 cites W1988729253 @default.
- W4384697498 cites W1993262247 @default.
- W4384697498 cites W1995965793 @default.
- W4384697498 cites W2003596017 @default.
- W4384697498 cites W2005158904 @default.
- W4384697498 cites W2011859476 @default.
- W4384697498 cites W2027052432 @default.
- W4384697498 cites W2027654243 @default.
- W4384697498 cites W2042966900 @default.
- W4384697498 cites W2050708805 @default.
- W4384697498 cites W2054264840 @default.
- W4384697498 cites W2056490358 @default.
- W4384697498 cites W2073342372 @default.
- W4384697498 cites W2084961602 @default.
- W4384697498 cites W2087367550 @default.
- W4384697498 cites W2096411324 @default.
- W4384697498 cites W2105818495 @default.
- W4384697498 cites W2107370389 @default.
- W4384697498 cites W2126263479 @default.
- W4384697498 cites W2143066408 @default.
- W4384697498 cites W2157020351 @default.
- W4384697498 cites W2166150070 @default.
- W4384697498 cites W2232938630 @default.
- W4384697498 cites W2292066171 @default.
- W4384697498 cites W2343451480 @default.
- W4384697498 cites W2570429698 @default.
- W4384697498 cites W2602278063 @default.
- W4384697498 cites W2751237807 @default.
- W4384697498 cites W2755548020 @default.
- W4384697498 cites W2763922502 @default.
- W4384697498 cites W2766046358 @default.
- W4384697498 cites W2768014540 @default.
- W4384697498 cites W2783252066 @default.
- W4384697498 cites W2788480107 @default.
- W4384697498 cites W2791790536 @default.
- W4384697498 cites W2800195991 @default.
- W4384697498 cites W2804230186 @default.
- W4384697498 cites W2883037857 @default.
- W4384697498 cites W2939717249 @default.
- W4384697498 cites W2969452448 @default.
- W4384697498 cites W2979626005 @default.
- W4384697498 cites W3016969729 @default.
- W4384697498 cites W3024742609 @default.
- W4384697498 cites W3100699824 @default.
- W4384697498 cites W3109154857 @default.
- W4384697498 cites W3109449637 @default.
- W4384697498 cites W3119118230 @default.
- W4384697498 cites W3155099403 @default.
- W4384697498 cites W3172106555 @default.
- W4384697498 cites W3180122961 @default.
- W4384697498 cites W4313545500 @default.
- W4384697498 cites W4317358846 @default.
- W4384697498 cites W4365816222 @default.
- W4384697498 cites W4380550685 @default.
- W4384697498 doi "https://doi.org/10.21203/rs.3.rs-3114660/v1" @default.
- W4384697498 hasPublicationYear "2023" @default.
- W4384697498 type Work @default.
- W4384697498 citedByCount "0" @default.
- W4384697498 crossrefType "posted-content" @default.
- W4384697498 hasAuthorship W4384697498A5009327689 @default.
- W4384697498 hasAuthorship W4384697498A5015256065 @default.
- W4384697498 hasAuthorship W4384697498A5016137378 @default.
- W4384697498 hasAuthorship W4384697498A5030361070 @default.
- W4384697498 hasAuthorship W4384697498A5041499764 @default.
- W4384697498 hasAuthorship W4384697498A5066209110 @default.
- W4384697498 hasAuthorship W4384697498A5071006771 @default.
- W4384697498 hasAuthorship W4384697498A5073339612 @default.
- W4384697498 hasAuthorship W4384697498A5075514749 @default.
- W4384697498 hasAuthorship W4384697498A5077412380 @default.
- W4384697498 hasBestOaLocation W43846974981 @default.
- W4384697498 hasConcept C126322002 @default.
- W4384697498 hasConcept C142724271 @default.
- W4384697498 hasConcept C150903083 @default.
- W4384697498 hasConcept C185592680 @default.
- W4384697498 hasConcept C204232928 @default.
- W4384697498 hasConcept C207001950 @default.
- W4384697498 hasConcept C2775862500 @default.
- W4384697498 hasConcept C2776907353 @default.
- W4384697498 hasConcept C2776914184 @default.
- W4384697498 hasConcept C2776925932 @default.
- W4384697498 hasConcept C2777043163 @default.
- W4384697498 hasConcept C2777649898 @default.