Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384697718> ?p ?o ?g. }
- W4384697718 abstract "Abstract Purpose: Diabetes mellitus (DM) is the second most common comorbidity in myelodysplastic syndromes (MDS). The purpose of the study was to investigate the clinical characteristics of MDS patients with DM. Methods: A retrospective analysis was performed on the clinical data of 958 MDS patients with and without DM. Clinical data, including genetic changes, overall survival (OS), leukemia-free survival (LFS) and infection, were analyzed. Results: Among 958 patients, 202 (21.1%) had DM. TET2 and SF3B1 mutations occurred more frequently in the DM group than in the non-DM group (p = 0.0124 and p = 0.0009, respectively). Compared to non-DM patients, MDS patients with DM had poor OS and LFS (p < 0.0001 and p = 0.0003, respectively), especially in the lower-risk group. In multivariate analysis, DM independently predicted OS (HR 1.369 CI 1.078-1.738, p = 0.010). Meanwhile, DM was an independent risk factor for bacterial infection (HR 2.055 CI 1.415-2.984, p = 0.000) and fungal infection (HR 2.146 CI 1.422-3.238, p = 0.000) in MDS. Conclusions: MDS patients with DM have an inferior prognosis and higher infection incidence, with TET2 and SF3B1 mutations being more frequent in those cases." @default.
- W4384697718 created "2023-07-20" @default.
- W4384697718 creator A5005280399 @default.
- W4384697718 creator A5006247153 @default.
- W4384697718 creator A5008474735 @default.
- W4384697718 creator A5011645302 @default.
- W4384697718 creator A5016410321 @default.
- W4384697718 creator A5016656766 @default.
- W4384697718 creator A5017218508 @default.
- W4384697718 creator A5020965606 @default.
- W4384697718 creator A5024203788 @default.
- W4384697718 creator A5042263308 @default.
- W4384697718 creator A5042282374 @default.
- W4384697718 creator A5045199115 @default.
- W4384697718 creator A5049872422 @default.
- W4384697718 creator A5057448809 @default.
- W4384697718 creator A5062749373 @default.
- W4384697718 creator A5071709424 @default.
- W4384697718 creator A5084297512 @default.
- W4384697718 creator A5089605876 @default.
- W4384697718 date "2023-07-18" @default.
- W4384697718 modified "2023-09-30" @default.
- W4384697718 title "The clinical characteristics, gene mutations and outcomes of myelodysplastic syndromes with diabetes mellitus" @default.
- W4384697718 cites W1500301819 @default.
- W4384697718 cites W1971476868 @default.
- W4384697718 cites W1978793505 @default.
- W4384697718 cites W1991988380 @default.
- W4384697718 cites W2021343620 @default.
- W4384697718 cites W2028702466 @default.
- W4384697718 cites W2051726694 @default.
- W4384697718 cites W2054855682 @default.
- W4384697718 cites W2103020543 @default.
- W4384697718 cites W2108739937 @default.
- W4384697718 cites W2129580665 @default.
- W4384697718 cites W2140106230 @default.
- W4384697718 cites W2143876560 @default.
- W4384697718 cites W2145408452 @default.
- W4384697718 cites W2155850922 @default.
- W4384697718 cites W2164199686 @default.
- W4384697718 cites W2171553260 @default.
- W4384697718 cites W2472752337 @default.
- W4384697718 cites W2585807002 @default.
- W4384697718 cites W2606906244 @default.
- W4384697718 cites W2752384709 @default.
- W4384697718 cites W2768820368 @default.
- W4384697718 cites W2796018590 @default.
- W4384697718 cites W2810093671 @default.
- W4384697718 cites W2884558319 @default.
- W4384697718 cites W2896742268 @default.
- W4384697718 cites W2936041668 @default.
- W4384697718 cites W2937993724 @default.
- W4384697718 cites W2945990270 @default.
- W4384697718 cites W2976907750 @default.
- W4384697718 cites W3001584947 @default.
- W4384697718 cites W3014587554 @default.
- W4384697718 cites W3017704884 @default.
- W4384697718 cites W3020528808 @default.
- W4384697718 cites W3042113602 @default.
- W4384697718 cites W3047204205 @default.
- W4384697718 cites W3094666465 @default.
- W4384697718 cites W3165876965 @default.
- W4384697718 cites W3197283370 @default.
- W4384697718 cites W3198358363 @default.
- W4384697718 cites W3212430506 @default.
- W4384697718 cites W4210845036 @default.
- W4384697718 cites W4225273647 @default.
- W4384697718 doi "https://doi.org/10.21203/rs.3.rs-3167076/v1" @default.
- W4384697718 hasPublicationYear "2023" @default.
- W4384697718 type Work @default.
- W4384697718 citedByCount "0" @default.
- W4384697718 crossrefType "posted-content" @default.
- W4384697718 hasAuthorship W4384697718A5005280399 @default.
- W4384697718 hasAuthorship W4384697718A5006247153 @default.
- W4384697718 hasAuthorship W4384697718A5008474735 @default.
- W4384697718 hasAuthorship W4384697718A5011645302 @default.
- W4384697718 hasAuthorship W4384697718A5016410321 @default.
- W4384697718 hasAuthorship W4384697718A5016656766 @default.
- W4384697718 hasAuthorship W4384697718A5017218508 @default.
- W4384697718 hasAuthorship W4384697718A5020965606 @default.
- W4384697718 hasAuthorship W4384697718A5024203788 @default.
- W4384697718 hasAuthorship W4384697718A5042263308 @default.
- W4384697718 hasAuthorship W4384697718A5042282374 @default.
- W4384697718 hasAuthorship W4384697718A5045199115 @default.
- W4384697718 hasAuthorship W4384697718A5049872422 @default.
- W4384697718 hasAuthorship W4384697718A5057448809 @default.
- W4384697718 hasAuthorship W4384697718A5062749373 @default.
- W4384697718 hasAuthorship W4384697718A5071709424 @default.
- W4384697718 hasAuthorship W4384697718A5084297512 @default.
- W4384697718 hasAuthorship W4384697718A5089605876 @default.
- W4384697718 hasBestOaLocation W43846977181 @default.
- W4384697718 hasConcept C120665830 @default.
- W4384697718 hasConcept C121332964 @default.
- W4384697718 hasConcept C126322002 @default.
- W4384697718 hasConcept C134018914 @default.
- W4384697718 hasConcept C143998085 @default.
- W4384697718 hasConcept C167135981 @default.
- W4384697718 hasConcept C2779159551 @default.
- W4384697718 hasConcept C2780007613 @default.
- W4384697718 hasConcept C2780817109 @default.
- W4384697718 hasConcept C38180746 @default.