FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384698677> ?p ?o ?g. }

• W4384698677 endingPage "147" @default.
• W4384698677 startingPage "144" @default.
• W4384698677 abstract "BACKGROUND Dyspnea is an extremely prevalent and debilitating symptom in chronic obstructive pulmonary disease (COPD), affecting up to 74% of patients despite optimal medical therapy. Sublingual fentanyl citrate (SLF) has a fast onset of action and a short half-life, both interesting characteristics to treat acute breakthrough dyspnea without inducing metabolite accumulation. The Montreal Chest Institute (MCI) COPD specialty clinic has been using low-dose SLF for patients with advanced COPD experiencing significant episodic dyspnea despite high intensity inhaled therapy. We present here a retrospective chart review, the largest to date, to report on a “real life” experience.METHODS All included patients had a formal diagnosis of COPD and were seen in the MCI COPD specialty clinic between January 1, 2015 and January 1, 2021. All patients prescribed SLF, irrespective of the duration of use, were enrolled in this chart review. Extent of symptom relief, categorized into either major, intermediate or no improvements, and adverse effects were inferred from in-person or telephone follow-up appointment clinical notes. An exacerbation was defined as a self-reported acute increase in symptoms leading to oral corticosteroid use or hospitalization. Rates of exacerbation and hospitalization in the 12 months before SLF initiation and during SLF use were compared.RESULTS In total, 17 COPD patients were given SLF during the study period. The mean FEV1 was 0.51 L (21% predicted). All participants reported MRC5/5 dyspnea and were prescribed regular low-dose oral morphine for daily breathlessness prior to SLF initiation. Most patients used SLF for more than 6 months, and 76.5% of the study group found intermediate or major improvement in breathlessness episodes. There was no significant change in the rates of exacerbation and admission for acute respiratory failure while on SLF.CONCLUSION In this review, we report real-life, long-term data on severe COPD patients using self-controlled as-needed SLF, showing patient acceptability, an improvement in dyspnea, and limited side effects. Hence, this represents an important step toward the first effective alternative rescue medication for the relief of breakthrough dyspnea since short-acting inhalers. Further study using a randomized trial design is required to confirm the efficacy of this therapy." @default.
• W4384698677 created "2023-07-20" @default.
• W4384698677 creator A5002017949 @default.
• W4384698677 creator A5010235018 @default.
• W4384698677 creator A5026394873 @default.
• W4384698677 creator A5035154397 @default.
• W4384698677 creator A5059989833 @default.
• W4384698677 creator A5064824911 @default.
• W4384698677 creator A5088801073 @default.
• W4384698677 date "2023-06-07" @default.
• W4384698677 modified "2023-10-04" @default.
• W4384698677 title "Sublingual fentanyl for refractory episodic acute dyspnea in patients with advanced chronic obstructive pulmonary disease (COPD): A real-world study" @default.
• W4384698677 cites W1965764655 @default.
• W4384698677 cites W1999413617 @default.
• W4384698677 cites W2022829670 @default.
• W4384698677 cites W2059944626 @default.
• W4384698677 cites W2089663760 @default.
• W4384698677 cites W2146250410 @default.
• W4384698677 cites W2405578958 @default.
• W4384698677 cites W2552274843 @default.
• W4384698677 cites W2587354159 @default.
• W4384698677 cites W2599390132 @default.
• W4384698677 cites W2607275024 @default.
• W4384698677 cites W2619856298 @default.
• W4384698677 cites W2743251337 @default.
• W4384698677 cites W2954372762 @default.
• W4384698677 cites W3016201212 @default.
• W4384698677 cites W3103216850 @default.
• W4384698677 doi "https://doi.org/10.1080/24745332.2023.2224109" @default.
• W4384698677 hasPublicationYear "2023" @default.
• W4384698677 type Work @default.
• W4384698677 citedByCount "1" @default.
• W4384698677 crossrefType "journal-article" @default.
• W4384698677 hasAuthorship W4384698677A5002017949 @default.
• W4384698677 hasAuthorship W4384698677A5010235018 @default.
• W4384698677 hasAuthorship W4384698677A5026394873 @default.
• W4384698677 hasAuthorship W4384698677A5035154397 @default.
• W4384698677 hasAuthorship W4384698677A5059989833 @default.
• W4384698677 hasAuthorship W4384698677A5064824911 @default.
• W4384698677 hasAuthorship W4384698677A5088801073 @default.
• W4384698677 hasConcept C126322002 @default.
• W4384698677 hasConcept C167135981 @default.
• W4384698677 hasConcept C1862650 @default.
• W4384698677 hasConcept C194828623 @default.
• W4384698677 hasConcept C197934379 @default.
• W4384698677 hasConcept C2776780178 @default.
• W4384698677 hasConcept C2777014857 @default.
• W4384698677 hasConcept C71924100 @default.
• W4384698677 hasConceptScore W4384698677C126322002 @default.
• W4384698677 hasConceptScore W4384698677C167135981 @default.
• W4384698677 hasConceptScore W4384698677C1862650 @default.
• W4384698677 hasConceptScore W4384698677C194828623 @default.
• W4384698677 hasConceptScore W4384698677C197934379 @default.
• W4384698677 hasConceptScore W4384698677C2776780178 @default.
• W4384698677 hasConceptScore W4384698677C2777014857 @default.
• W4384698677 hasConceptScore W4384698677C71924100 @default.
• W4384698677 hasIssue "3" @default.
• W4384698677 hasLocation W43846986771 @default.
• W4384698677 hasOpenAccess W4384698677 @default.
• W4384698677 hasPrimaryLocation W43846986771 @default.
• W4384698677 hasRelatedWork W2165653930 @default.
• W4384698677 hasRelatedWork W2168449172 @default.
• W4384698677 hasRelatedWork W2413531698 @default.
• W4384698677 hasRelatedWork W2518136641 @default.
• W4384698677 hasRelatedWork W2759187465 @default.
• W4384698677 hasRelatedWork W3095549380 @default.
• W4384698677 hasRelatedWork W3175747749 @default.
• W4384698677 hasRelatedWork W3177022460 @default.
• W4384698677 hasRelatedWork W3202380206 @default.
• W4384698677 hasRelatedWork W2151395709 @default.
• W4384698677 hasVolume "7" @default.
• W4384698677 isParatext "false" @default.
• W4384698677 isRetracted "false" @default.
• W4384698677 workType "article" @default.