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- W4384700543 abstract "Abnormal immune responses to the resident gut microbiome can drive inflammatory bowel disease (IBD). Here, we combine high-resolution, culture-based shotgun metagenomic sequencing and analysis with matched host transcriptomics across three intestinal sites (terminal ileum, cecum, rectum) from pediatric IBD (PIBD) patients (n = 58) and matched controls (n = 42) to investigate this relationship. Combining our site-specific approach with bacterial culturing, we establish a cohort-specific bacterial culture collection, comprising 6,620 isolates (170 distinct species, 32 putative novel), cultured from 286 mucosal biopsies. Phylogeny-based, clade-specific metagenomic analysis identifies key, functionally distinct Enterococcus clades associated with either IBD or health. Strain-specific in vitro validation demonstrates differences in cell cytotoxicity and inflammatory signaling in intestinal epithelial cells, consistent with the colonic mucosa-specific response measured in patients with IBD. This demonstrates the importance of strain-specific phenotypes and consideration of anatomical sites in exploring the dysregulated host-bacterial interactions in IBD." @default.
- W4384700543 created "2023-07-20" @default.
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- W4384700543 date "2023-07-01" @default.
- W4384700543 modified "2023-09-27" @default.
- W4384700543 title "Bacterial clade-specific analysis identifies distinct epithelial responses in inflammatory bowel disease" @default.
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- W4384700543 doi "https://doi.org/10.1016/j.xcrm.2023.101124" @default.
- W4384700543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37467722" @default.
- W4384700543 hasPublicationYear "2023" @default.
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