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• W4384700785 abstract "The use of broadly neutralizing antibodies (bNAbs) as a cure-related research strategy for human immunodeficiency virus (HIV) has gained attention from the scientific community. bNAbs are specialized antibodies that target HIV by binding to proteins on the surface of the virus, preventing the infection of human cells. In HIV clinical studies assessing the use of bNAbs, it has been common practice to prescreen potential participants for bNAb sensitivity. However, the use of prescreening in HIV bNAb clinical trials is a topic of ongoing debate, with regard to its potential benefits and limitations. In this paper, we examine the possible benefits and limitations of prescreening for bNAb sensitivity in HIV cure-related studies, and suggest alternative methods which may be more effective or efficient at saving costs and time. Ultimately, the decision to use prescreening in HIV bNAb clinical trials should be based on a careful assessment of the potential benefits and limitations of this approach, as well as the specific needs, goals, design, and population of the study in question." @default.
• W4384700785 created "2023-07-20" @default.
• W4384700785 creator A5028152156 @default.
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• W4384700785 date "2023-09-01" @default.
• W4384700785 modified "2023-10-18" @default.
• W4384700785 title "To prescreen or not to prescreen for broadly neutralizing antibody sensitivity in HIV cure-related trials" @default.
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• W4384700785 doi "https://doi.org/10.1016/j.jve.2023.100339" @default.
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