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- W4384700910 abstract "Hunner-type interstitial cystitis (HIC) is a rare, chronic inflammatory disease of the urinary bladder with unknown etiology and genetic background. Here, we conduct a genome-wide association study of 144 patients with HIC and 41,516 controls of Japanese ancestry. The genetic variant, rs1794275, in the major histocompatibility complex (MHC) region (chromosome 6p21.3) is associated with HIC risk (odds ratio [OR] = 2.32; p = 3.4 × 10-9). The association is confirmed in a replication set of 26 cases and 1,026 controls (p = 0.014). Fine mapping demonstrates the contribution to the disease risk of a completely linked haplotype of three human leukocyte antigen HLA-DQβ1 amino acid positions, 71, 74, and 75 (OR = 1.94; p = 5 × 10-8) and of HLA-DPβ1 amino acid position 178, which tags HLA-DPB1∗04:02 (OR = 2.35; p = 7.5 × 10-8). The three HLA-DQβ1 amino acid positions are located together at the peptide binding groove, suggesting their functional importance in antigen presentation. Our study reveals genetic contributions to HIC risk that may be associated with class II MHC molecule antigen presentation." @default.
- W4384700910 created "2023-07-20" @default.
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- W4384700910 date "2023-07-01" @default.
- W4384700910 modified "2023-10-17" @default.
- W4384700910 title "Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis" @default.
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- W4384700910 cites W1976027219 @default.
- W4384700910 cites W1981189656 @default.
- W4384700910 cites W1992616650 @default.
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- W4384700910 cites W2016941468 @default.
- W4384700910 cites W2026937220 @default.
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- W4384700910 cites W2088315735 @default.
- W4384700910 cites W2119900188 @default.
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- W4384700910 cites W2467624056 @default.
- W4384700910 cites W2510973425 @default.
- W4384700910 cites W2586504828 @default.
- W4384700910 cites W2587257410 @default.
- W4384700910 cites W2605187976 @default.
- W4384700910 cites W2605402870 @default.
- W4384700910 cites W2610856078 @default.
- W4384700910 cites W2729374181 @default.
- W4384700910 cites W2763431642 @default.
- W4384700910 cites W2802442746 @default.
- W4384700910 cites W2803458969 @default.
- W4384700910 cites W2886159565 @default.
- W4384700910 cites W2891233663 @default.
- W4384700910 cites W2913411807 @default.
- W4384700910 cites W2921956301 @default.
- W4384700910 cites W2936898442 @default.
- W4384700910 cites W2950099124 @default.
- W4384700910 cites W2952780392 @default.
- W4384700910 cites W2957318859 @default.
- W4384700910 cites W2966402854 @default.
- W4384700910 cites W2975095072 @default.
- W4384700910 cites W2981477552 @default.
- W4384700910 cites W2990059271 @default.
- W4384700910 cites W3000261545 @default.
- W4384700910 cites W3007238547 @default.
- W4384700910 cites W3014056694 @default.
- W4384700910 cites W3014604613 @default.
- W4384700910 cites W3015493096 @default.
- W4384700910 cites W3080980001 @default.