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- W4384700963 endingPage "114302" @default.
- W4384700963 startingPage "114302" @default.
- W4384700963 abstract "This study aimed to investigate the impact and mechanism of gut microbiota on the enhancement of cognitive function in methamphetamine (MA)-dependent individuals during aerobic exercise training. A total of sixty-four MA-dependent individuals were randomly assigned to either an aerobic exercise training group (DK, n = 32) or a conventional rehabilitation group (CK, n = 32). After an eight-week intervention, the participants' working memory and inhibition ability were assessed using the Stroop paradigm and Go/NoGo paradigm, respectively. Gut microbiota composition was analyzed using high-throughput sequencing. 1) Eight weeks of aerobic exercise training significantly improved the working memory and inhibition ability of MA-dependent individuals (P < 0.05). 2) Following the intervention, the DK group exhibited significantly higher levels of Lactobacillus, Lactococcus lactis, Prevotellaceae, and Ruminococcaceae compared to the CK group. Conversely, the DK group demonstrated significantly lower levels of Desulfovibrio and Akkermansia compared to the CK group. Furthermore, the DK group showed significantly increased metabolic pathways associated with d-Glutaralate and d-Galactate Degradation, as well as the Alanine, aspartate, and glutamate metabolism pathway, compared to the control group. 3) Cognitive function related to MA addiction positively correlated with Bifidobacterium, Dialister, and Adlercreutzia, while negatively correlated with Enterobacteria, Bacillus cereus, Catabacter, and Akkermansia. Aerobic exercise training enhances working memory and inhibition ability in MA-dependent individuals, thereby mitigating the detrimental effects of MA addiction on cognitive function. Additionally, analysis of gut microbiota suggests that the modulation of gut microbiota and associated metabolic pathways play a role in regulating the improvement of cognitive function in MA-dependent individuals through exercise." @default.
- W4384700963 created "2023-07-20" @default.
- W4384700963 creator A5016050559 @default.
- W4384700963 creator A5082245617 @default.
- W4384700963 creator A5087796756 @default.
- W4384700963 date "2023-10-01" @default.
- W4384700963 modified "2023-10-16" @default.
- W4384700963 title "The impact of aerobic exercise training on cognitive function and gut microbiota in methamphetamine-dependent individuals in the community" @default.
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- W4384700963 doi "https://doi.org/10.1016/j.physbeh.2023.114302" @default.
- W4384700963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37474085" @default.
- W4384700963 hasPublicationYear "2023" @default.
- W4384700963 type Work @default.