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• W4384701765 endingPage "125885" @default.
• W4384701765 startingPage "125885" @default.
• W4384701765 abstract "DR0041 ORF encodes an uncharacterized Deinococcus lineage protein. We earlier reported presence of DR0041 protein in DNA repair complexes of Ssb and RecA in Deinococcus radiodurans. Here, we systematically examined the role of DR0041 in DNA metabolism using various experimental methodologies including electrophoretic mobility assays, nuclease assays, strand exchange assays and transmission electron microscopy. Interaction between DR0041 and the C-terminal acidic tail of Ssb was assessed through co-expression and in vivo cross-linking studies. A knockout mutant was constructed to understand importance of DR0041 ORF for various physiological processes. Results highlight binding of DR0041 protein to single-stranded and double-stranded DNA, interaction with Ssb-coated single-stranded DNA without interference with RecA-mediated strand exchange, protection of DNA from exonucleases, and compaction of high molecular weight DNA molecules into tightly condensed forms. Bridging and compaction of sheared DNA by DR0041 protein might have implications in the preservation of damaged DNA templates to maintain genome integrity upon exposure to gamma irradiation. Our results suggest that DR0041 protein is dispensable for growth under standard growth conditions and following gamma irradiation but contributes to protection of DNA during transformation. We discuss the role of DR0041 protein from the perspective of protection of broken DNA templates and functional redundancy." @default.
• W4384701765 created "2023-07-20" @default.
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• W4384701765 date "2023-09-01" @default.
• W4384701765 modified "2023-09-23" @default.
• W4384701765 title "Deinococcus lineage and Rad52 family-related protein DR0041 is involved in DNA protection and compaction" @default.
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• W4384701765 doi "https://doi.org/10.1016/j.ijbiomac.2023.125885" @default.
• W4384701765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37473881" @default.
• W4384701765 hasPublicationYear "2023" @default.
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