FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384704908> ?p ?o ?g. }

• W4384704908 endingPage "1377" @default.
• W4384704908 startingPage "1366" @default.
• W4384704908 abstract "Abstract Objectives To illustrate the metabolic regulatory mechanisms of Jiangzhi decoction (JZD) against non-alcoholic fatty liver disease (NAFLD). Methods High-fat diet (HFD)-induced NAFLD rats were treated with JZD. The pathological morphology, lipid indexes and liver function were detected. Metabolic profiles were examined by liquid chromatography–mass spectrometry (LC–MS). Multivariate and univariate statistical analysis were used to search the differential metabolites. Pathway enrichment analysis was carried out using Kyoto Encyclopedia of Genes and Genomes database. Compound-gene networks were built by Cytoscape software. Results JZD significantly alleviated the pathological conditions and improved lipid index levels. Multivariate analysis showed a good separation among different groups. Three hundred and twenty-seven metabolites in HFD versus control and 301 metabolites in JZD versus HFD were identified to be significantly different. Pathway enrichment analysis showed that lipid metabolism pathways were prominent altered pathways. Importantly, the relationships were more distant between JZD and HFD groups in all five lipid metabolism pathways, including arachidonic acid metabolism, linoleic acid metabolism, biosynthesis of unsaturated fatty acids, glycerophospholipid metabolism and sphingolipid metabolism, while those were obviously closer between JZD and control groups. Simultaneously, JZD treatment restored the levels of disturbed differential metabolites in HFD group. Conclusion JZD had an effect on alleviating NAFLD via regulating relevant lipid metabolism." @default.
• W4384704908 created "2023-07-20" @default.
• W4384704908 creator A5000534509 @default.
• W4384704908 creator A5028098177 @default.
• W4384704908 creator A5043528070 @default.
• W4384704908 creator A5049388814 @default.
• W4384704908 creator A5054565575 @default.
• W4384704908 creator A5073216396 @default.
• W4384704908 creator A5085982715 @default.
• W4384704908 date "2023-07-19" @default.
• W4384704908 modified "2023-10-15" @default.
• W4384704908 title "Metabolomic analysis identifies the regulation of lipid metabolism pathway as potential mechanisms of Jiangzhi decoction against non-alcoholic fatty liver disease" @default.
• W4384704908 cites W2897779004 @default.
• W4384704908 cites W4288010199 @default.
• W4384704908 cites W4308740989 @default.
• W4384704908 doi "https://doi.org/10.1093/jpp/rgad067" @default.
• W4384704908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37467485" @default.
• W4384704908 hasPublicationYear "2023" @default.
• W4384704908 type Work @default.
• W4384704908 citedByCount "1" @default.
• W4384704908 countsByYear W43847049082023 @default.
• W4384704908 crossrefType "journal-article" @default.
• W4384704908 hasAuthorship W4384704908A5000534509 @default.
• W4384704908 hasAuthorship W4384704908A5028098177 @default.
• W4384704908 hasAuthorship W4384704908A5043528070 @default.
• W4384704908 hasAuthorship W4384704908A5049388814 @default.
• W4384704908 hasAuthorship W4384704908A5054565575 @default.
• W4384704908 hasAuthorship W4384704908A5073216396 @default.
• W4384704908 hasAuthorship W4384704908A5085982715 @default.
• W4384704908 hasConcept C104317684 @default.
• W4384704908 hasConcept C126322002 @default.
• W4384704908 hasConcept C150194340 @default.
• W4384704908 hasConcept C152724338 @default.
• W4384704908 hasConcept C162317418 @default.
• W4384704908 hasConcept C181199279 @default.
• W4384704908 hasConcept C185592680 @default.
• W4384704908 hasConcept C190409667 @default.
• W4384704908 hasConcept C192989942 @default.
• W4384704908 hasConcept C21565614 @default.
• W4384704908 hasConcept C2776952329 @default.
• W4384704908 hasConcept C2776991927 @default.
• W4384704908 hasConcept C2778078955 @default.
• W4384704908 hasConcept C2778772119 @default.
• W4384704908 hasConcept C2778918659 @default.
• W4384704908 hasConcept C2779134260 @default.
• W4384704908 hasConcept C41625074 @default.
• W4384704908 hasConcept C4733338 @default.
• W4384704908 hasConcept C543025807 @default.
• W4384704908 hasConcept C55493867 @default.
• W4384704908 hasConcept C58017582 @default.
• W4384704908 hasConcept C60644358 @default.
• W4384704908 hasConcept C61705674 @default.
• W4384704908 hasConcept C62231903 @default.
• W4384704908 hasConcept C71924100 @default.
• W4384704908 hasConcept C86803240 @default.
• W4384704908 hasConcept C98274493 @default.
• W4384704908 hasConceptScore W4384704908C104317684 @default.
• W4384704908 hasConceptScore W4384704908C126322002 @default.
• W4384704908 hasConceptScore W4384704908C150194340 @default.
• W4384704908 hasConceptScore W4384704908C152724338 @default.
• W4384704908 hasConceptScore W4384704908C162317418 @default.
• W4384704908 hasConceptScore W4384704908C181199279 @default.
• W4384704908 hasConceptScore W4384704908C185592680 @default.
• W4384704908 hasConceptScore W4384704908C190409667 @default.
• W4384704908 hasConceptScore W4384704908C192989942 @default.
• W4384704908 hasConceptScore W4384704908C21565614 @default.
• W4384704908 hasConceptScore W4384704908C2776952329 @default.
• W4384704908 hasConceptScore W4384704908C2776991927 @default.
• W4384704908 hasConceptScore W4384704908C2778078955 @default.
• W4384704908 hasConceptScore W4384704908C2778772119 @default.
• W4384704908 hasConceptScore W4384704908C2778918659 @default.
• W4384704908 hasConceptScore W4384704908C2779134260 @default.
• W4384704908 hasConceptScore W4384704908C41625074 @default.
• W4384704908 hasConceptScore W4384704908C4733338 @default.
• W4384704908 hasConceptScore W4384704908C543025807 @default.
• W4384704908 hasConceptScore W4384704908C55493867 @default.
• W4384704908 hasConceptScore W4384704908C58017582 @default.
• W4384704908 hasConceptScore W4384704908C60644358 @default.
• W4384704908 hasConceptScore W4384704908C61705674 @default.
• W4384704908 hasConceptScore W4384704908C62231903 @default.
• W4384704908 hasConceptScore W4384704908C71924100 @default.
• W4384704908 hasConceptScore W4384704908C86803240 @default.
• W4384704908 hasConceptScore W4384704908C98274493 @default.
• W4384704908 hasFunder F4320317789 @default.
• W4384704908 hasFunder F4320321001 @default.
• W4384704908 hasIssue "10" @default.
• W4384704908 hasLocation W43847049081 @default.
• W4384704908 hasLocation W43847049082 @default.
• W4384704908 hasOpenAccess W4384704908 @default.
• W4384704908 hasPrimaryLocation W43847049081 @default.
• W4384704908 hasRelatedWork W1869542021 @default.
• W4384704908 hasRelatedWork W2223372642 @default.
• W4384704908 hasRelatedWork W2601987466 @default.
• W4384704908 hasRelatedWork W3002410440 @default.
• W4384704908 hasRelatedWork W3094170127 @default.
• W4384704908 hasRelatedWork W3132116617 @default.
• W4384704908 hasRelatedWork W3164327727 @default.
• W4384704908 hasRelatedWork W4200460456 @default.

• next