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- W4384784524 abstract "Resistance to presently available antifungals and their toxicities is a serious concern throughout the world. It is necessary to investigate innovative, more effective molecules especially derived from medicinally active plants with lesser side effects. Allyl methyl sulfide (AMS), an organosulfur derived from garlic oil, was explored for its activity against Candida albicans strains. The minimum Inhibitory Concentration (MIC) values of AMS were found to be 200 µg/mL and 250 µg/mL, and the Minimum Fungicidal Concentration (MFC) values of AMS were 400 µg/mL and 500 µg/mL for the selected strains, respectively. Fungal growth in C. albicans was 90% inhibited at their respective MIC values, as demonstrated by micro broth dilution experiments. After treatment with AMS, C. albicans’ release of extracellular proteinases, phospholipases, and biofilm formation was significantly inhibited. In C. albicans, AMS treatment also reduces attachment to buccal epithelial tissues as measured microscopically. In addition, AMS exhibited significant control over yeast to hypha transitions in C. albicans cells, which constitutes one of the major virulent features of the Candida species. All the findings of this study indicate that AMS may be a potential alternative to commonly used antifungals." @default.
- W4384784524 created "2023-07-20" @default.
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- W4384784524 date "2023-03-01" @default.
- W4384784524 modified "2023-09-26" @default.
- W4384784524 title "Signature Garlic Phytochemical as a Potential Anti-Candidal Candidate Targeting Virulence Factors in Candida albicans " @default.
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- W4384784524 doi "https://doi.org/10.3390/ecb2023-14080" @default.
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