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- W4384789944 abstract "In this work a nonlinear mechanistic model was developed predicting the product formation of recombinant lactate dehydrogenase (LDH) using fed-batch cultivations of Escherichia coli. The derived product formation kinetics consider the inclusion body (IB) fraction as well as the soluble protein fraction. After the structural identifiability of the model parameters was analyzed, five fed-batch cultivations were conducted in total in order to identify the model parameters and to validate the model subsequently. The accuracy of the final model was overall good with NRMSE values of around 0.1 to 0.2 for both product fractions. The derived model can be seen as an enabler for advanced monitoring and control strategies like model predictive control and other advances technologies defined in the process analytical technology (PAT) initiative." @default.
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- W4384789944 date "2023-01-01" @default.
- W4384789944 modified "2023-09-25" @default.
- W4384789944 title "Mechanistic modeling of product formation in recombinant Escherichia coli cultivations" @default.
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- W4384789944 doi "https://doi.org/10.1016/b978-0-443-15274-0.50078-0" @default.
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