Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384817844> ?p ?o ?g. }
- W4384817844 abstract "PIWI-interacting RNA (piRNA) pathways control transposable elements (TEs) and endogenous genes, playing important roles in animal gamete formation. However, the underlying piRNA biogenesis mechanisms remain elusive. Here, we show that endogenous protein coding sequences (CDSs), which are normally used for translation, serve as origins of noncoding piRNA biogenesis in Drosophila melanogaster testes. The product, namely, CDS-piRNAs, formed silencing complexes with Aubergine (Aub) in germ cells. Proximity proteome and functional analyses show that CDS-piRNAs and cluster/TE-piRNAs are distinct species occupying Aub, the former loading selectively relies on chaperone Cyclophilin 40. Moreover, Argonaute 2 (Ago2) and Dicer-2 activities were found critical for CDS-piRNA production. We provide evidence that Ago2-bound short interfering RNAs (siRNAs) and microRNAs (miRNAs) specify precursors to be processed into piRNAs. We further demonstrate that Aub is crucial in spermatid differentiation, regulating chromatins through mRNA cleavage. Collectively, our data illustrate a unique strategy used by male germ line, expanding piRNA repertoire for silencing of endogenous genes during spermatogenesis." @default.
- W4384817844 created "2023-07-21" @default.
- W4384817844 creator A5019506631 @default.
- W4384817844 creator A5034615228 @default.
- W4384817844 creator A5056410844 @default.
- W4384817844 date "2023-07-21" @default.
- W4384817844 modified "2023-09-25" @default.
- W4384817844 title "miRNA/siRNA-directed pathway to produce noncoding piRNAs from endogenous protein-coding regions ensures <i>Drosophila</i> spermatogenesis" @default.
- W4384817844 cites W1596971406 @default.
- W4384817844 cites W1659482056 @default.
- W4384817844 cites W1709210465 @default.
- W4384817844 cites W1773519674 @default.
- W4384817844 cites W1823358129 @default.
- W4384817844 cites W1928238200 @default.
- W4384817844 cites W1952594807 @default.
- W4384817844 cites W1966894142 @default.
- W4384817844 cites W1973199417 @default.
- W4384817844 cites W1976342457 @default.
- W4384817844 cites W1977733607 @default.
- W4384817844 cites W1980244456 @default.
- W4384817844 cites W1990654003 @default.
- W4384817844 cites W1999901063 @default.
- W4384817844 cites W2015402753 @default.
- W4384817844 cites W2019806092 @default.
- W4384817844 cites W2026584449 @default.
- W4384817844 cites W2032605950 @default.
- W4384817844 cites W2033518550 @default.
- W4384817844 cites W2034255392 @default.
- W4384817844 cites W2035424802 @default.
- W4384817844 cites W2040323170 @default.
- W4384817844 cites W2044545834 @default.
- W4384817844 cites W2045214060 @default.
- W4384817844 cites W2045437345 @default.
- W4384817844 cites W2067365193 @default.
- W4384817844 cites W2069799979 @default.
- W4384817844 cites W2071617636 @default.
- W4384817844 cites W2072795057 @default.
- W4384817844 cites W2077050148 @default.
- W4384817844 cites W2077878547 @default.
- W4384817844 cites W2078105351 @default.
- W4384817844 cites W2089971639 @default.
- W4384817844 cites W2103336074 @default.
- W4384817844 cites W2105707485 @default.
- W4384817844 cites W2127627617 @default.
- W4384817844 cites W2132989501 @default.
- W4384817844 cites W2136020785 @default.
- W4384817844 cites W2137073470 @default.
- W4384817844 cites W2141254120 @default.
- W4384817844 cites W2141548533 @default.
- W4384817844 cites W2146339022 @default.
- W4384817844 cites W2153601587 @default.
- W4384817844 cites W2157378797 @default.
- W4384817844 cites W2161682404 @default.
- W4384817844 cites W2273847944 @default.
- W4384817844 cites W2283725187 @default.
- W4384817844 cites W2402374450 @default.
- W4384817844 cites W2553553029 @default.
- W4384817844 cites W2606824156 @default.
- W4384817844 cites W2804978909 @default.
- W4384817844 cites W2888618670 @default.
- W4384817844 cites W2890279486 @default.
- W4384817844 cites W2901318957 @default.
- W4384817844 cites W2903232440 @default.
- W4384817844 cites W2916031961 @default.
- W4384817844 cites W2943513597 @default.
- W4384817844 cites W2943992342 @default.
- W4384817844 cites W2947463429 @default.
- W4384817844 cites W2949166031 @default.
- W4384817844 cites W2950516947 @default.
- W4384817844 cites W2967128888 @default.
- W4384817844 cites W2968255719 @default.
- W4384817844 cites W2995253087 @default.
- W4384817844 cites W3037082378 @default.
- W4384817844 cites W3056583907 @default.
- W4384817844 cites W3087026888 @default.
- W4384817844 cites W3100263847 @default.
- W4384817844 cites W3116495870 @default.
- W4384817844 cites W3124738984 @default.
- W4384817844 cites W3145743996 @default.
- W4384817844 cites W3160787014 @default.
- W4384817844 cites W3163830965 @default.
- W4384817844 cites W3184258984 @default.
- W4384817844 cites W3191485155 @default.
- W4384817844 cites W3193439546 @default.
- W4384817844 cites W3196648942 @default.
- W4384817844 cites W4200304551 @default.
- W4384817844 cites W4221048359 @default.
- W4384817844 cites W4285031811 @default.
- W4384817844 doi "https://doi.org/10.1126/sciadv.adh0397" @default.
- W4384817844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37467338" @default.
- W4384817844 hasPublicationYear "2023" @default.
- W4384817844 type Work @default.
- W4384817844 citedByCount "0" @default.
- W4384817844 crossrefType "journal-article" @default.
- W4384817844 hasAuthorship W4384817844A5019506631 @default.
- W4384817844 hasAuthorship W4384817844A5034615228 @default.
- W4384817844 hasAuthorship W4384817844A5056410844 @default.
- W4384817844 hasBestOaLocation W43848178441 @default.
- W4384817844 hasConcept C104317684 @default.
- W4384817844 hasConcept C119056186 @default.