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- W4384818448 abstract "Background The hippocampus is a clinically relevant region where neurogenesis and neuroplasticity occur throughout the whole lifespan. Neuroinflammation and cardiorespiratory fitness (CRF) may influence hippocampal integrity by modulating the processes promoting neurogenesis and neuroprotection that contribute to the preservation of functions. This study aimed to investigate the effects of neuroinflammation and CRF on hippocampal volume in multiple sclerosis (MS) patients with relapsing-remitting (RR) and progressive (P) clinical phenotypes. The influence of neuroinflammation and CRF on brain, grey matter (GM) and thalamic volumes was also assessed to determine whether the effects were specific for the hippocampus. Method Brain 3T structural MRI scans and maximum oxygen consumption (VO 2 max), a proxy of CRF, were acquired from 81 MS patients (27 RR and 54 P) and 45 age-matched and sex-matched healthy controls. T2-hyperintense white matter lesion volume (T2-LV) and choroid plexuses volume (CPV) were quantified as neuroinflammatory measures. Associations of demographic, clinical, neuroinflammatory and CRF measures with normalised brain, GM, hippocampal and thalamic volumes in relapsing-remitting MS (RRMS) and progressive MS patients were assessed using Shapley and best subset selection regression. Results For most volumetric measures, the largest portions of variance were explained by T2-LV (variable importance (VI)=9.4–39.4) and CPV (VI=4.5–26.2). VO 2 max explained the largest portion of variance of normalised hippocampal volume only in RRMS patients (VI=16.9) and was retained as relevant predictor (standardised β=0.374, p=0.023) with T2-LV (standardised β=−0.330, p=0.016). Conclusions A higher CRF may play a specific neuroprotective role on MS patients’ hippocampal integrity, but only in the RR phase of the disease." @default.
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- W4384818448 date "2023-07-19" @default.
- W4384818448 modified "2023-09-24" @default.
- W4384818448 title "Influence of cardiorespiratory fitness and MRI measures of neuroinflammation on hippocampal volume in multiple sclerosis" @default.
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- W4384818448 doi "https://doi.org/10.1136/jnnp-2023-331482" @default.
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