Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384818697> ?p ?o ?g. }
- W4384818697 endingPage "2852" @default.
- W4384818697 startingPage "2837" @default.
- W4384818697 abstract "LAMP2 (lysosomal associated membrane protein 2) is one of the major protein components of the lysosomal membrane. There currently exist three LAMP2 isoforms, LAMP2A, LAMP2B and LAMP2C, and they vary in distribution and function. LAMP2A serves as a receptor and channel for transporting cytosolic proteins in a process called chaperone-mediated autophagy (CMA). LAMP2B is required for autophagosome-lysosome fusion in cardiomyocytes and is one of the components of exosome membranes. LAMP2C is primarily implicated in a novel type of autophagy in which nucleic acids are taken up into lysosomes for degradation. In this review, the current evidence for the function of each LAMP2 isoform in various pathophysiological processes and human diseases, as well as their possible mechanisms, are comprehensively summarized. We discuss the evolutionary patterns of the three isoforms in vertebrates and provide technical guidance on investigating these isoforms. We are also concerned with the newly arising questions in this particular research area that remain unanswered. Advances in the functions of the three LAMP2 isoforms will uncover new links between lysosomal dysfunction, autophagy and human diseases.Abbreviation: ACSL4: acyl-CoA synthetase long-chain family member 4; AD: Alzheimer disease; Ag: antigens; APP: amyloid beta precursor protein; ATG14: autophagy related 14; AVSF: autophagic vacuoles with unique sarcolemmal features; BBC3/PUMA: BCL2 binding component 3; CCD: C-terminal coiled coil domain; CMA: chaperone-mediated autophagy; CVDs: cardiovascular diseases; DDIT4/REDD1: DNA damage inducible transcript 4; ECs: endothelial cells; ER: endoplasmic reticulum; ESCs: embryonic stem cells; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GBA/β-glucocerebrosidase: glucosylceramidase beta; GSCs: glioblastoma stem cells; HCC: hepatocellular carcinoma; HD: Huntington disease; HSCs: hematopoietic stem cells; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; IL3: interleukin 3; IR: ischemia-reperfusion; LAMP2: lysosomal associated membrane protein 2; LDs: lipid droplets; LRRK2: leucine rich repeat kinase 2; MA: macroautophagy; MHC: major histocompatibility complex; MST1: macrophage stimulating 1; NAFLD: nonalcoholic fatty liver disease; NFE2L2/NRF2: NFE2 like bZIP transcription factor 2; NLRP3: NLR family pyrin domain containing 3; PARK7: Parkinsonism associated deglycase; PD: Parkinson disease; PEA15/PED: proliferation and apoptosis adaptor protein 15; PKM/PKM2: pyruvate kinase M1/2; RA: rheumatoid arthritis; RARA: retinoic acid receptor alpha; RCAN1: regulator of calcineurin 1; RCC: renal cell carcinoma; RDA: RNautophagy and DNautophagy; RNAi: RNA interference; RND3: Rho Family GTPase 3; SG-NOS3/eNOS: deleterious glutathionylated NOS3; SLE: systemic lupus erythematosus; TAMs: tumor-associated macrophages; TME: tumor microenvironment; UCHL1: ubiquitin C-terminal hydrolase L1; VAMP8: vesicle associated membrane protein 8." @default.
- W4384818697 created "2023-07-21" @default.
- W4384818697 creator A5006191181 @default.
- W4384818697 creator A5041230019 @default.
- W4384818697 creator A5049895313 @default.
- W4384818697 creator A5062707884 @default.
- W4384818697 creator A5072800463 @default.
- W4384818697 creator A5074140059 @default.
- W4384818697 creator A5075596275 @default.
- W4384818697 creator A5076206900 @default.
- W4384818697 creator A5082405801 @default.
- W4384818697 date "2023-07-21" @default.
- W4384818697 modified "2023-10-11" @default.
- W4384818697 title "LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles" @default.
- W4384818697 cites W1507640463 @default.
- W4384818697 cites W1521169671 @default.
- W4384818697 cites W1550126302 @default.
- W4384818697 cites W1643149493 @default.
- W4384818697 cites W1664365918 @default.
- W4384818697 cites W1706150252 @default.
- W4384818697 cites W1889146348 @default.
- W4384818697 cites W1965781173 @default.
- W4384818697 cites W1966233516 @default.
- W4384818697 cites W1966347583 @default.
- W4384818697 cites W1966881634 @default.
- W4384818697 cites W1968322176 @default.
- W4384818697 cites W1968665833 @default.
- W4384818697 cites W1971023090 @default.
- W4384818697 cites W1971411291 @default.
- W4384818697 cites W1983947354 @default.
- W4384818697 cites W1990012982 @default.
- W4384818697 cites W1993931348 @default.
- W4384818697 cites W1994373739 @default.
- W4384818697 cites W2010538356 @default.
- W4384818697 cites W2013944211 @default.
- W4384818697 cites W2021919397 @default.
- W4384818697 cites W2022716167 @default.
- W4384818697 cites W2026531364 @default.
- W4384818697 cites W2027096397 @default.
- W4384818697 cites W2027797630 @default.
- W4384818697 cites W2031978571 @default.
- W4384818697 cites W2033612573 @default.
- W4384818697 cites W2036994468 @default.
- W4384818697 cites W2038049117 @default.
- W4384818697 cites W2038881512 @default.
- W4384818697 cites W2039357236 @default.
- W4384818697 cites W2041456356 @default.
- W4384818697 cites W2042840948 @default.
- W4384818697 cites W2043882563 @default.
- W4384818697 cites W2049613365 @default.
- W4384818697 cites W2051429808 @default.
- W4384818697 cites W2055039738 @default.
- W4384818697 cites W2062790216 @default.
- W4384818697 cites W2066234893 @default.
- W4384818697 cites W2068231534 @default.
- W4384818697 cites W2068288454 @default.
- W4384818697 cites W2074180938 @default.
- W4384818697 cites W2079123204 @default.
- W4384818697 cites W2081765214 @default.
- W4384818697 cites W2089551665 @default.
- W4384818697 cites W2093637710 @default.
- W4384818697 cites W2101962395 @default.
- W4384818697 cites W2104127214 @default.
- W4384818697 cites W2106565509 @default.
- W4384818697 cites W2109716633 @default.
- W4384818697 cites W2110676385 @default.
- W4384818697 cites W2117121951 @default.
- W4384818697 cites W2123720369 @default.
- W4384818697 cites W2124165909 @default.
- W4384818697 cites W2128407654 @default.
- W4384818697 cites W2130371399 @default.
- W4384818697 cites W2133962007 @default.
- W4384818697 cites W2134892601 @default.
- W4384818697 cites W2136032819 @default.
- W4384818697 cites W2136733611 @default.
- W4384818697 cites W2137771963 @default.
- W4384818697 cites W2140664473 @default.
- W4384818697 cites W2143070222 @default.
- W4384818697 cites W2146961420 @default.
- W4384818697 cites W2217838242 @default.
- W4384818697 cites W2272573169 @default.
- W4384818697 cites W2294910886 @default.
- W4384818697 cites W2567119859 @default.
- W4384818697 cites W2590970381 @default.
- W4384818697 cites W2604856698 @default.
- W4384818697 cites W2607139744 @default.
- W4384818697 cites W2762703026 @default.
- W4384818697 cites W2771489907 @default.
- W4384818697 cites W2795906582 @default.
- W4384818697 cites W2804540127 @default.
- W4384818697 cites W2809088149 @default.
- W4384818697 cites W2810312556 @default.
- W4384818697 cites W2882031129 @default.
- W4384818697 cites W2889307573 @default.
- W4384818697 cites W2890366947 @default.
- W4384818697 cites W2905996686 @default.
- W4384818697 cites W2911048719 @default.
- W4384818697 cites W2913938895 @default.