FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384819470> ?p ?o ?g. }

• W4384819470 endingPage "11253" @default.
• W4384819470 startingPage "11243" @default.
• W4384819470 abstract "Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) is a powerful analytical technique that provides spatially preserved detection and quantification of analytes in tissue specimens. However, clinical translation still requires improved throughput, precision, and accuracy. To accomplish this, we created Chemical QuantArray, a gelatin tissue microarray (TMA) mold filled with serial dilutions of isotopically labeled endogenous metabolite standards. The mold is then cryo-sectioned onto a tissue homogenate to produce calibration curves. To improve precision and accuracy, we automatically remove pixels outside of each TMA well and investigated several intensity normalizations, including the utilization of a second stable isotope internal standard (IS). Chemical QuantArray enables the quantification of several endogenous metabolites over a wide dynamic range and significantly improve over current approaches. The technique reduces the space needed on the MALDI slides for calibration standards by approximately 80%. Furthermore, removal of empty pixels and normalization to an internal standard or matrix peak provided precision (<20% RSD) and accuracy (<20% DEV). Finally, we demonstrate the applicability of Chemical QuantArray by quantifying multiple purine metabolites in 14 clinical tumor specimens using a single MALDI slide. Chemical QuantArray improves the analytical characteristics and practical feasibility of MALDI-MSI metabolite quantification in clinical and translational applications." @default.
• W4384819470 created "2023-07-21" @default.
• W4384819470 creator A5010234110 @default.
• W4384819470 creator A5034102438 @default.
• W4384819470 creator A5039683075 @default.
• W4384819470 creator A5047848562 @default.
• W4384819470 creator A5050679549 @default.
• W4384819470 creator A5054904433 @default.
• W4384819470 creator A5055282139 @default.
• W4384819470 creator A5061890301 @default.
• W4384819470 creator A5072335242 @default.
• W4384819470 creator A5075200875 @default.
• W4384819470 creator A5075621139 @default.
• W4384819470 creator A5078508725 @default.
• W4384819470 creator A5079882221 @default.
• W4384819470 creator A5092500072 @default.
• W4384819470 date "2023-07-20" @default.
• W4384819470 modified "2023-10-15" @default.
• W4384819470 title "Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging" @default.
• W4384819470 cites W1985407729 @default.
• W4384819470 cites W1988584379 @default.
• W4384819470 cites W2029744318 @default.
• W4384819470 cites W2033278243 @default.
• W4384819470 cites W2037347562 @default.
• W4384819470 cites W2042850156 @default.
• W4384819470 cites W2056959697 @default.
• W4384819470 cites W2075005181 @default.
• W4384819470 cites W2121668219 @default.
• W4384819470 cites W2140695271 @default.
• W4384819470 cites W2237957677 @default.
• W4384819470 cites W2273577024 @default.
• W4384819470 cites W2321813033 @default.
• W4384819470 cites W2560539177 @default.
• W4384819470 cites W2564082082 @default.
• W4384819470 cites W2597856736 @default.
• W4384819470 cites W2797470297 @default.
• W4384819470 cites W2915793957 @default.
• W4384819470 cites W2950983102 @default.
• W4384819470 cites W2955085129 @default.
• W4384819470 cites W2991547182 @default.
• W4384819470 cites W3007236030 @default.
• W4384819470 cites W3132533107 @default.
• W4384819470 cites W3136137010 @default.
• W4384819470 cites W3159468964 @default.
• W4384819470 cites W3163718364 @default.
• W4384819470 cites W3164568596 @default.
• W4384819470 cites W4200621939 @default.
• W4384819470 cites W4206712596 @default.
• W4384819470 cites W4220720568 @default.
• W4384819470 cites W4225162939 @default.
• W4384819470 cites W4225529913 @default.
• W4384819470 cites W4292183618 @default.
• W4384819470 cites W4292240378 @default.
• W4384819470 cites W4293173685 @default.
• W4384819470 cites W4296748909 @default.
• W4384819470 cites W4312211446 @default.
• W4384819470 doi "https://doi.org/10.1021/acs.analchem.3c00803" @default.
• W4384819470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37469028" @default.
• W4384819470 hasPublicationYear "2023" @default.
• W4384819470 type Work @default.
• W4384819470 citedByCount "0" @default.
• W4384819470 crossrefType "journal-article" @default.
• W4384819470 hasAuthorship W4384819470A5010234110 @default.
• W4384819470 hasAuthorship W4384819470A5034102438 @default.
• W4384819470 hasAuthorship W4384819470A5039683075 @default.
• W4384819470 hasAuthorship W4384819470A5047848562 @default.
• W4384819470 hasAuthorship W4384819470A5050679549 @default.
• W4384819470 hasAuthorship W4384819470A5054904433 @default.
• W4384819470 hasAuthorship W4384819470A5055282139 @default.
• W4384819470 hasAuthorship W4384819470A5061890301 @default.
• W4384819470 hasAuthorship W4384819470A5072335242 @default.
• W4384819470 hasAuthorship W4384819470A5075200875 @default.
• W4384819470 hasAuthorship W4384819470A5075621139 @default.
• W4384819470 hasAuthorship W4384819470A5078508725 @default.
• W4384819470 hasAuthorship W4384819470A5079882221 @default.
• W4384819470 hasAuthorship W4384819470A5092500072 @default.
• W4384819470 hasBestOaLocation W43848194702 @default.
• W4384819470 hasConcept C101092202 @default.
• W4384819470 hasConcept C10390740 @default.
• W4384819470 hasConcept C105795698 @default.
• W4384819470 hasConcept C113196181 @default.
• W4384819470 hasConcept C119128265 @default.
• W4384819470 hasConcept C136886441 @default.
• W4384819470 hasConcept C144024400 @default.
• W4384819470 hasConcept C150394285 @default.
• W4384819470 hasConcept C154945302 @default.
• W4384819470 hasConcept C159078339 @default.
• W4384819470 hasConcept C162356407 @default.
• W4384819470 hasConcept C162711632 @default.
• W4384819470 hasConcept C165838908 @default.
• W4384819470 hasConcept C178790620 @default.
• W4384819470 hasConcept C185592680 @default.
• W4384819470 hasConcept C186060115 @default.
• W4384819470 hasConcept C19165224 @default.
• W4384819470 hasConcept C21565614 @default.
• W4384819470 hasConcept C23531484 @default.
• W4384819470 hasConcept C24066741 @default.
• W4384819470 hasConcept C31972630 @default.

• next