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- W4384819931 abstract "Interleukin-6 (IL-6)-type cytokines not only have key immunomodulatory functions that affect the pathogenesis of diseases such as autoimmune diseases, chronic inflammatory conditions, and cancer, but also fulfill important homeostatic tasks. Even though the pro-inflammatory arm has hindered the development of therapeutics based on natural-like IL-6-type cytokines to date, current synthetic trends might pave the way to overcome these limitations and eventually lead to immune-inert designer cytokines to aid type 2 diabetes and brain injuries. Those synthetic biology approaches include mutations, fusion proteins, and inter-cytokine swapping, and resulted in IL-6-type cytokines with altered receptor affinities, extended target cell profiles, and targeting of non-natural cytokine receptor complexes. Here, we survey synthetic cytokine developments within the IL-6-type cytokine family and discuss potential clinical applications." @default.
- W4384819931 created "2023-07-21" @default.
- W4384819931 creator A5027842348 @default.
- W4384819931 creator A5034675603 @default.
- W4384819931 creator A5035488878 @default.
- W4384819931 creator A5044381547 @default.
- W4384819931 creator A5088470216 @default.
- W4384819931 creator A5090222294 @default.
- W4384819931 date "2023-07-28" @default.
- W4384819931 modified "2023-10-16" @default.
- W4384819931 title "Exploring the landscape of synthetic <scp>IL</scp>‐6‐type cytokines" @default.
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