Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384820525> ?p ?o ?g. }
- W4384820525 endingPage "7283" @default.
- W4384820525 startingPage "7270" @default.
- W4384820525 abstract "The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl isothiocyanate ((R)-8-OITC), present in watercress, based on the DAG methodology as well as to evaluate its potential antioxidant and immunomodulatory effects, exploring possible signaling pathways that could be involved in an ex vivo model of murine peritoneal macrophages stimulated with LPS. Treatment with (R)-8-OITC inhibited the levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-17 and IL-18), intracellular ROS production and expression of pro-inflammatory enzymes (COX-2, iNOS and mPGES-1) through modulation of the expression of Nrf2, MAPKs (p38, JNK and ERK) and JAK/STAT, and the canonical and non-canonical pathways of the inflammasome. Taking all these together, our results provide a rapid and cost-effective synthetic route to obtain natural (R)-8-OITC and demonstrate that it could be a potential nutraceutical candidate for managing immuno-inflammatory pathologies. Therefore, further in vivo trials are warranted." @default.
- W4384820525 created "2023-07-21" @default.
- W4384820525 creator A5000838605 @default.
- W4384820525 creator A5032710486 @default.
- W4384820525 creator A5041600573 @default.
- W4384820525 creator A5058937843 @default.
- W4384820525 creator A5067041688 @default.
- W4384820525 creator A5075228356 @default.
- W4384820525 date "2023-01-01" @default.
- W4384820525 modified "2023-10-01" @default.
- W4384820525 title "(<i>R</i>)-8-Methylsulfinyloctyl isothiocyanate from <i>Nasturtium officinale</i> inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved" @default.
- W4384820525 cites W1593139023 @default.
- W4384820525 cites W1770528611 @default.
- W4384820525 cites W1968415443 @default.
- W4384820525 cites W1971687421 @default.
- W4384820525 cites W2000683085 @default.
- W4384820525 cites W2003437276 @default.
- W4384820525 cites W2004279029 @default.
- W4384820525 cites W2012355099 @default.
- W4384820525 cites W2020954114 @default.
- W4384820525 cites W2026056562 @default.
- W4384820525 cites W2027605855 @default.
- W4384820525 cites W2030898736 @default.
- W4384820525 cites W2036606290 @default.
- W4384820525 cites W2046489840 @default.
- W4384820525 cites W2053836684 @default.
- W4384820525 cites W2057933723 @default.
- W4384820525 cites W2058824214 @default.
- W4384820525 cites W2063618329 @default.
- W4384820525 cites W2069962876 @default.
- W4384820525 cites W2082926347 @default.
- W4384820525 cites W2083601669 @default.
- W4384820525 cites W2095419099 @default.
- W4384820525 cites W2109689528 @default.
- W4384820525 cites W2115997206 @default.
- W4384820525 cites W2129142949 @default.
- W4384820525 cites W2131150261 @default.
- W4384820525 cites W2132720660 @default.
- W4384820525 cites W2135438293 @default.
- W4384820525 cites W2137124318 @default.
- W4384820525 cites W2137622838 @default.
- W4384820525 cites W2146904173 @default.
- W4384820525 cites W2156582599 @default.
- W4384820525 cites W2167426231 @default.
- W4384820525 cites W2174018465 @default.
- W4384820525 cites W2252895274 @default.
- W4384820525 cites W2254315882 @default.
- W4384820525 cites W2296733663 @default.
- W4384820525 cites W2330030716 @default.
- W4384820525 cites W2331046130 @default.
- W4384820525 cites W2522038806 @default.
- W4384820525 cites W2551075488 @default.
- W4384820525 cites W2606156871 @default.
- W4384820525 cites W2620178097 @default.
- W4384820525 cites W2732175055 @default.
- W4384820525 cites W2774336664 @default.
- W4384820525 cites W2778714233 @default.
- W4384820525 cites W2784290180 @default.
- W4384820525 cites W2789749973 @default.
- W4384820525 cites W2791527839 @default.
- W4384820525 cites W2801413673 @default.
- W4384820525 cites W2801546633 @default.
- W4384820525 cites W2807028458 @default.
- W4384820525 cites W2897450030 @default.
- W4384820525 cites W2901842078 @default.
- W4384820525 cites W2903108867 @default.
- W4384820525 cites W2943066477 @default.
- W4384820525 cites W2949410348 @default.
- W4384820525 cites W2951334415 @default.
- W4384820525 cites W2951801120 @default.
- W4384820525 cites W2952302200 @default.
- W4384820525 cites W2971582004 @default.
- W4384820525 cites W2989989861 @default.
- W4384820525 cites W3011500752 @default.
- W4384820525 cites W3021288299 @default.
- W4384820525 cites W3193304619 @default.
- W4384820525 cites W3203151570 @default.
- W4384820525 cites W3204889904 @default.
- W4384820525 cites W3215259139 @default.
- W4384820525 cites W3216146155 @default.
- W4384820525 cites W4206916966 @default.
- W4384820525 cites W4210292994 @default.
- W4384820525 cites W4220953633 @default.
- W4384820525 cites W4226198645 @default.
- W4384820525 cites W4281676404 @default.
- W4384820525 cites W4283270579 @default.
- W4384820525 cites W4284668980 @default.
- W4384820525 cites W4289939586 @default.
- W4384820525 cites W4293247451 @default.
- W4384820525 cites W4307944495 @default.
- W4384820525 cites W4311724886 @default.
- W4384820525 cites W4380421873 @default.
- W4384820525 doi "https://doi.org/10.1039/d3fo02009f" @default.
- W4384820525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37469300" @default.
- W4384820525 hasPublicationYear "2023" @default.
- W4384820525 type Work @default.
- W4384820525 citedByCount "0" @default.
- W4384820525 crossrefType "journal-article" @default.