Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384822723> ?p ?o ?g. }
- W4384822723 abstract "Background Breast cancer (BRCA) has become the most diagnosed cancer worldwide for female and seriously endanger female health. The epithelial-mesenchymal transition (EMT) process is associated with metastasis and drug resistance in BRCA patients. However, the prognostic value of EMT-related lncRNA in BRCA still needs to be revealed. The aim of this study is to construct an EMT-related lncRNA (ERL) signature with accuracy predictive ability for the prognosis of BRCA patients. Methods RNA-seq expression data and Clinical characteristics obtained from the TCGA (The Cancer Genome Atlas) were used in the study. First, we identified the EMT-related lncRNA by the Pearson correlation analysis. An EMT-related lncRNAs prognostic risk signature was constructed using univariate Cox regression and Lasso-penalized Cox regression analyses. The model’s performance was validated using Kaplan-Meier (KM) survival analysis, ROC curve and C-index. Finally, a nomogram was constructed for clinical practice in evaluating the patients with BRCA and validated by calibration curve and decision curve analysis (DCA). We also evaluated the drug sensitivity of signature lncRNA and the tumor immune cell infiltration in breast cancer. Results We constructed a 10-lncRNA risk score signature based on the lncRNAs associated with the EMT process. We could assign BRCA patients to the high- and low-risk group according to the median risk score. The prognostic risk signature showed excellent accuracy and demonstrated sufficient independence from other clinical characteristics. The immune cell infiltration analysis showed that the prognostic risk signature was related to the infiltration of the immune cell subtype. Drug sensitivity analysis proved ERLs signature could effectively predict the sensitivity of patients to common chemotherapy drugs in BRCA and provide guidance for chemotherapy drugs for high-risk and low-risk patients. Conclusion Our ERL signature and nomogram have excellent prognostic value and could become reliable tools for clinical guidance." @default.
- W4384822723 created "2023-07-21" @default.
- W4384822723 creator A5001614863 @default.
- W4384822723 creator A5001940565 @default.
- W4384822723 creator A5024693945 @default.
- W4384822723 creator A5048684619 @default.
- W4384822723 creator A5053776466 @default.
- W4384822723 creator A5058418918 @default.
- W4384822723 creator A5078594719 @default.
- W4384822723 creator A5089061578 @default.
- W4384822723 creator A5090035531 @default.
- W4384822723 date "2023-07-19" @default.
- W4384822723 modified "2023-09-26" @default.
- W4384822723 title "Exploration of epithelial-mesenchymal transition-related lncRNA signature and drug sensitivity in breast cancer" @default.
- W4384822723 cites W1008665223 @default.
- W4384822723 cites W1917948530 @default.
- W4384822723 cites W1964847767 @default.
- W4384822723 cites W1969346276 @default.
- W4384822723 cites W2036008499 @default.
- W4384822723 cites W2045030989 @default.
- W4384822723 cites W2107578668 @default.
- W4384822723 cites W2108459871 @default.
- W4384822723 cites W2129925362 @default.
- W4384822723 cites W2154589460 @default.
- W4384822723 cites W2292574744 @default.
- W4384822723 cites W2336297584 @default.
- W4384822723 cites W2547655849 @default.
- W4384822723 cites W2606960909 @default.
- W4384822723 cites W2744685612 @default.
- W4384822723 cites W2897422388 @default.
- W4384822723 cites W2902061712 @default.
- W4384822723 cites W2914643394 @default.
- W4384822723 cites W2954138733 @default.
- W4384822723 cites W2973225275 @default.
- W4384822723 cites W2990826805 @default.
- W4384822723 cites W2992049627 @default.
- W4384822723 cites W2998201838 @default.
- W4384822723 cites W3016840787 @default.
- W4384822723 cites W3034422358 @default.
- W4384822723 cites W3038099274 @default.
- W4384822723 cites W3040273206 @default.
- W4384822723 cites W3045042716 @default.
- W4384822723 cites W3091833981 @default.
- W4384822723 cites W3093749373 @default.
- W4384822723 cites W3104513837 @default.
- W4384822723 cites W3112895250 @default.
- W4384822723 cites W3121123499 @default.
- W4384822723 cites W3128070820 @default.
- W4384822723 cites W3128646645 @default.
- W4384822723 cites W3139472937 @default.
- W4384822723 cites W3177423319 @default.
- W4384822723 cites W4206841660 @default.
- W4384822723 cites W4214535257 @default.
- W4384822723 cites W4285741613 @default.
- W4384822723 cites W4294992918 @default.
- W4384822723 doi "https://doi.org/10.3389/fendo.2023.1154741" @default.
- W4384822723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37538794" @default.
- W4384822723 hasPublicationYear "2023" @default.
- W4384822723 type Work @default.
- W4384822723 citedByCount "0" @default.
- W4384822723 crossrefType "journal-article" @default.
- W4384822723 hasAuthorship W4384822723A5001614863 @default.
- W4384822723 hasAuthorship W4384822723A5001940565 @default.
- W4384822723 hasAuthorship W4384822723A5024693945 @default.
- W4384822723 hasAuthorship W4384822723A5048684619 @default.
- W4384822723 hasAuthorship W4384822723A5053776466 @default.
- W4384822723 hasAuthorship W4384822723A5058418918 @default.
- W4384822723 hasAuthorship W4384822723A5078594719 @default.
- W4384822723 hasAuthorship W4384822723A5089061578 @default.
- W4384822723 hasAuthorship W4384822723A5090035531 @default.
- W4384822723 hasBestOaLocation W43848227231 @default.
- W4384822723 hasConcept C119857082 @default.
- W4384822723 hasConcept C121608353 @default.
- W4384822723 hasConcept C126322002 @default.
- W4384822723 hasConcept C143998085 @default.
- W4384822723 hasConcept C161584116 @default.
- W4384822723 hasConcept C199163554 @default.
- W4384822723 hasConcept C34626388 @default.
- W4384822723 hasConcept C41008148 @default.
- W4384822723 hasConcept C50382708 @default.
- W4384822723 hasConcept C530470458 @default.
- W4384822723 hasConcept C58471807 @default.
- W4384822723 hasConcept C71924100 @default.
- W4384822723 hasConceptScore W4384822723C119857082 @default.
- W4384822723 hasConceptScore W4384822723C121608353 @default.
- W4384822723 hasConceptScore W4384822723C126322002 @default.
- W4384822723 hasConceptScore W4384822723C143998085 @default.
- W4384822723 hasConceptScore W4384822723C161584116 @default.
- W4384822723 hasConceptScore W4384822723C199163554 @default.
- W4384822723 hasConceptScore W4384822723C34626388 @default.
- W4384822723 hasConceptScore W4384822723C41008148 @default.
- W4384822723 hasConceptScore W4384822723C50382708 @default.
- W4384822723 hasConceptScore W4384822723C530470458 @default.
- W4384822723 hasConceptScore W4384822723C58471807 @default.
- W4384822723 hasConceptScore W4384822723C71924100 @default.
- W4384822723 hasLocation W43848227231 @default.
- W4384822723 hasLocation W43848227232 @default.
- W4384822723 hasLocation W43848227233 @default.
- W4384822723 hasOpenAccess W4384822723 @default.
- W4384822723 hasPrimaryLocation W43848227231 @default.