FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384823193> ?p ?o ?g. }

• W4384823193 endingPage "11598" @default.
• W4384823193 startingPage "11598" @default.
• W4384823193 abstract "NFE2L2 and STAT3 are key pro-survival molecules, and thus, their targeting may represent a promising anti-cancer strategy. In this study, we found that a positive feedback loop occurred between them and provided evidence that their concomitant inhibition efficiently impaired the survival of PEL cells, a rare, aggressive B cell lymphoma associated with the gammaherpesvirus KSHV and often also EBV. At the molecular level, we found that NFE2L2 and STAT3 converged in the regulation of several pro-survival molecules and in the activation of processes essential for the adaption of lymphoma cells to stress. Among those, STAT3 and NFE2L2 promoted the activation of pathways such as MAPK3/1 and MTOR that positively regulate protein synthesis, sustained the antioxidant response, expression of molecules such as MYC, BIRC5, CCND1, and HSP, and allowed DDR execution. The findings of this study suggest that the concomitant inhibition of NFE2L2 and STAT3 may be considered a therapeutic option for the treatment of this lymphoma that poorly responds to chemotherapies." @default.
• W4384823193 created "2023-07-21" @default.
• W4384823193 creator A5000153354 @default.
• W4384823193 creator A5003089486 @default.
• W4384823193 creator A5023216512 @default.
• W4384823193 creator A5038047197 @default.
• W4384823193 creator A5043445114 @default.
• W4384823193 creator A5053618298 @default.
• W4384823193 creator A5056847078 @default.
• W4384823193 creator A5079899338 @default.
• W4384823193 creator A5080124438 @default.
• W4384823193 creator A5080227365 @default.
• W4384823193 date "2023-07-18" @default.
• W4384823193 modified "2023-09-27" @default.
• W4384823193 title "NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells" @default.
• W4384823193 cites W1548282166 @default.
• W4384823193 cites W1596814033 @default.
• W4384823193 cites W1853894947 @default.
• W4384823193 cites W1918200534 @default.
• W4384823193 cites W1998074678 @default.
• W4384823193 cites W2045429389 @default.
• W4384823193 cites W2071960601 @default.
• W4384823193 cites W2085363039 @default.
• W4384823193 cites W2107884498 @default.
• W4384823193 cites W2134128731 @default.
• W4384823193 cites W2143819289 @default.
• W4384823193 cites W2158849686 @default.
• W4384823193 cites W2344726805 @default.
• W4384823193 cites W2529101401 @default.
• W4384823193 cites W2568166803 @default.
• W4384823193 cites W2612428976 @default.
• W4384823193 cites W2735553409 @default.
• W4384823193 cites W2753995352 @default.
• W4384823193 cites W2757965705 @default.
• W4384823193 cites W2759733913 @default.
• W4384823193 cites W2897974793 @default.
• W4384823193 cites W2900569176 @default.
• W4384823193 cites W2906195833 @default.
• W4384823193 cites W2908510319 @default.
• W4384823193 cites W2913626214 @default.
• W4384823193 cites W2986572941 @default.
• W4384823193 cites W2995496224 @default.
• W4384823193 cites W3108936441 @default.
• W4384823193 cites W3111400820 @default.
• W4384823193 cites W3131817009 @default.
• W4384823193 cites W4220949007 @default.
• W4384823193 cites W4283031260 @default.
• W4384823193 cites W4312126395 @default.
• W4384823193 cites W4313361324 @default.
• W4384823193 cites W4321097804 @default.
• W4384823193 cites W4362506574 @default.
• W4384823193 cites W775311174 @default.
• W4384823193 doi "https://doi.org/10.3390/ijms241411598" @default.
• W4384823193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37511362" @default.
• W4384823193 hasPublicationYear "2023" @default.
• W4384823193 type Work @default.
• W4384823193 citedByCount "0" @default.
• W4384823193 crossrefType "journal-article" @default.
• W4384823193 hasAuthorship W4384823193A5000153354 @default.
• W4384823193 hasAuthorship W4384823193A5003089486 @default.
• W4384823193 hasAuthorship W4384823193A5023216512 @default.
• W4384823193 hasAuthorship W4384823193A5038047197 @default.
• W4384823193 hasAuthorship W4384823193A5043445114 @default.
• W4384823193 hasAuthorship W4384823193A5053618298 @default.
• W4384823193 hasAuthorship W4384823193A5056847078 @default.
• W4384823193 hasAuthorship W4384823193A5079899338 @default.
• W4384823193 hasAuthorship W4384823193A5080124438 @default.
• W4384823193 hasAuthorship W4384823193A5080227365 @default.
• W4384823193 hasBestOaLocation W43848231931 @default.
• W4384823193 hasConcept C190283241 @default.
• W4384823193 hasConcept C199835354 @default.
• W4384823193 hasConcept C203014093 @default.
• W4384823193 hasConcept C2778923194 @default.
• W4384823193 hasConcept C2779338263 @default.
• W4384823193 hasConcept C29537977 @default.
• W4384823193 hasConcept C502942594 @default.
• W4384823193 hasConcept C54355233 @default.
• W4384823193 hasConcept C62478195 @default.
• W4384823193 hasConcept C86554907 @default.
• W4384823193 hasConcept C86803240 @default.
• W4384823193 hasConcept C95444343 @default.
• W4384823193 hasConceptScore W4384823193C190283241 @default.
• W4384823193 hasConceptScore W4384823193C199835354 @default.
• W4384823193 hasConceptScore W4384823193C203014093 @default.
• W4384823193 hasConceptScore W4384823193C2778923194 @default.
• W4384823193 hasConceptScore W4384823193C2779338263 @default.
• W4384823193 hasConceptScore W4384823193C29537977 @default.
• W4384823193 hasConceptScore W4384823193C502942594 @default.
• W4384823193 hasConceptScore W4384823193C54355233 @default.
• W4384823193 hasConceptScore W4384823193C62478195 @default.
• W4384823193 hasConceptScore W4384823193C86554907 @default.
• W4384823193 hasConceptScore W4384823193C86803240 @default.
• W4384823193 hasConceptScore W4384823193C95444343 @default.
• W4384823193 hasIssue "14" @default.
• W4384823193 hasLocation W43848231931 @default.
• W4384823193 hasLocation W43848231932 @default.
• W4384823193 hasLocation W43848231933 @default.
• W4384823193 hasOpenAccess W4384823193 @default.

• next