Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384825906> ?p ?o ?g. }
- W4384825906 abstract "Rheumatic heart disease (RHD) remains a significant cardiovascular burden in the world even though it is no longer common in affluent countries. Centuries of history surrounding this disease provide us with a thorough understanding of its pathophysiology. Infections in the throat, skin, or mucosa are the gateway for Group A Streptococcus (GAS) to penetrate our immune system. A significant inflammatory response to the heart is caused by an immunologic cascade triggered by GAS antigen cross-reactivity. This exaggerated immune response is primarily responsible for cardiac dysfunction. Recurrent inflammatory processes damage all layers of the heart, including the endocardium, myocardium, and pericardium. A vicious immunological cycle involving inflammatory mediators, angiotensin II, and TGF-β promotes extracellular matrix remodeling, resulting in myocardial fibrosis. Myocardial fibrosis appears to be a prevalent occurrence in patients with RHD. The presence of myocardial fibrosis, which causes left ventricular dysfunction in RHD, might be utilized to determine options for treatment and might also be used to predict the outcome of interventions in patients with RHD. This emerging concept of myocardial fibrosis needs to be explored comprehensively in order to be optimally utilized in the treatment of RHD." @default.
- W4384825906 created "2023-07-21" @default.
- W4384825906 creator A5006789526 @default.
- W4384825906 creator A5009188407 @default.
- W4384825906 creator A5015575116 @default.
- W4384825906 creator A5031019247 @default.
- W4384825906 creator A5048854156 @default.
- W4384825906 creator A5072465854 @default.
- W4384825906 creator A5074236268 @default.
- W4384825906 creator A5092501385 @default.
- W4384825906 date "2023-07-19" @default.
- W4384825906 modified "2023-09-25" @default.
- W4384825906 title "Myocardial fibrosis in rheumatic heart disease: emerging concepts and clinical implications" @default.
- W4384825906 cites W1505781457 @default.
- W4384825906 cites W1607131709 @default.
- W4384825906 cites W1827424830 @default.
- W4384825906 cites W1966583321 @default.
- W4384825906 cites W1970491623 @default.
- W4384825906 cites W1973621736 @default.
- W4384825906 cites W1977779005 @default.
- W4384825906 cites W1980745547 @default.
- W4384825906 cites W1981887823 @default.
- W4384825906 cites W1982716497 @default.
- W4384825906 cites W1987814308 @default.
- W4384825906 cites W1989338200 @default.
- W4384825906 cites W1993148317 @default.
- W4384825906 cites W1993916154 @default.
- W4384825906 cites W2005075107 @default.
- W4384825906 cites W2008374414 @default.
- W4384825906 cites W2012657883 @default.
- W4384825906 cites W2022047427 @default.
- W4384825906 cites W2025383517 @default.
- W4384825906 cites W2042846373 @default.
- W4384825906 cites W2052763302 @default.
- W4384825906 cites W2053570696 @default.
- W4384825906 cites W2066557507 @default.
- W4384825906 cites W2068650532 @default.
- W4384825906 cites W2069738462 @default.
- W4384825906 cites W2075057943 @default.
- W4384825906 cites W2075460902 @default.
- W4384825906 cites W2080353562 @default.
- W4384825906 cites W2096309150 @default.
- W4384825906 cites W2096847688 @default.
- W4384825906 cites W2099195251 @default.
- W4384825906 cites W2105539777 @default.
- W4384825906 cites W2107495112 @default.
- W4384825906 cites W2116907750 @default.
- W4384825906 cites W2121179755 @default.
- W4384825906 cites W2126799104 @default.
- W4384825906 cites W2129674266 @default.
- W4384825906 cites W2132250523 @default.
- W4384825906 cites W2135715593 @default.
- W4384825906 cites W2147834257 @default.
- W4384825906 cites W2152073168 @default.
- W4384825906 cites W2152370764 @default.
- W4384825906 cites W2155744534 @default.
- W4384825906 cites W2156806750 @default.
- W4384825906 cites W2157718451 @default.
- W4384825906 cites W2299099463 @default.
- W4384825906 cites W2335658573 @default.
- W4384825906 cites W2336680030 @default.
- W4384825906 cites W2342679639 @default.
- W4384825906 cites W2411552344 @default.
- W4384825906 cites W2412607644 @default.
- W4384825906 cites W2413024132 @default.
- W4384825906 cites W2472620246 @default.
- W4384825906 cites W2477296140 @default.
- W4384825906 cites W2582366378 @default.
- W4384825906 cites W2684628620 @default.
- W4384825906 cites W2746455801 @default.
- W4384825906 cites W2750996608 @default.
- W4384825906 cites W2810736670 @default.
- W4384825906 cites W2890515546 @default.
- W4384825906 cites W2890745008 @default.
- W4384825906 cites W2904754296 @default.
- W4384825906 cites W2946971162 @default.
- W4384825906 cites W2965017770 @default.
- W4384825906 cites W3026160377 @default.
- W4384825906 cites W3045698292 @default.
- W4384825906 cites W3082384794 @default.
- W4384825906 cites W3082684991 @default.
- W4384825906 cites W3108873883 @default.
- W4384825906 cites W3116592509 @default.
- W4384825906 cites W3195842247 @default.
- W4384825906 cites W3199134937 @default.
- W4384825906 cites W4206379265 @default.
- W4384825906 cites W4210607007 @default.
- W4384825906 cites W4211066982 @default.
- W4384825906 cites W4231702410 @default.
- W4384825906 cites W4304172238 @default.
- W4384825906 cites W4304471552 @default.
- W4384825906 cites W4312178876 @default.
- W4384825906 cites W73470179 @default.
- W4384825906 doi "https://doi.org/10.3389/fcvm.2023.1230894" @default.
- W4384825906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37564912" @default.
- W4384825906 hasPublicationYear "2023" @default.
- W4384825906 type Work @default.
- W4384825906 citedByCount "0" @default.
- W4384825906 crossrefType "journal-article" @default.
- W4384825906 hasAuthorship W4384825906A5006789526 @default.