FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384828887> ?p ?o ?g. }

• W4384828887 abstract "Abstract APOBEC3s are powerful human anti-viral proteins that inhibit viral replication and proliferation by inducing mutations in viral genomes. We found that in the regulatory region of the APOBEC3 cluster on human chromosome 22, there exist three distinct haplogroups that began to have diverged nearly 1 million years ago and have since been maintained in both African and non-African populations today. Despite the long persistence time of the haplogroups, one of which is shared by archaic hominins, we also found that the nucleotide diversity within each haplogroup is extremely low. With a simulation-based method, the observed low diversity within haplogroups and large divergence between haplogroups suggested that these haplogroups have been maintained by special forms of positive Darwinian selection. Repeated occurrence of such selection entails the enhanced substitution rate in this regulatory region in both the human and chimpanzee lineages. The causal events of such positive selection, which are most likely viral epidemics, are shown to have occurred at least three times in the modern human population: one before the Out-of-Africa migration and another two in the common ancestors of non-Africans." @default.
• W4384828887 created "2023-07-21" @default.
• W4384828887 creator A5009291354 @default.
• W4384828887 creator A5011503775 @default.
• W4384828887 creator A5049195099 @default.
• W4384828887 creator A5055009720 @default.
• W4384828887 date "2023-07-19" @default.
• W4384828887 modified "2023-09-24" @default.
• W4384828887 title "Distinct haplogroups with star-like diversification in the APOBEC3 regulatory region indicate ancient viral pandemics before and during the Out-of-Africa migration of modern humans" @default.
• W4384828887 cites W1929921649 @default.
• W4384828887 cites W1964918240 @default.
• W4384828887 cites W1976844960 @default.
• W4384828887 cites W1978469053 @default.
• W4384828887 cites W1979692277 @default.
• W4384828887 cites W1987208099 @default.
• W4384828887 cites W2003665515 @default.
• W4384828887 cites W2009148864 @default.
• W4384828887 cites W2025253353 @default.
• W4384828887 cites W2027613370 @default.
• W4384828887 cites W2036886202 @default.
• W4384828887 cites W2039435867 @default.
• W4384828887 cites W2047998066 @default.
• W4384828887 cites W2064306519 @default.
• W4384828887 cites W2085458745 @default.
• W4384828887 cites W2097706568 @default.
• W4384828887 cites W2104549677 @default.
• W4384828887 cites W2130783116 @default.
• W4384828887 cites W2134599124 @default.
• W4384828887 cites W2135124067 @default.
• W4384828887 cites W2149992227 @default.
• W4384828887 cites W2152061559 @default.
• W4384828887 cites W2157644433 @default.
• W4384828887 cites W2157876432 @default.
• W4384828887 cites W2161644980 @default.
• W4384828887 cites W2164547119 @default.
• W4384828887 cites W2304458632 @default.
• W4384828887 cites W2416193592 @default.
• W4384828887 cites W2523102210 @default.
• W4384828887 cites W2523216993 @default.
• W4384828887 cites W2531014594 @default.
• W4384828887 cites W2586691160 @default.
• W4384828887 cites W2756712855 @default.
• W4384828887 cites W2776364113 @default.
• W4384828887 cites W2883926193 @default.
• W4384828887 cites W2892722395 @default.
• W4384828887 cites W2949631853 @default.
• W4384828887 cites W2995182672 @default.
• W4384828887 cites W2995538840 @default.
• W4384828887 cites W3004480399 @default.
• W4384828887 cites W3090171353 @default.
• W4384828887 cites W3092440463 @default.
• W4384828887 cites W3130788486 @default.
• W4384828887 cites W4225554954 @default.
• W4384828887 cites W4251751280 @default.
• W4384828887 cites W4294012180 @default.
• W4384828887 cites W4306810879 @default.
• W4384828887 cites W4362698837 @default.
• W4384828887 doi "https://doi.org/10.1101/2023.07.18.549600" @default.
• W4384828887 hasPublicationYear "2023" @default.
• W4384828887 type Work @default.
• W4384828887 citedByCount "0" @default.
• W4384828887 crossrefType "posted-content" @default.
• W4384828887 hasAuthorship W4384828887A5009291354 @default.
• W4384828887 hasAuthorship W4384828887A5011503775 @default.
• W4384828887 hasAuthorship W4384828887A5049195099 @default.
• W4384828887 hasAuthorship W4384828887A5055009720 @default.
• W4384828887 hasBestOaLocation W43848288871 @default.
• W4384828887 hasConcept C104317684 @default.
• W4384828887 hasConcept C141231307 @default.
• W4384828887 hasConcept C142724271 @default.
• W4384828887 hasConcept C144024400 @default.
• W4384828887 hasConcept C149923435 @default.
• W4384828887 hasConcept C154945302 @default.
• W4384828887 hasConcept C170595211 @default.
• W4384828887 hasConcept C180754005 @default.
• W4384828887 hasConcept C197754878 @default.
• W4384828887 hasConcept C201526758 @default.
• W4384828887 hasConcept C2779134260 @default.
• W4384828887 hasConcept C2908647359 @default.
• W4384828887 hasConcept C3008058167 @default.
• W4384828887 hasConcept C41008148 @default.
• W4384828887 hasConcept C524204448 @default.
• W4384828887 hasConcept C54355233 @default.
• W4384828887 hasConcept C71924100 @default.
• W4384828887 hasConcept C7386963 @default.
• W4384828887 hasConcept C78450430 @default.
• W4384828887 hasConcept C78458016 @default.
• W4384828887 hasConcept C81917197 @default.
• W4384828887 hasConcept C86803240 @default.
• W4384828887 hasConcept C89623803 @default.
• W4384828887 hasConceptScore W4384828887C104317684 @default.
• W4384828887 hasConceptScore W4384828887C141231307 @default.
• W4384828887 hasConceptScore W4384828887C142724271 @default.
• W4384828887 hasConceptScore W4384828887C144024400 @default.
• W4384828887 hasConceptScore W4384828887C149923435 @default.
• W4384828887 hasConceptScore W4384828887C154945302 @default.
• W4384828887 hasConceptScore W4384828887C170595211 @default.
• W4384828887 hasConceptScore W4384828887C180754005 @default.
• W4384828887 hasConceptScore W4384828887C197754878 @default.
• W4384828887 hasConceptScore W4384828887C201526758 @default.

• next