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- W4384829368 abstract "Abstract Altered gene expressions may mechanistically link genetic factors with brain morphometric alterations. Existing gene expression studies have examined selected morphometric features using low-resolution atlases in medicated schizophrenia. We examined the relationship of gene expression with cortical thickness (CT), surface area (SA), and gray matter volume (GMV) of first-episode antipsychotic-naïve psychosis patients (FEAP = 85) and 81 controls, hypothesizing that gene expressions often associated with psychosis will differentially associate with different morphometric features. We explored such associations among schizophrenia and non-schizophrenia subgroups within FEAP group compared to controls. We mapped 360 Human Connectome Project atlas-based parcellations on brain MRI on to the publicly available brain gene expression data from the Allen Brain Institute collection. Significantly correlated genes were investigated using ingenuity pathway analysis to elucidate molecular pathways. CT but not SA or GMV correlated with expression of 1137 out of 15 633 genes examined controlling for age, sex, and average CT. Among these ≈19%, ≈39%, and 8% of genes were unique to FEAP, schizophrenia, and non-schizophrenia, respectively. Variants of 10 among these 1137 correlated genes previously showed genome-wide-association with schizophrenia. Molecular pathways associated with CT were axonal guidance and sphingosine pathways (common to FEAP and controls), selected inflammation pathways (unique to FEAP), synaptic modulation (unique to schizophrenia), and telomere extension (common to NSZ and healthy controls). We demonstrate that different sets of genes and molecular pathways may preferentially influence CT in different diagnostic groups. Genes with altered expressions correlating with CT and associated pathways may be targets for pathophysiological investigations and novel treatment designs." @default.
- W4384829368 created "2023-07-21" @default.
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- W4384829368 date "2023-01-01" @default.
- W4384829368 modified "2023-10-15" @default.
- W4384829368 title "Gene Expressions Preferentially Influence Cortical Thickness of Human Connectome Project Atlas Parcellated Regions in First-Episode Antipsychotic-Naïve Psychoses" @default.
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- W4384829368 cites W1996074635 @default.
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- W4384829368 cites W2007298996 @default.
- W4384829368 cites W2007697184 @default.
- W4384829368 cites W2008349386 @default.
- W4384829368 cites W2008708465 @default.
- W4384829368 cites W2015964634 @default.
- W4384829368 cites W2017409008 @default.
- W4384829368 cites W2017508922 @default.
- W4384829368 cites W2029287634 @default.
- W4384829368 cites W2031374500 @default.
- W4384829368 cites W2038061678 @default.
- W4384829368 cites W2048049925 @default.
- W4384829368 cites W2054238640 @default.
- W4384829368 cites W2057014456 @default.
- W4384829368 cites W2057613044 @default.
- W4384829368 cites W2058130721 @default.
- W4384829368 cites W2072901107 @default.
- W4384829368 cites W2072985930 @default.
- W4384829368 cites W2074814583 @default.
- W4384829368 cites W2079381061 @default.
- W4384829368 cites W2082559397 @default.
- W4384829368 cites W2084478104 @default.
- W4384829368 cites W2101135654 @default.
- W4384829368 cites W2101357408 @default.
- W4384829368 cites W2102581653 @default.
- W4384829368 cites W2102801681 @default.
- W4384829368 cites W2109273096 @default.
- W4384829368 cites W2111884236 @default.
- W4384829368 cites W2130793535 @default.
- W4384829368 cites W2131555617 @default.
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- W4384829368 cites W2134783591 @default.
- W4384829368 cites W2139942051 @default.
- W4384829368 cites W2163212678 @default.
- W4384829368 cites W2163337838 @default.
- W4384829368 cites W2170899856 @default.
- W4384829368 cites W2237883872 @default.
- W4384829368 cites W2260830658 @default.
- W4384829368 cites W2276230036 @default.
- W4384829368 cites W2497939844 @default.
- W4384829368 cites W2499800833 @default.
- W4384829368 cites W2507387536 @default.
- W4384829368 cites W2519735684 @default.
- W4384829368 cites W2523916470 @default.
- W4384829368 cites W2528626580 @default.
- W4384829368 cites W2618015181 @default.
- W4384829368 cites W2742494644 @default.
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- W4384829368 cites W2797660976 @default.
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- W4384829368 cites W2951347155 @default.
- W4384829368 cites W2952215064 @default.
- W4384829368 cites W2978697055 @default.
- W4384829368 cites W3009085602 @default.
- W4384829368 cites W3080158422 @default.
- W4384829368 cites W3081914577 @default.
- W4384829368 cites W3083142180 @default.
- W4384829368 cites W3118751097 @default.
- W4384829368 cites W3122054437 @default.
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- W4384829368 cites W3133688715 @default.
- W4384829368 cites W3150955986 @default.
- W4384829368 cites W3157367842 @default.
- W4384829368 cites W3166212629 @default.
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- W4384829368 cites W3189246539 @default.
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- W4384829368 cites W4282937011 @default.
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- W4384829368 cites W4313531976 @default.
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- W4384829368 doi "https://doi.org/10.1093/schizbullopen/sgad019" @default.
- W4384829368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37621304" @default.
- W4384829368 hasPublicationYear "2023" @default.
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