Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384829507> ?p ?o ?g. }
- W4384829507 abstract "ABSTRACT CD4 T follicular helper cells (T fh ) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into T fh subsets that promote antibody persistence and functional capacity can critically inform vaccine design. Based on the T fh profiles evoked by the live attenuated measles virus vaccine, renowned for its ability to establish durable humoral immunity, we investigated the potential of a T fh 1/17 recall response during the boost phase to enhance persistence of HIV-1 Envelope (Env) antibodies in rhesus macaques. Using a DNA-prime encoding gp160 antigen and T fh polarizing cytokines (interferon protein-10 (IP-10) and interleukin-6 (IL-6)), followed by a gp140 protein boost formulated in a cationic liposome-based adjuvant (CAF01), we successfully generated germinal center (GC) T fh 1/17 cells. In contrast, a similar DNA-prime (including IP-10) followed by gp140 formulated with monophosphoryl lipid A (MPLA)+QS-21 adjuvant predominantly induced GC T fh 1 cells. While the generation of GC T fh 1/17 cells with CAF01 and GC T fh 1 cells with MPLA+QS-21 induced comparable peak Env antibodies, the latter group demonstrated significantly greater antibody concentrations at week 8 after final immunization which persisted up to 30 weeks (gp140 IgG ng/ml- MPLA; 5500; CAF01, 2155; p <0.05). Notably, interferon γ+ Env-specific T fh responses were consistently higher with gp140 in MPLA+QS-21 and positively correlated with Env antibody persistence. These findings suggest that vaccine platforms maximizing GC T fh 1 induction promote persistent Env antibodies, important for protective immunity against HIV." @default.
- W4384829507 created "2023-07-21" @default.
- W4384829507 creator A5016344007 @default.
- W4384829507 creator A5024425772 @default.
- W4384829507 creator A5032394563 @default.
- W4384829507 creator A5034536696 @default.
- W4384829507 creator A5035756733 @default.
- W4384829507 creator A5048150333 @default.
- W4384829507 creator A5052768263 @default.
- W4384829507 creator A5065393547 @default.
- W4384829507 creator A5081777934 @default.
- W4384829507 creator A5086530398 @default.
- W4384829507 creator A5088274664 @default.
- W4384829507 creator A5090748088 @default.
- W4384829507 date "2023-07-19" @default.
- W4384829507 modified "2023-09-24" @default.
- W4384829507 title "Tailoring T<sub>fh</sub>Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques" @default.
- W4384829507 cites W1607536760 @default.
- W4384829507 cites W2001194497 @default.
- W4384829507 cites W2001775594 @default.
- W4384829507 cites W2003687800 @default.
- W4384829507 cites W2010774677 @default.
- W4384829507 cites W2012706589 @default.
- W4384829507 cites W2015246546 @default.
- W4384829507 cites W2016844693 @default.
- W4384829507 cites W2035618305 @default.
- W4384829507 cites W2036260143 @default.
- W4384829507 cites W2046820608 @default.
- W4384829507 cites W2074374263 @default.
- W4384829507 cites W2113365377 @default.
- W4384829507 cites W2122702059 @default.
- W4384829507 cites W2130410032 @default.
- W4384829507 cites W2137613681 @default.
- W4384829507 cites W2138207763 @default.
- W4384829507 cites W2147458593 @default.
- W4384829507 cites W2156961356 @default.
- W4384829507 cites W2169456326 @default.
- W4384829507 cites W2169955081 @default.
- W4384829507 cites W2179438025 @default.
- W4384829507 cites W2406250479 @default.
- W4384829507 cites W2594844287 @default.
- W4384829507 cites W2766512135 @default.
- W4384829507 cites W2792738458 @default.
- W4384829507 cites W2793009066 @default.
- W4384829507 cites W2806103344 @default.
- W4384829507 cites W2899440123 @default.
- W4384829507 cites W2905444998 @default.
- W4384829507 cites W2912709864 @default.
- W4384829507 cites W2950187344 @default.
- W4384829507 cites W3023701177 @default.
- W4384829507 cites W3024798485 @default.
- W4384829507 cites W3042310203 @default.
- W4384829507 cites W3089239662 @default.
- W4384829507 cites W3157209548 @default.
- W4384829507 cites W3165362378 @default.
- W4384829507 cites W4284987938 @default.
- W4384829507 cites W4317435171 @default.
- W4384829507 doi "https://doi.org/10.1101/2023.07.18.549515" @default.
- W4384829507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37503150" @default.
- W4384829507 hasPublicationYear "2023" @default.
- W4384829507 type Work @default.
- W4384829507 citedByCount "0" @default.
- W4384829507 crossrefType "posted-content" @default.
- W4384829507 hasAuthorship W4384829507A5016344007 @default.
- W4384829507 hasAuthorship W4384829507A5024425772 @default.
- W4384829507 hasAuthorship W4384829507A5032394563 @default.
- W4384829507 hasAuthorship W4384829507A5034536696 @default.
- W4384829507 hasAuthorship W4384829507A5035756733 @default.
- W4384829507 hasAuthorship W4384829507A5048150333 @default.
- W4384829507 hasAuthorship W4384829507A5052768263 @default.
- W4384829507 hasAuthorship W4384829507A5065393547 @default.
- W4384829507 hasAuthorship W4384829507A5081777934 @default.
- W4384829507 hasAuthorship W4384829507A5086530398 @default.
- W4384829507 hasAuthorship W4384829507A5088274664 @default.
- W4384829507 hasAuthorship W4384829507A5090748088 @default.
- W4384829507 hasBestOaLocation W43848295071 @default.
- W4384829507 hasConcept C147483822 @default.
- W4384829507 hasConcept C159047783 @default.
- W4384829507 hasConcept C159654299 @default.
- W4384829507 hasConcept C167508917 @default.
- W4384829507 hasConcept C203014093 @default.
- W4384829507 hasConcept C2777863537 @default.
- W4384829507 hasConcept C2778190748 @default.
- W4384829507 hasConcept C2778453870 @default.
- W4384829507 hasConcept C2779359726 @default.
- W4384829507 hasConcept C2780195530 @default.
- W4384829507 hasConcept C2780801004 @default.
- W4384829507 hasConcept C86803240 @default.
- W4384829507 hasConcept C96926380 @default.
- W4384829507 hasConceptScore W4384829507C147483822 @default.
- W4384829507 hasConceptScore W4384829507C159047783 @default.
- W4384829507 hasConceptScore W4384829507C159654299 @default.
- W4384829507 hasConceptScore W4384829507C167508917 @default.
- W4384829507 hasConceptScore W4384829507C203014093 @default.
- W4384829507 hasConceptScore W4384829507C2777863537 @default.
- W4384829507 hasConceptScore W4384829507C2778190748 @default.
- W4384829507 hasConceptScore W4384829507C2778453870 @default.
- W4384829507 hasConceptScore W4384829507C2779359726 @default.
- W4384829507 hasConceptScore W4384829507C2780195530 @default.
- W4384829507 hasConceptScore W4384829507C2780801004 @default.