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- W4384829768 endingPage "953" @default.
- W4384829768 startingPage "953" @default.
- W4384829768 abstract "More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investigate the consequences of infections and identify novel treatment options, in vivo models are of particular relevance. The mouse has emerged as an economical small animal model to investigate herpesvirus infections. However, except for herpes simplex viruses (HSV-1, HSV-2), human herpesviruses cannot infect mice. Three natural herpesviruses have been identified in mice: mouse-derived cytomegalovirus (MCMV), mouse herpesvirus 68 (MHV-68), and mouse roseolovirus (MRV). These orthologues are broadly used to investigate herpesvirus infections within the natural host. In the last few decades, immunocompromised mouse models have been developed, allowing the functional engraftment of various human cells and tissues. These xenograft mice represent valuable model systems to investigate human-restricted viruses, making them particularly relevant for herpesvirus research. In this review, we describe the various mouse models used to study human herpesviruses, thereby highlighting their potential and limitations. Emphasis is laid on xenograft mouse models, covering the development and refinement of immune-compromised mice and their application in herpesvirus research." @default.
- W4384829768 created "2023-07-21" @default.
- W4384829768 creator A5029863936 @default.
- W4384829768 creator A5065508051 @default.
- W4384829768 creator A5073967712 @default.
- W4384829768 date "2023-07-19" @default.
- W4384829768 modified "2023-10-14" @default.
- W4384829768 title "Mouse Models for Human Herpesviruses" @default.
- W4384829768 cites W1515620844 @default.
- W4384829768 cites W1523160694 @default.
- W4384829768 cites W1551102474 @default.
- W4384829768 cites W1576688622 @default.
- W4384829768 cites W1582246051 @default.
- W4384829768 cites W1750074072 @default.
- W4384829768 cites W1848004285 @default.
- W4384829768 cites W1903481747 @default.
- W4384829768 cites W1960875808 @default.
- W4384829768 cites W1969476366 @default.
- W4384829768 cites W1970232857 @default.
- W4384829768 cites W1970910239 @default.
- W4384829768 cites W1972044265 @default.
- W4384829768 cites W1975967746 @default.
- W4384829768 cites W1976701849 @default.
- W4384829768 cites W1980439269 @default.
- W4384829768 cites W1981892114 @default.
- W4384829768 cites W1984823254 @default.
- W4384829768 cites W1986052682 @default.
- W4384829768 cites W1988125746 @default.
- W4384829768 cites W1989877475 @default.
- W4384829768 cites W1993317263 @default.
- W4384829768 cites W1996664062 @default.
- W4384829768 cites W1999253174 @default.
- W4384829768 cites W2007726567 @default.
- W4384829768 cites W2007987850 @default.
- W4384829768 cites W2010519150 @default.
- W4384829768 cites W2014725234 @default.
- W4384829768 cites W2016029960 @default.
- W4384829768 cites W2016303748 @default.
- W4384829768 cites W2016917436 @default.
- W4384829768 cites W2024454437 @default.
- W4384829768 cites W2025563104 @default.
- W4384829768 cites W2026696908 @default.
- W4384829768 cites W2032704387 @default.
- W4384829768 cites W2036053468 @default.
- W4384829768 cites W2036606193 @default.
- W4384829768 cites W2037010689 @default.
- W4384829768 cites W2038363431 @default.
- W4384829768 cites W2046007472 @default.
- W4384829768 cites W2046560815 @default.
- W4384829768 cites W2047698252 @default.
- W4384829768 cites W2049356309 @default.
- W4384829768 cites W2054022085 @default.
- W4384829768 cites W2054296281 @default.
- W4384829768 cites W2055617460 @default.
- W4384829768 cites W2055892558 @default.
- W4384829768 cites W2056687480 @default.
- W4384829768 cites W2058113966 @default.
- W4384829768 cites W2058268968 @default.
- W4384829768 cites W2061600924 @default.
- W4384829768 cites W2063082418 @default.
- W4384829768 cites W2063892379 @default.
- W4384829768 cites W2065183510 @default.
- W4384829768 cites W2067194336 @default.
- W4384829768 cites W2069392425 @default.
- W4384829768 cites W2073357767 @default.
- W4384829768 cites W2073489229 @default.
- W4384829768 cites W2075062907 @default.
- W4384829768 cites W2078286200 @default.
- W4384829768 cites W2080800959 @default.
- W4384829768 cites W2081900413 @default.
- W4384829768 cites W2083208889 @default.
- W4384829768 cites W2089882065 @default.
- W4384829768 cites W2095356884 @default.
- W4384829768 cites W2096464703 @default.
- W4384829768 cites W2096881439 @default.
- W4384829768 cites W2099645260 @default.
- W4384829768 cites W2102030590 @default.
- W4384829768 cites W2103248777 @default.
- W4384829768 cites W2106604059 @default.
- W4384829768 cites W2107003632 @default.
- W4384829768 cites W2111219435 @default.
- W4384829768 cites W2115834887 @default.
- W4384829768 cites W2122212319 @default.
- W4384829768 cites W2124528220 @default.
- W4384829768 cites W2126464081 @default.
- W4384829768 cites W2128208634 @default.
- W4384829768 cites W2135945048 @default.
- W4384829768 cites W2136253750 @default.
- W4384829768 cites W2136706405 @default.
- W4384829768 cites W2137440438 @default.
- W4384829768 cites W2137833823 @default.
- W4384829768 cites W2137906256 @default.
- W4384829768 cites W2138355969 @default.
- W4384829768 cites W2140489687 @default.
- W4384829768 cites W2143627435 @default.
- W4384829768 cites W2145254159 @default.
- W4384829768 cites W2146743102 @default.
- W4384829768 cites W2152173609 @default.