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• W4384831197 abstract "To evaluate presenting features and visual outcomes in eyes with acute syphilitic posterior placoid chorioretinopathy (ASPPC). Retrospective cohort study 24 eyes of 17 adult patients with ASPPC Chart review of patients with ASPPC who presented to the University of Michigan W. K. Kellogg Eye Center between January 1, 2012 and November 4, 2022. Demographic and clinical information, fundus photos, fundus autofluorescence, and spectral domain optical coherence tomography (SD-OCT) findings were reviewed. Clinical characteristics and visual acuity on presentation and follow-up examination. Median age was 46 [IQR: 38, 51]. At presentation, 20 (83.3%) eyes had subjectively decreased vision with median initial visual acuity (VA) of 0.54 [IQR: 0.35, 1.00] logarithm of the minimum angle of resolution (logMAR); at 45 days, median logMAR VA was 0.096 [IQR: 0.02, 0.17]. Initial VA was positively associated with posterior pole sparing lesions (coefficient estimate (CE): -0.75 (95% CI:-1.38, -0.12); p=0.030), and negatively associated with ellipsoid zone (EZ) disruption (CE: 0.72 (0.03, 1.42); p=0.044), subfoveal EZ disruption (CE: 0.62 (0.02, 1.23); p=0.046), and initial hyperreflective foci on SD-OCT (CE: 0.66 (0.09, 1.23); p=0.030). Female eyes were more likely and eyes with optic nerve abnormality were less likely to achieve a VA ≥20/40 (logMAR 0.30) (HR=3.36, (1.07, 10.6); p=0.038 and HR=0.34, (0.12, 0.96); p=0.042, respectively). This study of patients with ASPPC showed that symptomatic eyes had an improvement from a median VA of 20/69 on presentation to a median VA of 20/25 at 45 days. Female sex and absence of optic nerve involvement were associated with higher probability of achieving ≥20/40. These findings provide refined guidance for counseling patients who present with decreased vision due to ASPPC." @default.
• W4384831197 created "2023-07-21" @default.
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• W4384831197 date "2023-07-01" @default.
• W4384831197 modified "2023-10-15" @default.
• W4384831197 title "Clinical Characteristics and Visual Outcomes of Acute Syphilitic Posterior Placoid Chorioretinopathy" @default.
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• W4384831197 doi "https://doi.org/10.1016/j.oret.2023.07.014" @default.
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