FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384925239> ?p ?o ?g. }

• W4384925239 abstract "Approximately 20% of locally advanced rectal cancer (LARC) patients treated preoperatively with chemoradiotherapy (CRT) achieve pathologically confirmed complete regression. However, there are no clinically implemented biomarkers measurable in biopsies that are predictive of tumor regression. Here, we conducted multiplexed immunophenotyping of rectal cancer diagnostic biopsies from 16 LARC patients treated preoperatively with CRT. We identified that patients with greater tumor regression had higher tumor infiltration of pan-T cells and IRF8+HLA-DR+ cells prior to CRT. High IRF8+HLA-DR+ cell density was further associated with prolonged disease-specific survival with 83% survival at 5 y compared to 28% in patients with low infiltration. Contrastingly, low CD11c+ myeloid cell infiltration prior to CRT was a putative biomarker associated with longer 3- and 5-y disease-free survival. The results demonstrate the potential use of rectal cancer diagnostic biopsies to measure IRF8+ HLA-DR+ cells as predictors of CRT-induced tumor regression and CD11c+ myeloid cells as predictors of LARC patient survival." @default.
• W4384925239 created "2023-07-22" @default.
• W4384925239 creator A5017684393 @default.
• W4384925239 creator A5019013959 @default.
• W4384925239 creator A5039658289 @default.
• W4384925239 creator A5068308552 @default.
• W4384925239 creator A5069735960 @default.
• W4384925239 creator A5074842604 @default.
• W4384925239 creator A5082288933 @default.
• W4384925239 creator A5085372050 @default.
• W4384925239 creator A5087953446 @default.
• W4384925239 creator A5088299044 @default.
• W4384925239 date "2023-07-20" @default.
• W4384925239 modified "2023-10-07" @default.
• W4384925239 title "CD11c⁺ and IRF8⁺ cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy" @default.
• W4384925239 cites W1966107523 @default.
• W4384925239 cites W1979423888 @default.
• W4384925239 cites W2096817220 @default.
• W4384925239 cites W2129728624 @default.
• W4384925239 cites W2142507662 @default.
• W4384925239 cites W2161691060 @default.
• W4384925239 cites W2172170289 @default.
• W4384925239 cites W2191915025 @default.
• W4384925239 cites W2417625425 @default.
• W4384925239 cites W2585882251 @default.
• W4384925239 cites W2611557360 @default.
• W4384925239 cites W2738905412 @default.
• W4384925239 cites W2916620496 @default.
• W4384925239 cites W2927126716 @default.
• W4384925239 cites W2946089174 @default.
• W4384925239 cites W2949385284 @default.
• W4384925239 cites W2970536272 @default.
• W4384925239 cites W3043778187 @default.
• W4384925239 cites W3048268305 @default.
• W4384925239 cites W3049440636 @default.
• W4384925239 cites W3100153227 @default.
• W4384925239 cites W3128245531 @default.
• W4384925239 cites W3128646645 @default.
• W4384925239 cites W3139129133 @default.
• W4384925239 cites W3153491120 @default.
• W4384925239 cites W3206834054 @default.
• W4384925239 cites W4205454646 @default.
• W4384925239 cites W4210591755 @default.
• W4384925239 cites W4226144885 @default.
• W4384925239 cites W4291903684 @default.
• W4384925239 doi "https://doi.org/10.1080/2162402x.2023.2238506" @default.
• W4384925239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37485033" @default.
• W4384925239 hasPublicationYear "2023" @default.
• W4384925239 type Work @default.
• W4384925239 citedByCount "0" @default.
• W4384925239 crossrefType "journal-article" @default.
• W4384925239 hasAuthorship W4384925239A5017684393 @default.
• W4384925239 hasAuthorship W4384925239A5019013959 @default.
• W4384925239 hasAuthorship W4384925239A5039658289 @default.
• W4384925239 hasAuthorship W4384925239A5068308552 @default.
• W4384925239 hasAuthorship W4384925239A5069735960 @default.
• W4384925239 hasAuthorship W4384925239A5074842604 @default.
• W4384925239 hasAuthorship W4384925239A5082288933 @default.
• W4384925239 hasAuthorship W4384925239A5085372050 @default.
• W4384925239 hasAuthorship W4384925239A5087953446 @default.
• W4384925239 hasAuthorship W4384925239A5088299044 @default.
• W4384925239 hasBestOaLocation W43849252391 @default.
• W4384925239 hasConcept C121608353 @default.
• W4384925239 hasConcept C126322002 @default.
• W4384925239 hasConcept C127413603 @default.
• W4384925239 hasConcept C143998085 @default.
• W4384925239 hasConcept C147176958 @default.
• W4384925239 hasConcept C2777286243 @default.
• W4384925239 hasConcept C2778292576 @default.
• W4384925239 hasConcept C2778424827 @default.
• W4384925239 hasConcept C509974204 @default.
• W4384925239 hasConcept C526805850 @default.
• W4384925239 hasConcept C530470458 @default.
• W4384925239 hasConcept C71924100 @default.
• W4384925239 hasConceptScore W4384925239C121608353 @default.
• W4384925239 hasConceptScore W4384925239C126322002 @default.
• W4384925239 hasConceptScore W4384925239C127413603 @default.
• W4384925239 hasConceptScore W4384925239C143998085 @default.
• W4384925239 hasConceptScore W4384925239C147176958 @default.
• W4384925239 hasConceptScore W4384925239C2777286243 @default.
• W4384925239 hasConceptScore W4384925239C2778292576 @default.
• W4384925239 hasConceptScore W4384925239C2778424827 @default.
• W4384925239 hasConceptScore W4384925239C509974204 @default.
• W4384925239 hasConceptScore W4384925239C526805850 @default.
• W4384925239 hasConceptScore W4384925239C530470458 @default.
• W4384925239 hasConceptScore W4384925239C71924100 @default.
• W4384925239 hasIssue "1" @default.
• W4384925239 hasLocation W43849252391 @default.
• W4384925239 hasLocation W43849252392 @default.
• W4384925239 hasLocation W43849252393 @default.
• W4384925239 hasOpenAccess W4384925239 @default.
• W4384925239 hasPrimaryLocation W43849252391 @default.
• W4384925239 hasRelatedWork W1971164957 @default.
• W4384925239 hasRelatedWork W2129607807 @default.
• W4384925239 hasRelatedWork W2158347249 @default.
• W4384925239 hasRelatedWork W2249625608 @default.
• W4384925239 hasRelatedWork W2362524478 @default.
• W4384925239 hasRelatedWork W2404042595 @default.
• W4384925239 hasRelatedWork W2474665074 @default.
• W4384925239 hasRelatedWork W3090963952 @default.

• next