Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384925249> ?p ?o ?g. }
- W4384925249 endingPage "10745" @default.
- W4384925249 startingPage "10734" @default.
- W4384925249 abstract "Eukaryotic translation initiation factor 4E (eIF4E) is an RNA-binding protein that binds to the m7GpppX-cap at the 5′ terminus of coding mRNAs to initiate cap-dependent translation. While all cells require cap-dependent translation, cancer cells become addicted to enhanced translational capacity, driving the production of oncogenic proteins involved in proliferation, evasion of apoptosis, metastasis, and angiogenesis, among other cancerous phenotypes. eIF4E is the rate-limiting translation factor, and its activation has been shown to drive cancer initiation, progression, metastasis, and drug resistance. These findings have established eIF4E as a translational oncogene and promising, albeit challenging, anti-cancer therapeutic target. Although significant effort has been put forth toward inhibiting eIF4E, the design of cell-permeable, cap-competitive inhibitors remains a challenge. Herein, we describe our work toward solving this long-standing challenge. By employing an acyclic nucleoside phosphonate prodrug strategy, we report the synthesis of cell-permeable inhibitors of eIF4E binding to capped mRNA to inhibit cap-dependent translation." @default.
- W4384925249 created "2023-07-22" @default.
- W4384925249 creator A5000957789 @default.
- W4384925249 creator A5011241629 @default.
- W4384925249 creator A5024364780 @default.
- W4384925249 creator A5027601671 @default.
- W4384925249 creator A5027756423 @default.
- W4384925249 creator A5087615453 @default.
- W4384925249 date "2023-07-20" @default.
- W4384925249 modified "2023-10-14" @default.
- W4384925249 title "Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer" @default.
- W4384925249 cites W1608233475 @default.
- W4384925249 cites W1968919723 @default.
- W4384925249 cites W1988512225 @default.
- W4384925249 cites W1993251792 @default.
- W4384925249 cites W1994713811 @default.
- W4384925249 cites W1998755101 @default.
- W4384925249 cites W1999776725 @default.
- W4384925249 cites W2000083176 @default.
- W4384925249 cites W2001369160 @default.
- W4384925249 cites W2001443196 @default.
- W4384925249 cites W2005176113 @default.
- W4384925249 cites W2011961482 @default.
- W4384925249 cites W2027453759 @default.
- W4384925249 cites W2029396826 @default.
- W4384925249 cites W2037326045 @default.
- W4384925249 cites W2040885133 @default.
- W4384925249 cites W2062660352 @default.
- W4384925249 cites W2065251402 @default.
- W4384925249 cites W2067378334 @default.
- W4384925249 cites W2082834726 @default.
- W4384925249 cites W2134896734 @default.
- W4384925249 cites W2136345410 @default.
- W4384925249 cites W2136724758 @default.
- W4384925249 cites W2144081223 @default.
- W4384925249 cites W2154714625 @default.
- W4384925249 cites W2163341755 @default.
- W4384925249 cites W2165575537 @default.
- W4384925249 cites W2165806251 @default.
- W4384925249 cites W2307170928 @default.
- W4384925249 cites W2512985714 @default.
- W4384925249 cites W2752555298 @default.
- W4384925249 cites W2796947392 @default.
- W4384925249 cites W2811111314 @default.
- W4384925249 cites W2913322889 @default.
- W4384925249 cites W2942721876 @default.
- W4384925249 cites W2952082796 @default.
- W4384925249 cites W2971269891 @default.
- W4384925249 cites W3019978528 @default.
- W4384925249 cites W3120534848 @default.
- W4384925249 cites W3121029880 @default.
- W4384925249 cites W3188249441 @default.
- W4384925249 cites W3196329163 @default.
- W4384925249 cites W3207791129 @default.
- W4384925249 cites W4362596569 @default.
- W4384925249 doi "https://doi.org/10.1021/acs.jmedchem.3c00917" @default.
- W4384925249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37471629" @default.
- W4384925249 hasPublicationYear "2023" @default.
- W4384925249 type Work @default.
- W4384925249 citedByCount "1" @default.
- W4384925249 crossrefType "journal-article" @default.
- W4384925249 hasAuthorship W4384925249A5000957789 @default.
- W4384925249 hasAuthorship W4384925249A5011241629 @default.
- W4384925249 hasAuthorship W4384925249A5024364780 @default.
- W4384925249 hasAuthorship W4384925249A5027601671 @default.
- W4384925249 hasAuthorship W4384925249A5027756423 @default.
- W4384925249 hasAuthorship W4384925249A5087615453 @default.
- W4384925249 hasBestOaLocation W43849252492 @default.
- W4384925249 hasConcept C104317684 @default.
- W4384925249 hasConcept C105580179 @default.
- W4384925249 hasConcept C121608353 @default.
- W4384925249 hasConcept C142587794 @default.
- W4384925249 hasConcept C149364088 @default.
- W4384925249 hasConcept C161295673 @default.
- W4384925249 hasConcept C185592680 @default.
- W4384925249 hasConcept C2776054693 @default.
- W4384925249 hasConcept C2780394083 @default.
- W4384925249 hasConcept C33277056 @default.
- W4384925249 hasConcept C3675279 @default.
- W4384925249 hasConcept C4718897 @default.
- W4384925249 hasConcept C502942594 @default.
- W4384925249 hasConcept C5122226 @default.
- W4384925249 hasConcept C54355233 @default.
- W4384925249 hasConcept C55493867 @default.
- W4384925249 hasConcept C62493599 @default.
- W4384925249 hasConcept C86803240 @default.
- W4384925249 hasConcept C95444343 @default.
- W4384925249 hasConcept C96232424 @default.
- W4384925249 hasConcept C97154109 @default.
- W4384925249 hasConceptScore W4384925249C104317684 @default.
- W4384925249 hasConceptScore W4384925249C105580179 @default.
- W4384925249 hasConceptScore W4384925249C121608353 @default.
- W4384925249 hasConceptScore W4384925249C142587794 @default.
- W4384925249 hasConceptScore W4384925249C149364088 @default.
- W4384925249 hasConceptScore W4384925249C161295673 @default.
- W4384925249 hasConceptScore W4384925249C185592680 @default.
- W4384925249 hasConceptScore W4384925249C2776054693 @default.
- W4384925249 hasConceptScore W4384925249C2780394083 @default.