Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384926988> ?p ?o ?g. }
- W4384926988 endingPage "2767.e10" @default.
- W4384926988 startingPage "2753" @default.
- W4384926988 abstract "Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation by unknown ligand-dependent ubiquitin ligase machinery. NR degradation is critical for therapeutic efficacy in malignancies that are driven by retinoic acid and estrogen receptors. Here, we demonstrate the ubiquitin ligase UBR5 drives degradation of multiple agonist-bound NRs, including the retinoic acid receptor alpha (RARA), retinoid x receptor alpha (RXRA), glucocorticoid, estrogen, liver-X, progesterone, and vitamin D receptors. We present the high-resolution cryo-EMstructure of full-length human UBR5 and a negative stain model representing its interaction with RARA/RXRA. Agonist ligands induce sequential, mutually exclusive recruitment of nuclear coactivators (NCOAs) and UBR5 to chromatin to regulate transcriptional networks. Other pharmacological ligands such as selective estrogen receptor degraders (SERDs) degrade their receptors through differential recruitment of UBR5 or RNF111. We establish the UBR5 transcriptional regulatory hub as a common mediator and regulator of NR-induced transcription." @default.
- W4384926988 created "2023-07-22" @default.
- W4384926988 creator A5004273266 @default.
- W4384926988 creator A5006261099 @default.
- W4384926988 creator A5010019989 @default.
- W4384926988 creator A5010207791 @default.
- W4384926988 creator A5011922655 @default.
- W4384926988 creator A5012956545 @default.
- W4384926988 creator A5017218287 @default.
- W4384926988 creator A5027997415 @default.
- W4384926988 creator A5036196453 @default.
- W4384926988 creator A5036756728 @default.
- W4384926988 creator A5040096832 @default.
- W4384926988 creator A5040755339 @default.
- W4384926988 creator A5043375277 @default.
- W4384926988 creator A5044313264 @default.
- W4384926988 creator A5046286291 @default.
- W4384926988 creator A5046839261 @default.
- W4384926988 creator A5046846622 @default.
- W4384926988 creator A5047808577 @default.
- W4384926988 creator A5048546093 @default.
- W4384926988 creator A5052992360 @default.
- W4384926988 creator A5053196203 @default.
- W4384926988 creator A5054612687 @default.
- W4384926988 creator A5055307230 @default.
- W4384926988 creator A5059064293 @default.
- W4384926988 creator A5059957388 @default.
- W4384926988 creator A5065842591 @default.
- W4384926988 creator A5070668676 @default.
- W4384926988 creator A5072386024 @default.
- W4384926988 creator A5079209072 @default.
- W4384926988 creator A5081017494 @default.
- W4384926988 creator A5086733866 @default.
- W4384926988 creator A5086899217 @default.
- W4384926988 creator A5088181839 @default.
- W4384926988 creator A5089241905 @default.
- W4384926988 creator A5090425082 @default.
- W4384926988 date "2023-08-01" @default.
- W4384926988 modified "2023-10-17" @default.
- W4384926988 title "UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability" @default.
- W4384926988 cites W1561255797 @default.
- W4384926988 cites W1709815505 @default.
- W4384926988 cites W1838872057 @default.
- W4384926988 cites W1909732837 @default.
- W4384926988 cites W1934704664 @default.
- W4384926988 cites W1945772050 @default.
- W4384926988 cites W1972300087 @default.
- W4384926988 cites W1984573021 @default.
- W4384926988 cites W1989331231 @default.
- W4384926988 cites W1999574084 @default.
- W4384926988 cites W2001209104 @default.
- W4384926988 cites W2017797248 @default.
- W4384926988 cites W2019311111 @default.
- W4384926988 cites W2022977599 @default.
- W4384926988 cites W2036940526 @default.
- W4384926988 cites W2037607907 @default.
- W4384926988 cites W2040762618 @default.
- W4384926988 cites W2042636542 @default.
- W4384926988 cites W2049359175 @default.
- W4384926988 cites W2049650897 @default.
- W4384926988 cites W2050018101 @default.
- W4384926988 cites W2052988569 @default.
- W4384926988 cites W2056155028 @default.
- W4384926988 cites W2060862416 @default.
- W4384926988 cites W2064544547 @default.
- W4384926988 cites W2067233094 @default.
- W4384926988 cites W2082151361 @default.
- W4384926988 cites W2092196749 @default.
- W4384926988 cites W2092714565 @default.
- W4384926988 cites W2093146349 @default.
- W4384926988 cites W2104234755 @default.
- W4384926988 cites W2107018762 @default.
- W4384926988 cites W2108234281 @default.
- W4384926988 cites W2111504523 @default.
- W4384926988 cites W2112823160 @default.
- W4384926988 cites W2113811443 @default.
- W4384926988 cites W2115778133 @default.
- W4384926988 cites W2124026197 @default.
- W4384926988 cites W2124097252 @default.
- W4384926988 cites W2141478391 @default.
- W4384926988 cites W2143103923 @default.
- W4384926988 cites W2144378498 @default.
- W4384926988 cites W2146512944 @default.
- W4384926988 cites W2149044745 @default.
- W4384926988 cites W2151286904 @default.
- W4384926988 cites W2152239989 @default.
- W4384926988 cites W2154719037 @default.
- W4384926988 cites W2160380797 @default.
- W4384926988 cites W2161977828 @default.
- W4384926988 cites W2164508407 @default.
- W4384926988 cites W2168909179 @default.
- W4384926988 cites W2169456326 @default.
- W4384926988 cites W2170325085 @default.
- W4384926988 cites W2170830174 @default.
- W4384926988 cites W2171808845 @default.
- W4384926988 cites W2179438025 @default.
- W4384926988 cites W2225259556 @default.
- W4384926988 cites W2342500021 @default.