Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384927102> ?p ?o ?g. }
- W4384927102 endingPage "109585" @default.
- W4384927102 startingPage "109585" @default.
- W4384927102 abstract "Traumatic brain injury (TBI) caused by acoustic blast overpressure (ABO) is frequently associated with chronic visual deficits in military personnel and civilians. In this study, we characterized retinal gliotic response in adult male rats following a single ABO exposure directed to one side of the head. Expression of gliosis markers and intermediate filaments was assessed at 48 h and 1 wk post-ABO exposure, in comparison to age-matched non-exposed control retina. In response to a single ABO exposure, type III IF, glial fibrillary acidic protein (GFAP) was variably induced in a subpopulation of retinal Müller glia in ipsilateral eyes. ABO-exposed eyes exhibited radial Müller glial GFAP filament extension through the inner plexiform layer (IPL) and the inner nuclear layer (INL) through the retina in both the nasal quadrant and juxta-optic nerve head (jONH) eye regions at 1 wk post-ABO. We observed an ∼6-fold increase (p ≤ 0.05) in radial glial GFAP immunolabeling in the IPL in both eye regions, in comparison to regionally matched controls. Similarly, GFAP extension through the INL into the outer retina was elevated ∼3-fold, p ≤ 0.05 in the nasal retina, but exhibited wider variability in the jONH retina. In contrast, constitutive type III IF vimentin exhibited greater remodeling in retinal Müller glia through the jONH retina compared to the nasal retina in response to ABO. We observed areas of lateral vimentin remodeling through the Müller glial end-feet, and greater mid-outer retinal radial vimentin IF extension in a subpopulation of glia at 1 wk post-ABO. We also observed a significant increase in total retinal levels of the type III IF desmin in ABO-exposed retina vs. controls (∼1.6-fold, p ≤ 0.01). In addition, ABO-exposure elicited varied glial induction of developmentally regulated type VI family IFs (nestin and synemin) in subpopulations of Müller cells at 48 h and 1 wk post-ABO. We demonstrate that multiple glial phenotypes emerge in the rat retina following a single ABO exposure, rather than a global homogeneous retinal glial response, involving less well characterized IF protein forms which warrant further investigation in the context of ABO-induced retinal gliosis." @default.
- W4384927102 created "2023-07-22" @default.
- W4384927102 creator A5012234271 @default.
- W4384927102 creator A5015981220 @default.
- W4384927102 creator A5021917066 @default.
- W4384927102 creator A5022591492 @default.
- W4384927102 creator A5031519927 @default.
- W4384927102 creator A5039367843 @default.
- W4384927102 date "2023-09-01" @default.
- W4384927102 modified "2023-09-23" @default.
- W4384927102 title "Retinal gliosis and phenotypic diversity of intermediate filament induction and remodeling upon acoustic blast overpressure (ABO) exposure to the rat eye" @default.
- W4384927102 cites W1487222554 @default.
- W4384927102 cites W1507738818 @default.
- W4384927102 cites W1601380713 @default.
- W4384927102 cites W1602710240 @default.
- W4384927102 cites W1625720053 @default.
- W4384927102 cites W1957069581 @default.
- W4384927102 cites W1965114230 @default.
- W4384927102 cites W1967071229 @default.
- W4384927102 cites W1973044208 @default.
- W4384927102 cites W1979978460 @default.
- W4384927102 cites W1987294948 @default.
- W4384927102 cites W1989502888 @default.
- W4384927102 cites W1991991135 @default.
- W4384927102 cites W1994626566 @default.
- W4384927102 cites W2006167447 @default.
- W4384927102 cites W2007206378 @default.
- W4384927102 cites W2020851457 @default.
- W4384927102 cites W2022903299 @default.
- W4384927102 cites W2023290311 @default.
- W4384927102 cites W2024255561 @default.
- W4384927102 cites W2029399003 @default.
- W4384927102 cites W2030812875 @default.
- W4384927102 cites W2035471044 @default.
- W4384927102 cites W2058010126 @default.
- W4384927102 cites W2066640119 @default.
- W4384927102 cites W2067896405 @default.
- W4384927102 cites W2071696504 @default.
- W4384927102 cites W2072667331 @default.
- W4384927102 cites W2079473078 @default.
- W4384927102 cites W2083993537 @default.
- W4384927102 cites W2084353555 @default.
- W4384927102 cites W2087609160 @default.
- W4384927102 cites W2090437718 @default.
- W4384927102 cites W2092987485 @default.
- W4384927102 cites W2100559561 @default.
- W4384927102 cites W2102089332 @default.
- W4384927102 cites W2108656488 @default.
- W4384927102 cites W2110664545 @default.
- W4384927102 cites W2113588626 @default.
- W4384927102 cites W2117432287 @default.
- W4384927102 cites W2119624278 @default.
- W4384927102 cites W2122741140 @default.
- W4384927102 cites W2126902662 @default.
- W4384927102 cites W2132595805 @default.
- W4384927102 cites W2145791605 @default.
- W4384927102 cites W2150428516 @default.
- W4384927102 cites W2152415360 @default.
- W4384927102 cites W2157059052 @default.
- W4384927102 cites W2167279371 @default.
- W4384927102 cites W2170592501 @default.
- W4384927102 cites W2173210998 @default.
- W4384927102 cites W2181835826 @default.
- W4384927102 cites W2189535841 @default.
- W4384927102 cites W2270572800 @default.
- W4384927102 cites W2331001657 @default.
- W4384927102 cites W2406832004 @default.
- W4384927102 cites W2548027654 @default.
- W4384927102 cites W2587874057 @default.
- W4384927102 cites W2606228359 @default.
- W4384927102 cites W2622111186 @default.
- W4384927102 cites W2755452354 @default.
- W4384927102 cites W2794763796 @default.
- W4384927102 cites W2885199266 @default.
- W4384927102 cites W2889478730 @default.
- W4384927102 cites W2893271207 @default.
- W4384927102 cites W2954514759 @default.
- W4384927102 cites W2958314917 @default.
- W4384927102 cites W2966797996 @default.
- W4384927102 cites W2979820907 @default.
- W4384927102 cites W2993468802 @default.
- W4384927102 cites W3013177651 @default.
- W4384927102 cites W3019974802 @default.
- W4384927102 cites W3033863507 @default.
- W4384927102 cites W30341297 @default.
- W4384927102 cites W3038340620 @default.
- W4384927102 cites W3107194769 @default.
- W4384927102 cites W3120152290 @default.
- W4384927102 cites W3152389647 @default.
- W4384927102 cites W3183251333 @default.
- W4384927102 cites W3191096557 @default.
- W4384927102 cites W3191350387 @default.
- W4384927102 cites W3212382376 @default.
- W4384927102 cites W4232005894 @default.
- W4384927102 cites W4282946388 @default.
- W4384927102 cites W4312187891 @default.
- W4384927102 cites W757278435 @default.
- W4384927102 doi "https://doi.org/10.1016/j.exer.2023.109585" @default.