FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384927252> ?p ?o ?g. }

• W4384927252 abstract "Abstract Exposure to stressful stimuli promotes multi-system biological responses to restore homeostasis. Catecholaminergic neurons in the rostral ventrolateral medulla (RVLM) facilitate sympathetic activity and promote physiological adaptations, including glycemic mobilization and corticosterone release. While it is unclear how brain regions involved in the cognitive appraisal of stress regulate RVLM neural activity, recent studies found that the rodent ventromedial prefrontal cortex (vmPFC) mediates stress appraisal and physiological stress responses. Thus, a vmPFC-RVLM connection could represent a circuit mechanism linking stress appraisal and physiological reactivity. The current study investigated a direct vmPFC-RVLM circuit utilizing genetically-encoded anterograde and retrograde tract tracers. Together, these studies found that stress-reactive vmPFC neurons project to catecholaminergic neurons throughout the ventrolateral medulla in male and female rats. Next, we utilized optogenetic terminal stimulation to evoke vmPFC synaptic glutamate release in the RVLM. Photostimulating the vmPFC-RVLM circuit during restraint stress suppressed glycemic stress responses in males, without altering the female response. However, circuit stimulation decreased corticosterone responses to stress in both sexes. Circuit stimulation did not modulate affective behavior in either sex. Further analysis indicated that circuit stimulation preferentially activated non-catecholaminergic medullary neurons in both sexes. Additionally, vmPFC terminals targeted medullary inhibitory neurons. Thus, both male and female rats have a direct vmPFC projection to the RVLM that reduces endocrine stress responses, likely through the recruitment of local RVLM inhibitory neurons. Ultimately, the excitatory/inhibitory balance of vmPFC synapses in the RVLM may regulate stress reactivity as well as stress-related health outcomes. First author profile Sebastian Pace is a Ph.D. candidate in the laboratory of Brent Myers at Colorado State University. Before beginning his Ph.D., Sebastian completed his B.S. and M.S. at the University of Texas-El Paso. While completing his M.S. he worked in the Karine Fénelon Lab. Sebastian’s current research project focuses on understanding how corticolimbic inputs to the medullary brainstem regulate sympathetic and neuroendocrine stress responses. Key points summary Glutamatergic efferents from the ventromedial prefrontal cortex target catecholaminergic neurons throughout the ventrolateral medulla. Partially segregated, stress-responsive ventromedial prefrontal cortex populations innervate the rostral and caudal ventrolateral medulla. Stimulating ventromedial prefrontal cortex synapses in the rostral ventrolateral medulla decreases stress-induced glucocorticoid release in males and females. Stimulating ventromedial prefrontal cortex terminals in the rostral ventrolateral medulla preferentially activates non-catecholaminergic neurons. Ventromedial prefrontal cortex terminals target medullary inhibitory neurons. Graphical Abstract" @default.
• W4384927252 created "2023-07-22" @default.
• W4384927252 creator A5025061102 @default.
• W4384927252 creator A5034732866 @default.
• W4384927252 creator A5041802535 @default.
• W4384927252 creator A5072201670 @default.
• W4384927252 creator A5080821424 @default.
• W4384927252 date "2023-07-20" @default.
• W4384927252 modified "2023-09-25" @default.
• W4384927252 title "Cortical-brainstem circuitry attenuates physiological stress reactivity" @default.
• W4384927252 cites W1812482953 @default.
• W4384927252 cites W1965965542 @default.
• W4384927252 cites W1966409424 @default.
• W4384927252 cites W1971484280 @default.
• W4384927252 cites W1986320798 @default.
• W4384927252 cites W1986429531 @default.
• W4384927252 cites W1991236735 @default.
• W4384927252 cites W1995322135 @default.
• W4384927252 cites W2012483271 @default.
• W4384927252 cites W2017795589 @default.
• W4384927252 cites W2029704174 @default.
• W4384927252 cites W2032344007 @default.
• W4384927252 cites W2035942099 @default.
• W4384927252 cites W2040527392 @default.
• W4384927252 cites W2040898679 @default.
• W4384927252 cites W2042759694 @default.
• W4384927252 cites W2044710410 @default.
• W4384927252 cites W2046960533 @default.
• W4384927252 cites W2052963130 @default.
• W4384927252 cites W2053472601 @default.
• W4384927252 cites W2073292853 @default.
• W4384927252 cites W2080779628 @default.
• W4384927252 cites W2081534285 @default.
• W4384927252 cites W2091558007 @default.
• W4384927252 cites W2092831348 @default.
• W4384927252 cites W2096022216 @default.
• W4384927252 cites W2098159477 @default.
• W4384927252 cites W2100762371 @default.
• W4384927252 cites W2119084915 @default.
• W4384927252 cites W2129620746 @default.
• W4384927252 cites W2133371501 @default.
• W4384927252 cites W2135768681 @default.
• W4384927252 cites W2135955567 @default.
• W4384927252 cites W2157041879 @default.
• W4384927252 cites W2159202946 @default.
• W4384927252 cites W2178943156 @default.
• W4384927252 cites W2197425890 @default.
• W4384927252 cites W2235848473 @default.
• W4384927252 cites W2247459508 @default.
• W4384927252 cites W249845531 @default.
• W4384927252 cites W2556344411 @default.
• W4384927252 cites W2624833241 @default.
• W4384927252 cites W2737321270 @default.
• W4384927252 cites W2765776499 @default.
• W4384927252 cites W2766340254 @default.
• W4384927252 cites W2801385314 @default.
• W4384927252 cites W2893084251 @default.
• W4384927252 cites W2896010431 @default.
• W4384927252 cites W2897363581 @default.
• W4384927252 cites W2948893112 @default.
• W4384927252 cites W2948950245 @default.
• W4384927252 cites W2995812024 @default.
• W4384927252 cites W3045970602 @default.
• W4384927252 cites W3108513301 @default.
• W4384927252 cites W3134463711 @default.
• W4384927252 cites W3156390271 @default.
• W4384927252 cites W3200413015 @default.
• W4384927252 cites W4200257942 @default.
• W4384927252 cites W4321367730 @default.
• W4384927252 cites W4363645824 @default.
• W4384927252 doi "https://doi.org/10.1101/2023.07.19.549781" @default.
• W4384927252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37502866" @default.
• W4384927252 hasPublicationYear "2023" @default.
• W4384927252 type Work @default.
• W4384927252 citedByCount "0" @default.
• W4384927252 crossrefType "posted-content" @default.
• W4384927252 hasAuthorship W4384927252A5025061102 @default.
• W4384927252 hasAuthorship W4384927252A5034732866 @default.
• W4384927252 hasAuthorship W4384927252A5041802535 @default.
• W4384927252 hasAuthorship W4384927252A5072201670 @default.
• W4384927252 hasAuthorship W4384927252A5080821424 @default.
• W4384927252 hasBestOaLocation W43849272521 @default.
• W4384927252 hasConcept C112592302 @default.
• W4384927252 hasConcept C126322002 @default.
• W4384927252 hasConcept C134018914 @default.
• W4384927252 hasConcept C15490471 @default.
• W4384927252 hasConcept C15744967 @default.
• W4384927252 hasConcept C169760540 @default.
• W4384927252 hasConcept C170493617 @default.
• W4384927252 hasConcept C17077164 @default.
• W4384927252 hasConcept C24998067 @default.
• W4384927252 hasConcept C2776824294 @default.
• W4384927252 hasConcept C2777659854 @default.
• W4384927252 hasConcept C2778110749 @default.
• W4384927252 hasConcept C2779245659 @default.
• W4384927252 hasConcept C2780352252 @default.
• W4384927252 hasConcept C33114225 @default.
• W4384927252 hasConcept C43601244 @default.
• W4384927252 hasConcept C513476851 @default.
• W4384927252 hasConcept C529278444 @default.

• next