Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384927580> ?p ?o ?g. }
- W4384927580 endingPage "1322" @default.
- W4384927580 startingPage "1310" @default.
- W4384927580 abstract "The histidine triad nucleotide binding protein 1 (HINT1) is a nucleoside phosphoramidase that has garnered interest due to its widespread expression and participation in a broad range of biological processes. Herein, we discuss the role of HINT1 as a regulator of several CNS functions, tumor suppressor, and mast cell activator via its interactions with multiple G-protein-coupled receptors and transcription factors. Importantly, altered HINT1 expression and mutation are connected to the progression of multiple disease states, including several neuropsychiatric disorders, peripheral neuropathy, and tumorigenesis. Additionally, due to its involvement in the activation of several clinically used phosphoramidate prodrugs, tremendous efforts have been made to better understand the interactions behind nucleoside binding and phosphoramidate hydrolysis by HINT1. We detail the substrate specificity and catalytic mechanism of HINT1 hydrolysis, while highlighting the structural biology behind these efforts. The aim of this review is to summarize the multitude of biological and pharmacological functions in which HINT1 participates while addressing the areas of need for future research." @default.
- W4384927580 created "2023-07-22" @default.
- W4384927580 creator A5038114180 @default.
- W4384927580 creator A5049419285 @default.
- W4384927580 creator A5055669445 @default.
- W4384927580 date "2023-07-20" @default.
- W4384927580 modified "2023-10-15" @default.
- W4384927580 title "The Many Faces of Histidine Triad Nucleotide Binding Protein 1 (HINT1)" @default.
- W4384927580 cites W1470180351 @default.
- W4384927580 cites W149530718 @default.
- W4384927580 cites W1508093688 @default.
- W4384927580 cites W1527450555 @default.
- W4384927580 cites W1599102428 @default.
- W4384927580 cites W1970263257 @default.
- W4384927580 cites W1972601687 @default.
- W4384927580 cites W1973730962 @default.
- W4384927580 cites W1975912240 @default.
- W4384927580 cites W1978208403 @default.
- W4384927580 cites W1982351569 @default.
- W4384927580 cites W1982874357 @default.
- W4384927580 cites W1984201743 @default.
- W4384927580 cites W1985065073 @default.
- W4384927580 cites W1987780990 @default.
- W4384927580 cites W1987935503 @default.
- W4384927580 cites W1995396220 @default.
- W4384927580 cites W1996451919 @default.
- W4384927580 cites W1998139425 @default.
- W4384927580 cites W1999776725 @default.
- W4384927580 cites W2000371206 @default.
- W4384927580 cites W2000378697 @default.
- W4384927580 cites W2005642753 @default.
- W4384927580 cites W2006928905 @default.
- W4384927580 cites W2010346442 @default.
- W4384927580 cites W2010452680 @default.
- W4384927580 cites W2011968242 @default.
- W4384927580 cites W2015141538 @default.
- W4384927580 cites W2016984588 @default.
- W4384927580 cites W2019381923 @default.
- W4384927580 cites W2020283319 @default.
- W4384927580 cites W2020361084 @default.
- W4384927580 cites W2021789466 @default.
- W4384927580 cites W2022083096 @default.
- W4384927580 cites W2023180769 @default.
- W4384927580 cites W2025449560 @default.
- W4384927580 cites W2027568564 @default.
- W4384927580 cites W2028243845 @default.
- W4384927580 cites W2028615037 @default.
- W4384927580 cites W2032853101 @default.
- W4384927580 cites W2034291149 @default.
- W4384927580 cites W2036426257 @default.
- W4384927580 cites W2043022768 @default.
- W4384927580 cites W2043992563 @default.
- W4384927580 cites W2044791477 @default.
- W4384927580 cites W2045174016 @default.
- W4384927580 cites W2046152220 @default.
- W4384927580 cites W2046215765 @default.
- W4384927580 cites W2048756941 @default.
- W4384927580 cites W2054673335 @default.
- W4384927580 cites W2057259362 @default.
- W4384927580 cites W2057834641 @default.
- W4384927580 cites W2060234052 @default.
- W4384927580 cites W2063378067 @default.
- W4384927580 cites W2065665170 @default.
- W4384927580 cites W2073517737 @default.
- W4384927580 cites W2083354976 @default.
- W4384927580 cites W2084148515 @default.
- W4384927580 cites W2084641677 @default.
- W4384927580 cites W2092698305 @default.
- W4384927580 cites W2093541381 @default.
- W4384927580 cites W2095058079 @default.
- W4384927580 cites W2097418059 @default.
- W4384927580 cites W2114053353 @default.
- W4384927580 cites W2129510970 @default.
- W4384927580 cites W2129827813 @default.
- W4384927580 cites W2134436661 @default.
- W4384927580 cites W2142627450 @default.
- W4384927580 cites W2143442642 @default.
- W4384927580 cites W2159495147 @default.
- W4384927580 cites W2165611390 @default.
- W4384927580 cites W2166662718 @default.
- W4384927580 cites W2166695812 @default.
- W4384927580 cites W2199823879 @default.
- W4384927580 cites W2284332452 @default.
- W4384927580 cites W2334261208 @default.
- W4384927580 cites W2347163170 @default.
- W4384927580 cites W2410066853 @default.
- W4384927580 cites W2431050627 @default.
- W4384927580 cites W2434649470 @default.
- W4384927580 cites W2467939228 @default.
- W4384927580 cites W2520632143 @default.
- W4384927580 cites W2549858084 @default.
- W4384927580 cites W2691725800 @default.
- W4384927580 cites W2742581645 @default.
- W4384927580 cites W2763358936 @default.
- W4384927580 cites W2803075510 @default.
- W4384927580 cites W2804143011 @default.
- W4384927580 cites W2804467769 @default.
- W4384927580 cites W2913856209 @default.